The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications

Cellular and Molecular Immunology, Journal Year: 2020, Volume and Issue: 17(8), P. 807 - 821

Published: July 1, 2020

Abstract Immunotherapy has revolutionized cancer treatment and rejuvenated the field of tumor immunology. Several types immunotherapy, including adoptive cell transfer (ACT) immune checkpoint inhibitors (ICIs), have obtained durable clinical responses, but their efficacies vary, only subsets patients can benefit from them. Immune infiltrates in microenvironment (TME) been shown to play a key role development will affect outcomes patients. Comprehensive profiling tumor-infiltrating cells would shed light on mechanisms cancer–immune evasion, thus providing opportunities for novel therapeutic strategies. However, highly heterogeneous dynamic nature TME impedes precise dissection intratumoral cells. With recent advances single-cell technologies such as RNA sequencing (scRNA-seq) mass cytometry, systematic interrogation is feasible provide insights into functional diversities In this review, we outline progress particularly by focusing landmark studies characterization tumor-associated cells, summarize phenotypic connections with immunotherapy. We believe review could strengthen our understanding facilitate elucidation modulation progression, guide immunotherapies treatment.

Language: Английский

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Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment

Cell, Journal Year: 2018, Volume and Issue: 174(5), P. 1293 - 1308.e36

Published: June 28, 2018

Language: Английский

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Macrophages and Metabolism in the Tumor Microenvironment

Cell Metabolism, Journal Year: 2019, Volume and Issue: 30(1), P. 36 - 50

Published: July 1, 2019

Language: Английский

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Landscape and Dynamics of Single Immune Cells in Hepatocellular Carcinoma

Cell, Journal Year: 2019, Volume and Issue: 179(4), P. 829 - 845.e20

Published: Oct. 1, 2019

Language: Английский

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Organoid Modeling of the Tumor Immune Microenvironment

Cell, Journal Year: 2018, Volume and Issue: 175(7), P. 1972 - 1988.e16

Published: Dec. 1, 2018

Language: Английский

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Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates

Nature, Journal Year: 2018, Volume and Issue: 557(7706), P. 575 - 579

Published: May 1, 2018

Language: Английский

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Macrophages as tools and targets in cancer therapy

Nature Reviews Drug Discovery, Journal Year: 2022, Volume and Issue: 21(11), P. 799 - 820

Published: Aug. 16, 2022

Language: Английский

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CD8+ T cell states in human cancer: insights from single-cell analysis

Nature reviews. Cancer, Journal Year: 2020, Volume and Issue: 20(4), P. 218 - 232

Published: Feb. 5, 2020

Language: Английский

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Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade

Cell, Journal Year: 2017, Volume and Issue: 170(6), P. 1120 - 1133.e17

Published: Aug. 10, 2017

Language: Английский

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Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer

Cell, Journal Year: 2020, Volume and Issue: 181(2), P. 442 - 459.e29

Published: April 1, 2020

Language: Английский

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