Inflammation balance in skeletal muscle damage and repair DOI Creative Commons

Huiyin Tu,

Yu‐Long Li

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Jan. 26, 2023

Responding to tissue injury, skeletal muscles undergo the destruction and reconstruction accompanied with inflammation. The immune system recognizes molecules released from or exposed on damaged tissue. In local minor damage, tissue-resident macrophages sequester pro-inflammatory debris prevent initiation of most cases muscle however, a cascade inflammation will be initiated through activation mast cells recruitment blood circulation injured site by recongnization damage-associated molecular patterns (DAMPs) activated complement system. During inflammation, neutrophils scavenge release inflammatory cytokines latter stimulates myoblast fusion vascularization promote repair. On other hand, an abundance chemokines causes profound hyper-inflammation mobilization trigger vicious cycle lead cytokine storm. storm results in elevation cytolytic cytotoxic reactive oxygen species (ROS) aggravates including healthy bystander Severe can rhabdomyolysis cause sepsis-like systemic response syndrome (SIRS) remote organ damage. Therefore, understanding more details involvement factors damage repair provide new precise therapeutic strategies, attenuation promotion

Language: Английский

Locally renewing resident synovial macrophages provide a protective barrier for the joint DOI
Stephan Culemann, Anika Grüneboom, José Ángel Nicolás-Avila

et al.

Nature, Journal Year: 2019, Volume and Issue: 572(7771), P. 670 - 675

Published: Aug. 7, 2019

Language: Английский

Citations

462
Determinants of Resident Tissue Macrophage Identity and Function DOI Creative Commons
Camille Blériot, Svetoslav Chakarov, Florent Ginhoux

et al.

Immunity, Journal Year: 2020, Volume and Issue: 52(6), P. 957 - 970

Published: June 1, 2020

Language: Английский

Citations

397
Establishment and Maintenance of the Macrophage Niche DOI Creative Commons
Martin Guilliams, Guilhem R. Thierry, Johnny Bonnardel

et al.

Immunity, Journal Year: 2020, Volume and Issue: 52(3), P. 434 - 451

Published: March 1, 2020

Language: Английский

Citations

394
Macrophages in health and disease DOI Creative Commons
Matthew D. Park,

Aymeric Silvin,

Florent Ginhoux

et al.

Cell, Journal Year: 2022, Volume and Issue: 185(23), P. 4259 - 4279

Published: Nov. 1, 2022

Language: Английский

Citations

338
Macrophages: The Good, the Bad, and the Gluttony DOI Creative Commons
Ewan A. Ross, Andrew Devitt, Jill R. Johnson

et al.

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: Aug. 12, 2021

Macrophages are dynamic cells that play critical roles in the induction and resolution of sterile inflammation. In this review, we will compile interpret recent findings on plasticity macrophages how these contribute to development non-infectious inflammatory diseases, with a particular focus allergic autoimmune disorders. The inflammation then be examined, emphasizing ability clear apoptotic immune cells. Rheumatoid arthritis (RA) is chronic autoimmune-driven spectrum diseases where persistent results synovial hyperplasia excessive cell accumulation, leading remodeling reduced function affected joints. central pathophysiology RA, driving episodic cycles tissue destruction. RA patients have increased numbers active M1 polarized pro-inflammatory few or inactive M2 type This imbalance macrophage homeostasis main contributor mediators resulting continual activation stromal populations accelerated remodeling. Modulation phenotype remains key therapeutic goal for treatment disease. Intriguingly, intervention glucocorticoids other DMARDs promotes re-polarization an anti-inflammatory phenotype; reprogramming dependent metabolic changes promote phenotypic switching. Allergic asthma associated Th2-polarised airway inflammation, structural large airways, hyperresponsiveness. Macrophage polarization has profound impact pathogenesis, as response allergen exposure regulated by intricate interplay between local factors including cytokines, chemokines danger signals from neighboring Th2-polarized environment characteristic asthma, high levels IL-4 produced locally infiltrating innate lymphoid helper T acquisition alternatively activated M2a macrophages, myriad effects structure. Targeting regulators currently being pursued diseases. re-balancing responses towards pro-resolution thus success response. It long been established apoptosis supports monocyte recruitment sites facilitating subsequent corpse clearance. drives mediates switch polarity macrophages. However, role cell-derived extracellular vesicles (ACdEV) control received remarkably little attention. ACdEV powerful intercellular communication, carrying wealth lipid protein may modulate phenotype, cargo immune-modulating enzymes. such interactions result repair disease different contexts. discuss origin, characterization, activity underlying mechanisms via clearance, order provide new insights into strategies could exploit capabilities agile responsive

Language: Английский

Citations

303
Fibroblast-macrophage reciprocal interactions in health, fibrosis, and cancer DOI Creative Commons
Matthew B. Buechler, Wenxian Fu, Shannon J. Turley

et al.

Immunity, Journal Year: 2021, Volume and Issue: 54(5), P. 903 - 915

Published: May 1, 2021

Language: Английский

Citations

275
Patrolling Alveolar Macrophages Conceal Bacteria from the Immune System to Maintain Homeostasis DOI Creative Commons
Arpan Sharma Neupane,

Michelle Willson,

Andrew Chojnacki

et al.

Cell, Journal Year: 2020, Volume and Issue: 183(1), P. 110 - 125.e11

Published: Sept. 3, 2020

Language: Английский

Citations

251
Liver regeneration and inflammation: from fundamental science to clinical applications DOI
Lara Campana, Hannah Esser, Meritxell Huch

et al.

Nature Reviews Molecular Cell Biology, Journal Year: 2021, Volume and Issue: 22(9), P. 608 - 624

Published: June 2, 2021

Language: Английский

Citations

203
Therapeutic Targeting of Hepatic Macrophages for the Treatment of Liver Diseases DOI Creative Commons
D. van der Heide, Ralf Weiskirchen, Ruchi Bansal

et al.

Frontiers in Immunology, Journal Year: 2019, Volume and Issue: 10

Published: Dec. 3, 2019

Hepatic macrophages play a central role in maintaining homeostasis the liver, as well initiation and progression of liver diseases. can mainly derive from resident hepatic called Kupffer cells or circulating bone marrow-derived monocytes. are self-renewing typically non-migrating stationed sinusoids contrast to originating regulate by mediating immunity against non-pathogenic blood-borne molecules, while participating coordinated immune responses leading pathogen clearance, leukocyte recruitment antigen presentation lymphocytes present vasculature. Monocyte-derived infiltrate into tissue when metabolic toxic damage instigates likely dispensable for replenishing macrophage population homeostasis. In recent years, different populations have been identified with distinct phenotypes discrete functions, far beyond dogma M1 M2 macrophages. pathogenesis acute chronic failure, fibrosis, non-alcoholic fatty disease, alcoholic viral hepatitis, hepatocellular carcinoma, disease resolution. The understanding diseases provides opportunities development targeted therapeutics respective malignancies. This review will summarize current knowledge macrophages, their origin, critical resolution Furthermore, we provide comprehensive overview therapeutic targeting strategies developed treatment

Language: Английский

Citations

190
Current Approaches Targeting the Wound Healing Phases to Attenuate Fibrosis and Scarring DOI Open Access
Amina El Ayadi, Jayson W. Jay, Anesh Prasai

et al.

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(3), P. 1105 - 1105

Published: Feb. 7, 2020

Cutaneous fibrosis results from suboptimal wound healing following significant tissue injury such as severe burns, trauma, and major surgeries. Pathologic skin in scars that are disfiguring, limit normal movement, prevent patient recovery reintegration into society. While various therapeutic strategies have been used to accelerate decrease the incidence of scarring, recent studies targeted molecular regulators each phase healing, including inflammatory, proliferative, remodeling phases. Here, we reviewed most literature elucidating pathways can be reduce with a particular focus on post-burn scarring. Current research targeting inflammatory mediators, epithelial mesenchymal transition, myofibroblast differentiation shows promising results. However, multimodal approach addressing all three phases may provide best outcome.

Language: Английский

Citations

183