Innate Lymphoid Cells: 10 Years On

Cell, Journal Year: 2018, Volume and Issue: 174(5), P. 1054 - 1066

Published: Aug. 1, 2018

Language: Английский

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IFNγ: signalling, epigenetics and roles in immunity, metabolism, disease and cancer immunotherapy

Nature reviews. Immunology, Journal Year: 2018, Volume and Issue: 18(9), P. 545 - 558

Published: June 19, 2018

Language: Английский

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Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

European Journal of Immunology, Journal Year: 2019, Volume and Issue: 49(10), P. 1457 - 1973

Published: Oct. 1, 2019

These guidelines are a consensus work of considerable number members the immunology and flow cytometry community. They provide theory key practical aspects enabling immunologists to avoid common errors that often undermine immunological data. Notably, there comprehensive sections all major immune cell types with helpful Tables detailing phenotypes in murine human cells. The latest techniques applications also described, featuring examples data can be generated and, importantly, how analysed. Furthermore, tips, tricks pitfalls avoid, written peer-reviewed by leading experts field, making this an essential research companion.

Language: Английский

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The Dual Nature of Type I and Type II Interferons

Frontiers in Immunology, Journal Year: 2018, Volume and Issue: 9

Published: Sept. 11, 2018

Type I and type II interferons (IFN) are central to both combating virus infection modulating the antiviral immune response. Indeed, an absence of either receptor for IFNs or IFN-y have resulted in increased susceptibility infection, including replication reduced survival. However, emerging area research has shown that there is a dual nature these cytokines. Recent evidence demonstrated immunoregulatory functions during responses. In this review, we address present immunomodulatory critical not only limit initiate appropriate response, but also negatively regulate response minimize tissue damage. Both activating regulatory properties work concert with each other create balanced combats while minimizing collateral damage

Language: Английский

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Natural killer cells in antiviral immunity

Nature reviews. Immunology, Journal Year: 2021, Volume and Issue: 22(2), P. 112 - 123

Published: June 11, 2021

Language: Английский

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Innate Lymphoid Cells: Diversity, Plasticity, and Unique Functions in Immunity

Immunity, Journal Year: 2018, Volume and Issue: 48(6), P. 1104 - 1117

Published: June 1, 2018

Language: Английский

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Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)

European Journal of Immunology, Journal Year: 2021, Volume and Issue: 51(12), P. 2708 - 3145

Published: Dec. 1, 2021

Abstract The third edition of Flow Cytometry Guidelines provides the key aspects to consider when performing flow cytometry experiments and includes comprehensive sections describing phenotypes functional assays all major human murine immune cell subsets. Notably, contain helpful tables highlighting differences between cells. Another useful feature this is analysis clinical samples with examples applications in context autoimmune diseases, cancers as well acute chronic infectious diseases. Furthermore, there are detailing tips, tricks pitfalls avoid. All written peer‐reviewed by leading experts immunologists, making an essential state‐of‐the‐art handbook for basic researchers.

Language: Английский

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CD4 T Helper Cell Subsets and Related Human Immunological Disorders

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(21), P. 8011 - 8011

Published: Oct. 28, 2020

The immune system plays a critical role in protecting hosts from the invasion of organisms. CD4 T cells, as key component system, are central orchestrating adaptive responses. After decades investigation, five major helper cell (Th) subsets have been identified: Th1, Th2, Th17, Treg (T regulatory), and Tfh (follicular helper) cells. Th1 defined by expression lineage cytokine interferon (IFN)-γ master transcription factor T-bet, participate type 1 responses to intracellular pathogens such mycobacterial species viruses; Th2 cytokines interleukin (IL)-4/IL-5/IL-13 GAΤA3, 2 larger extracellular helminths; Th17 IL-17/IL-22 RORγt, 3 including some bacteria fungi; producing IL-21 expressing Bcl6, help B cells produce corresponding antibodies; whereas Foxp3-expressing unlike Th1/Th2/Th17/Tfh exerting their effector functions, regulate maintain homeostasis prevent immunopathology. Interestingly, innate lymphoid (ILCs) found mimic functions three (Th1, Th17) thus can also be divided into subsets: ILC1s, ILC2s, ILC3s. In this review, we will discuss differentiation each subset context ILCs human diseases associated with dysregulation these lymphocyte particularly caused monogenic mutations.

Language: Английский

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Plasticity of innate lymphoid cell subsets

Nature reviews. Immunology, Journal Year: 2020, Volume and Issue: 20(9), P. 552 - 565

Published: Feb. 27, 2020

Language: Английский

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Direct Antiviral Mechanisms of Interferon-Gamma

Immune Network, Journal Year: 2018, Volume and Issue: 18(5)

Published: Jan. 1, 2018

Interferon-gamma (IFNG) is a pleiotropic cytokine that modulates both innate and adaptive immune networks; it the most potent activator of macrophages signature activated T lymphocytes. Though IFNG now appreciated to have multitude roles in modulation broad-spectrum pathogen defense, was originally discovered, named, as secretory factor interferes with viral replication. In contrast prototypical type I interferons produced by any cells upon infection, only specific subsets can produce infection or stimulation antigen mitogen. Still, virtually all respond types interferons. This makes versatile anti-microbial also gives unique position antiviral defense system. The goal this review highlight direct mechanisms IFNG, thereby clarifying its function effective control infections.

Language: Английский

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