Revisiting the Hygiene Hypothesis in the Context of Autoimmunity DOI Creative Commons
Jean‐François Bach

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 11

Published: Jan. 28, 2021

Initially described for allergic diseases, the hygiene hypothesis was extended to autoimmune diseases in early 2000s. A historical overview allows appreciation of development this concept over last two decades and its discussion context evolution. While epidemiological data are convergent, with a few exceptions, underlying mechanisms multiple complex. major question is determine what respective role pathogens, bacteria, viruses, parasites, versus commensals. The intestinal microbiota has elicited much interest, but it cause or consequence autoimmune-mediated inflammation? Our that both pathogens commensals intervene. Another dissect cellular molecular mechanisms. immunoregulatory cytokines, particular interleukin-10 TGF beta probably essential. An important place should also be given ligands innate immunity receptors present viruses parasites acting independently their immunogenicity. Toll-Like Receptor (TLR) well documented including via TLR ligand desensitization.

Language: Английский

The influence of evolutionary history on human health and disease DOI Open Access
Mary Lauren Benton, Abin Abraham, Abigail L. LaBella

et al.

Nature Reviews Genetics, Journal Year: 2021, Volume and Issue: 22(5), P. 269 - 283

Published: Jan. 6, 2021

Language: Английский

Citations

223
A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection DOI Creative Commons
Jean‐Laurent Casanova, Helen C. Su, Laurent Abel

et al.

Cell, Journal Year: 2020, Volume and Issue: 181(6), P. 1194 - 1199

Published: May 13, 2020

Language: Английский

Citations

217
KIR + CD8 + T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19 DOI Creative Commons
Jing Li, Maxim Zaslavsky, Yapeng Su

et al.

Science, Journal Year: 2022, Volume and Issue: 376(6590)

Published: March 8, 2022

In this work, we find that CD8

Language: Английский

Citations

189
Host genetics and infectious disease: new tools, insights and translational opportunities DOI Open Access
Andrew Kwok, Alexander J. Mentzer, Julian C. Knight

et al.

Nature Reviews Genetics, Journal Year: 2020, Volume and Issue: 22(3), P. 137 - 153

Published: Dec. 4, 2020

Language: Английский

Citations

178
African genetic diversity and adaptation inform a precision medicine agenda DOI
Luı́sa Pereira, Léon Mutesa, Paulina Tindana

et al.

Nature Reviews Genetics, Journal Year: 2021, Volume and Issue: 22(5), P. 284 - 306

Published: Jan. 11, 2021

Language: Английский

Citations

144
Human immune diversity: from evolution to modernity DOI Open Access
Adrian Liston, Stéphanie Humblet‐Baron, Darragh Duffy

et al.

Nature Immunology, Journal Year: 2021, Volume and Issue: 22(12), P. 1479 - 1489

Published: Nov. 18, 2021

Language: Английский

Citations

132
Immune-microbe interactions early in life: A determinant of health and disease long term DOI Open Access
Petter Brodin

Science, Journal Year: 2022, Volume and Issue: 376(6596), P. 945 - 950

Published: May 26, 2022

Research on newborn immunity has revealed the importance of cell ontogeny, feto-maternal tolerance, and transfer maternal antibodies. Less is known about postnatal adaptation to environmental exposures. The microbiome its for health have been extensively studied, but it remains unclear how mutually beneficial relationships between commensal microbes human cells first arise are maintained throughout life. Such immune-microbe mutualism, perturbations thereof, most likely a root cause increasing incidences immune-mediated disorders such as allergies autoimmunity across many industrialized nations during past century. In this Review, I discuss our current understanding immune development propose that mismatches among ancestral, early-life, adult environments can explain interactions, dysregulation, increased risks diseases.

Language: Английский

Citations

111
From rare disorders of immunity to common determinants of infection: Following the mechanistic thread DOI Creative Commons
Jean‐Laurent Casanova, Laurent Abel

Cell, Journal Year: 2022, Volume and Issue: 185(17), P. 3086 - 3103

Published: Aug. 1, 2022

The immense interindividual clinical variability during any infection is a long-standing enigma. Inborn errors of IFN-γ and IFN-α/β immunity underlying rare infections with weakly virulent mycobacteria seasonal influenza virus have inspired studies two common infections: tuberculosis COVID-19. A TYK2 genotype impairing production accounts for about 1% cases, autoantibodies neutralizing account 15% critical COVID-19 cases. discovery inborn mechanisms drove the identification monogenic or autoimmune determinants related infections. This “rare-to-common” genetic mechanistic approach to infectious diseases may be heuristic value.

Language: Английский

Citations

105
Genetic adaptation to pathogens and increased risk of inflammatory disorders in post-Neolithic Europe DOI Creative Commons
Gaspard Kerner, Anna‐Lena Neehus, Quentin Philippot

et al.

Cell Genomics, Journal Year: 2023, Volume and Issue: 3(2), P. 100248 - 100248

Published: Jan. 13, 2023

Ancient genomics can directly detect human genetic adaptation to environmental cues. However, it remains unclear how pathogens have exerted selective pressures on genome diversity across different epochs and affected present-day inflammatory disease risk. Here, we use an ancestry-aware approximate Bayesian computation framework estimate the nature, strength, time of onset selection acting 2,879 ancient modern European genomes from last 10,000 years. We found that bulk occurred after start Bronze Age, <4,500 years ago, was enriched in genes relating host-pathogen interactions. Furthermore, detected directional specific leukocytic lineages experimentally demonstrated strongest negatively selected candidate variant immunity genes, lipopolysaccharide-binding protein (

Language: Английский

Citations

61
An HLA map of the world: A comparison of HLA frequencies in 200 worldwide populations reveals diverse patterns for class I and class II DOI Creative Commons

Esteban Arrieta‐Bolaños,

Diana Iraíz Hernández-Zaragoza, Rodrigo Barquera

et al.

Frontiers in Genetics, Journal Year: 2023, Volume and Issue: 14

Published: March 23, 2023

HLA frequencies show widespread variation across human populations. Demographic factors as well selection are thought to have shaped continents. In this study, a worldwide comparison of class I and II diversity was carried out. Multidimensional scaling techniques were applied 50 HLA-A HLA-B (class I) 13 HLA-DRB1 II) first-field in 200 populations from all Our results confirm strong effect geography on the distribution allele groups, with principal coordinates analysis closely resembling geographical location populations, especially those Africa-Eurasia. Conversely, stratify along continuum differentiation less clearly correlated actual geographic location. Double clustering revealed finer intra-continental sub-clusters (e.g., Northern Western Europe vs. South East Europe, North Africa Southwest Asia; West Africa), group patterns characteristic these clusters. Ancient (Austronesian expansion) more recent (Romani people Europe) migrations, extreme (Taiwan indigenous peoples, Native Americans), interregional gene flow (Sámi, Egyptians) also reflected by results. Barrier comparing DST identified genetic discontinuities caused natural barriers or behavior explaining inter borders for II. Overall, progressive reduction African Oceanian American is noted. This unique set confirms previous findings remarkable similarity geography, but shows complex development II, implications both evolutionary studies biomedical research.

Language: Английский

Citations

48