Dissolvable Core–Shell Microneedle Patch for Biphasic Drug Delivery To Enhance Diabetic Wound Healing DOI
Ying Xie,

Zhongdong Wu,

Junping Wang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

Diabetic wounds constitute one of the most prevalent complications among diabetic patients, characterized by a low healing rate and high recurrence rate. These frequently result in ulceration, amputation, and, severe cases, life-threatening conditions. The difficulty wound patients is primarily attributed to invasion pathogenic bacteria, dysregulation inflammatory response, insufficient angiogenesis. In this study, we developed core-shell microneedle (MN) patch that delivers antimicrobial agents, anti-inflammatory angiogenic agents biphasic release mode for treatment healing. Tetracycline hydrochloride (TCH) drug-carrying nanoparticles (SIM-PLGA NPs) were coated inner layer tip respond early bacterial infection subsequently induce Metformin (Met) was loaded onto outer shell needle regulate response. MN (TCH/SIM-PLGA NPs/Met MN) inhibited promoted cell migration application TCH/SIM-PLGA constructed model reduced inflammation, induced angiogenesis, encouraged collagen deposition tissue regeneration during repair, accelerated closure. This system, combined with MN, exhibits significant potential broader applications

Language: Английский

Dissolvable Core–Shell Microneedle Patch for Biphasic Drug Delivery To Enhance Diabetic Wound Healing DOI
Ying Xie,

Zhongdong Wu,

Junping Wang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

Diabetic wounds constitute one of the most prevalent complications among diabetic patients, characterized by a low healing rate and high recurrence rate. These frequently result in ulceration, amputation, and, severe cases, life-threatening conditions. The difficulty wound patients is primarily attributed to invasion pathogenic bacteria, dysregulation inflammatory response, insufficient angiogenesis. In this study, we developed core-shell microneedle (MN) patch that delivers antimicrobial agents, anti-inflammatory angiogenic agents biphasic release mode for treatment healing. Tetracycline hydrochloride (TCH) drug-carrying nanoparticles (SIM-PLGA NPs) were coated inner layer tip respond early bacterial infection subsequently induce Metformin (Met) was loaded onto outer shell needle regulate response. MN (TCH/SIM-PLGA NPs/Met MN) inhibited promoted cell migration application TCH/SIM-PLGA constructed model reduced inflammation, induced angiogenesis, encouraged collagen deposition tissue regeneration during repair, accelerated closure. This system, combined with MN, exhibits significant potential broader applications

Language: Английский

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