A novel hypoxic long noncoding RNA KB-1980E6.3 maintains breast cancer stem cell stemness via interacting with IGF2BP1 to facilitate c-Myc mRNA stability DOI Creative Commons
Peng‐Peng Zhu, Fang He, Yixuan Hou

et al.

Oncogene, Journal Year: 2021, Volume and Issue: 40(9), P. 1609 - 1627

Published: Jan. 19, 2021

Abstract The hostile hypoxic microenvironment takes primary responsibility for the rapid expansion of breast cancer tumors. However, underlying mechanism is not fully understood. Here, using RNA sequencing (RNA-seq) analysis, we identified a hypoxia-induced long noncoding (lncRNA) KB-1980E6.3, which aberrantly upregulated in clinical tissues and closely correlated with poor prognosis patients. enhanced lncRNA KB-1980E6.3 facilitates stem cells (BCSCs) self-renewal tumorigenesis under both vitro vivo. Mechanistically, recruited insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) to form KB-1980E6.3/IGF2BP1/c-Myc signaling axis that retained stability c-Myc mRNA through increasing binding IGF2BP1 m6A-modified coding region instability determinant (CRD) mRNA. In conclusion, confirm maintains stemness BCSCs suggest disrupting this might provide new therapeutic target refractory

Language: Английский

ecDNA hubs drive cooperative intermolecular oncogene expression DOI
King L. Hung, Kathryn E. Yost, Liangqi Xie

et al.

Nature, Journal Year: 2021, Volume and Issue: 600(7890), P. 731 - 736

Published: Nov. 24, 2021

Language: Английский

Citations

212
Medulloblastomics revisited: biological and clinical insights from thousands of patients DOI
Volker Hovestadt, Olivier Ayrault, Fredrik J. Swartling

et al.

Nature reviews. Cancer, Journal Year: 2019, Volume and Issue: 20(1), P. 42 - 56

Published: Dec. 9, 2019

Language: Английский

Citations

201
Hacking the Cancer Genome: Profiling Therapeutically Actionable Long Non-coding RNAs Using CRISPR-Cas9 Screening DOI Creative Commons
Roberta Esposito, Núria Bosch, Andrés Lanzós

et al.

Cancer Cell, Journal Year: 2019, Volume and Issue: 35(4), P. 545 - 557

Published: Feb. 28, 2019

Language: Английский

Citations

189
A new era in functional genomics screens DOI
Laralynne Przybyla, Luke A. Gilbert

Nature Reviews Genetics, Journal Year: 2021, Volume and Issue: 23(2), P. 89 - 103

Published: Sept. 20, 2021

Language: Английский

Citations

183
A novel hypoxic long noncoding RNA KB-1980E6.3 maintains breast cancer stem cell stemness via interacting with IGF2BP1 to facilitate c-Myc mRNA stability DOI Creative Commons
Peng‐Peng Zhu, Fang He, Yixuan Hou

et al.

Oncogene, Journal Year: 2021, Volume and Issue: 40(9), P. 1609 - 1627

Published: Jan. 19, 2021

Abstract The hostile hypoxic microenvironment takes primary responsibility for the rapid expansion of breast cancer tumors. However, underlying mechanism is not fully understood. Here, using RNA sequencing (RNA-seq) analysis, we identified a hypoxia-induced long noncoding (lncRNA) KB-1980E6.3, which aberrantly upregulated in clinical tissues and closely correlated with poor prognosis patients. enhanced lncRNA KB-1980E6.3 facilitates stem cells (BCSCs) self-renewal tumorigenesis under both vitro vivo. Mechanistically, recruited insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) to form KB-1980E6.3/IGF2BP1/c-Myc signaling axis that retained stability c-Myc mRNA through increasing binding IGF2BP1 m6A-modified coding region instability determinant (CRD) mRNA. In conclusion, confirm maintains stemness BCSCs suggest disrupting this might provide new therapeutic target refractory

Language: Английский

Citations

178