Advancements in DNAzyme-based biosensors for the detection of hazardous substances in foodstuff: current applications and future perspectives DOI

Taolin Li,

Yijia Zhang, Weiwei Cheng

et al.

Critical Reviews in Food Science and Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 20

Published: April 6, 2025

DNAzyme-based biosensors have emerged as a promising tool for ensuring food safety due to their high sensitivity, specificity, and potential rapid, cost-effective detection of hazardous substances. These leverage DNAzymes-catalytically active DNA molecules-to detect range contaminants, including metal ions, fungal toxins, pesticides, pathogens. While show significant advantages over conventional techniques, challenges such nuclease degradation, interference from complex sample matrices, the costs associated with DNAzyme synthesis still hinder widespread application. Recent advancements in stability DNAzymes, immobilization strategies, integration nanomaterials are progressively addressing these limitations, enhancing performance reliability sensors. This review highlights structural catalytic characteristics assesses current applications safety, discusses innovative strategies overcome existing challenges. The continuous evolution biosensors, particularly design device integration, holds great promise future role routine, reliable analysis.

Language: Английский

Nanozyme-based wearable biosensors for application in healthcare DOI Creative Commons
Yingcong Zhang, Yiran Yang,

Zhixin Yin

et al.

iScience, Journal Year: 2025, Volume and Issue: 28(2), P. 111763 - 111763

Published: Jan. 7, 2025

Recent years have witnessed tremendous advances in wearable sensors, which play an essential role personalized healthcare for their ability real-time sensing and detection of human health information. Nanozymes, capable mimicking the functions natural enzymes addressing limitations, possess unique advantages such as structural stability, low cost, ease mass production, making them particularly beneficial constructing recognition units biosensors. In this review, we aim to delineate latest advancements nanozymes development biosensors, focusing on key developments nanozyme immobilization strategies, technologies, biomedical applications. The review also highlights current challenges future perspectives. Ultimately, it aims provide insights research endeavors rapidly evolving area.

Language: Английский

Citations

3
Innovative Nanozyme-Based Detection Methods for Biomarkers in Interstitial Fluid DOI

Jiuhong Zhao,

Junjie Tian, Xiaoyu Zhang

et al.

TrAC Trends in Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 118248 - 118248

Published: April 1, 2025

Language: Английский

Citations

1
FeCuS multilayer nanoflowers loaded with N-CDs dual-mode method for the detection of uric acid and gout risk prediction with the aid of chemometrics DOI

Rou Cheng,

Chunyan Yan, Zhenggang Xiao

et al.

Talanta, Journal Year: 2025, Volume and Issue: 287, P. 127700 - 127700

Published: Feb. 5, 2025

Language: Английский

Citations

0
Advancements in DNAzyme-based biosensors for the detection of hazardous substances in foodstuff: current applications and future perspectives DOI

Taolin Li,

Yijia Zhang, Weiwei Cheng

et al.

Critical Reviews in Food Science and Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 20

Published: April 6, 2025

DNAzyme-based biosensors have emerged as a promising tool for ensuring food safety due to their high sensitivity, specificity, and potential rapid, cost-effective detection of hazardous substances. These leverage DNAzymes-catalytically active DNA molecules-to detect range contaminants, including metal ions, fungal toxins, pesticides, pathogens. While show significant advantages over conventional techniques, challenges such nuclease degradation, interference from complex sample matrices, the costs associated with DNAzyme synthesis still hinder widespread application. Recent advancements in stability DNAzymes, immobilization strategies, integration nanomaterials are progressively addressing these limitations, enhancing performance reliability sensors. This review highlights structural catalytic characteristics assesses current applications safety, discusses innovative strategies overcome existing challenges. The continuous evolution biosensors, particularly design device integration, holds great promise future role routine, reliable analysis.

Language: Английский

Citations

0