Oncogene,
Journal Year:
2021,
Volume and Issue:
40(9), P. 1609 - 1627
Published: Jan. 19, 2021
Abstract
The
hostile
hypoxic
microenvironment
takes
primary
responsibility
for
the
rapid
expansion
of
breast
cancer
tumors.
However,
underlying
mechanism
is
not
fully
understood.
Here,
using
RNA
sequencing
(RNA-seq)
analysis,
we
identified
a
hypoxia-induced
long
noncoding
(lncRNA)
KB-1980E6.3,
which
aberrantly
upregulated
in
clinical
tissues
and
closely
correlated
with
poor
prognosis
patients.
enhanced
lncRNA
KB-1980E6.3
facilitates
stem
cells
(BCSCs)
self-renewal
tumorigenesis
under
both
vitro
vivo.
Mechanistically,
recruited
insulin-like
growth
factor
2
mRNA-binding
protein
1
(IGF2BP1)
to
form
KB-1980E6.3/IGF2BP1/c-Myc
signaling
axis
that
retained
stability
c-Myc
mRNA
through
increasing
binding
IGF2BP1
m6A-modified
coding
region
instability
determinant
(CRD)
mRNA.
In
conclusion,
confirm
maintains
stemness
BCSCs
suggest
disrupting
this
might
provide
new
therapeutic
target
refractory
Science,
Journal Year:
2018,
Volume and Issue:
362(6413)
Published: Oct. 26, 2018
Cancer
chromatin
accessibility
landscape
The
Genome
Atlas
(TCGA)
provides
a
high-quality
resource
of
molecular
data
on
large
variety
human
cancers.
Corces
et
al.
used
recently
modified
assay
to
profile
determine
the
accessible
in
410
TCGA
samples
from
23
cancer
types
(see
Perspective
by
Taipale).
When
were
integrated
with
other
omics
available
for
same
tumor
samples,
inherited
risk
loci
predisposition
revealed,
transcription
factors
and
enhancers
driving
subtypes
patient
survival
differences
identified,
noncoding
mutations
associated
clinical
prognosis
discovered.
Science
,
this
issue
p.
eaav1898
;
see
also
401
Science,
Journal Year:
2018,
Volume and Issue:
361(6409), P. 1341 - 1345
Published: Sept. 28, 2018
Developmental
enhancers
mediate
on/off
patterns
of
gene
expression
in
specific
cell
types
at
particular
stages
during
metazoan
embryogenesis.
They
typically
integrate
multiple
signals
and
regulatory
determinants
to
achieve
precise
spatiotemporal
expression.
Such
can
map
quite
far—one
megabase
or
more—from
the
genes
they
regulate.
How
remote
relay
information
their
target
promoters
is
one
central
mysteries
genome
organization
function.
A
variety
contrasting
mechanisms
have
been
proposed
over
years,
including
enhancer
tracking,
linking,
looping,
mobilization
transcription
factories.
We
argue
that
extreme
versions
these
cannot
account
for
transcriptional
dynamics
precision
seen
living
cells,
tissues,
embryos.
describe
emerging
evidence
dynamic
three-dimensional
hubs
combine
different
elements
classical
models.
Essays in Biochemistry,
Journal Year:
2021,
Volume and Issue:
65(4), P. 625 - 639
Published: April 17, 2021
Majority
of
the
human
genome
is
transcribed
to
RNAs
that
do
not
encode
proteins.
These
non-coding
(ncRNAs)
play
crucial
roles
in
regulating
initiation
and
progression
various
cancers.
Given
importance
ncRNAs,
ncRNAs
cancers
have
been
reviewed
elsewhere.
Thus,
this
review,
we
mainly
focus
on
recent
studies
function,
regulatory
mechanism
therapeutic
potential
including
microRNA
(miRNA),
long
ncRNA
(lncRNA),
circular
RNA
(circRNA)
PIWI
interacting
(piRNA),
different
type
