ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response

Molecular Cell, Journal Year: 2017, Volume and Issue: 66(6), P. 801 - 817

Published: June 1, 2017

Language: Английский

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Cdks, cyclins and CKIs: roles beyond cell cycle regulation

Development, Journal Year: 2013, Volume and Issue: 140(15), P. 3079 - 3093

Published: July 16, 2013

Cyclin-dependent kinases (Cdks) are serine/threonine and their catalytic activities modulated by interactions with cyclins Cdk inhibitors (CKIs). Close cooperation between this trio is necessary for ensuring orderly progression through the cell cycle. In addition to well-established function in cycle control, it becoming increasingly apparent that mammalian Cdks, CKIs play indispensable roles processes such as transcription, epigenetic regulation, metabolism, stem self-renewal, neuronal functions spermatogenesis. Even more remarkably, they can accomplish some of these tasks individually, without need Cdk/cyclin complex formation or kinase activity. Review, we discuss latest revelations about goal showcasing functional diversity beyond regulation impact on development disease mammals.

Language: Английский

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The essential kinase ATR: ensuring faithful duplication of a challenging genome

Nature Reviews Molecular Cell Biology, Journal Year: 2017, Volume and Issue: 18(10), P. 622 - 636

Published: Aug. 16, 2017

Language: Английский

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Mechanisms and function of substrate recruitment by F-box proteins

Nature Reviews Molecular Cell Biology, Journal Year: 2013, Volume and Issue: 14(6), P. 369 - 381

Published: May 9, 2013

Language: Английский

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Roles of F-box proteins in cancer

Nature reviews. Cancer, Journal Year: 2014, Volume and Issue: 14(4), P. 233 - 247

Published: March 24, 2014

Language: Английский

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Ribonucleotide reductase and cancer: biological mechanisms and targeted therapies

Oncogene, Journal Year: 2014, Volume and Issue: 34(16), P. 2011 - 2021

Published: June 9, 2014

Language: Английский

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Mechanisms of Oncogene-Induced Replication Stress: Jigsaw Falling into Place

Cancer Discovery, Journal Year: 2018, Volume and Issue: 8(5), P. 537 - 555

Published: April 13, 2018

Abstract Oncogene activation disturbs cellular processes and accommodates a complex landscape of changes in the genome that contribute to genomic instability, which accelerates mutation rates promotes tumorigenesis. Part this turmoil involves deregulation physiologic DNA replication, widely described as replication stress. Oncogene-induced stress is an early driver instability attributed plethora factors, most notably aberrant origin firing, replication–transcription collisions, reactive oxygen species, defective nucleotide metabolism. Significance: Replication fundamental step tumorigenesis has been associated with many activated oncogenes. Deciphering mechanisms response may provide new avenues for targeted cancer treatment. In review, we discuss latest findings on examine various through oncogenes induce Cancer Discov; 8(5); 537–55. ©2018 AACR.

Language: Английский

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Targeting ATR in cancer

Nature reviews. Cancer, Journal Year: 2018, Volume and Issue: 18(9), P. 586 - 595

Published: June 13, 2018

Language: Английский

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Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation

Cancer Cell, Journal Year: 2015, Volume and Issue: 28(5), P. 557 - 568

Published: Oct. 25, 2015

Language: Английский

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Distinct but Concerted Roles of ATR, DNA-PK, and Chk1 in Countering Replication Stress during S Phase

Molecular Cell, Journal Year: 2015, Volume and Issue: 59(6), P. 1011 - 1024

Published: Sept. 1, 2015

Language: Английский

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