COPD-Like Phenotypes in TBC-Treated Mice Can be Effectively Alleviated via Estrogen Supplement DOI
Wenjuan Zhang,

Yuxin Wang,

Ling Wang

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(39), P. 17227 - 17234

Published: Aug. 21, 2024

Tris(2,3-dibromopropyl) isocyanurate (TBC), recognized as an endocrine disruptor, can cause inflammatory injury to the lung tissue of mice. To investigate specific respiratory effects TBC, male C57BL/6J mice were administered a daily dose 20 mg/kg TBC over 14 days. Postexposure, these developed chronic obstructive pulmonary disease (COPD)-like symptoms characterized by damage and functional impairment. In light antiestrogenic properties we administrated estradiol (E2) its potential protective role against TBC-induced found that coexposure E2 notably mitigated COPD-like phenotypes. Immunohistochemical analysis revealed exposure reduced estrogen receptor alpha (ERα) expression increased nuclear factor kappa-light-chain-enhancer activated B cells (NF-κB) expression, while treatment rebalanced levels ERα NF-κB their normative states. Our findings indicate agent, may contribute pathogenesis COPD through ERα-mediated pathway, but could reverse impairment, providing potentially promising remedial treatment. Given status primary target air pollution, presence compounds like in atmospheric particulates presents significant concern, with exacerbate conditions such pneumonia.

Language: Английский

Convergent gene losses and pseudogenizations in multiple lineages of stomachless fishes DOI Creative Commons
Akira Kato,

Supriya Pipil,

Chihiro Ota

et al.

Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)

Published: April 3, 2024

Abstract The regressive evolution of independent lineages often results in convergent phenotypes. Several teleost groups display secondary loss the stomach, and four gastric genes, atp4a , atp4b pgc pga2 have been co-deleted agastric (stomachless) fish. Analyses genotypic convergence among fishes showed that slc26a9 kcne2 cldn18a vsig1 were or pseudogenized most major groups. also deleted monotreme echidna platypus, respectively. In stomachs sticklebacks, these genes are expressed gland cells surface epithelial cells. An ohnolog cldn18 was retained some teleosts but exhibited an increased non-synonymous substitution when compared with species. These revealed novel gene losses at multiple loci fish, as well a single platypus.

Language: Английский

Citations

6
The β- d - manno -heptoses are immune agonists across kingdoms DOI
Yue Tang, Xiaoying Tian, Min Wang

et al.

Science, Journal Year: 2024, Volume and Issue: 385(6709), P. 678 - 684

Published: Aug. 8, 2024

Bacterial small molecule metabolites such as adenosine-diphosphate-d-

Language: Английский

Citations

6
FishTEDB 2.0: an update fish transposable element (TE) database with new functions to facilitate TE research DOI Creative Commons
Feng Shao,

Minzhi Zeng,

Xiaofei Xu

et al.

Database, Journal Year: 2024, Volume and Issue: 2024

Published: Jan. 1, 2024

We launched the initial version of FishTEDB in 2018, which aimed to establish an open-source, user-friendly, data-rich transposable element (TE) database. Over past 5 years, 1.0 has gained approximately 10 000 users, accumulating more than 450 interactions. With unveiling extensive fish genome data and increasing emphasis on TE research, needs extend richness functions. To achieve above goals, we introduced 33 new species 2.0, encompassing a wide array belonging 48 orders. make updated database functional, added browser visualize positional relationship between TEs genes estimated insertion time different species. In conclusion, released database, designed assist researchers future study functions promote progress biological theories related TEs. Database URL: https://www.fishtedb.com/.

Language: Английский

Citations

5
The acquisition of cold sensitivity during TRPM8 ion channel evolution DOI Creative Commons
Xiancui Lu, Zhihao Yao, Yunfei Wang

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2022, Volume and Issue: 119(21)

Published: May 20, 2022

Significance Adaptation to more severe ambient temperature fluctuations can be considered one of the key innovations terrestrial tetrapods. Our study shows formation functional MHR1-3 domain in transient receptor potential melastatin 8 (TRPM8) bestowed channel with cold sensitivity during water-to-land transition. The evolved found tetrapods serves as an independent apparatus sensitivity. Furthermore, this is necessary for regulatory mechanism pore domain, where efficacy activation largely altered by evolutionary tuning hydrophobicity several residues diversification findings advance understanding cold-sensing emergence evolution and thermodynamic basis TRPM8 activation.

Language: Английский

Citations

22
Lung evolution in vertebrates and the water-to-land transition DOI Creative Commons
Camila Cupello, Tatsuya Hirasawa, Norifumi Tatsumi

et al.

eLife, Journal Year: 2022, Volume and Issue: 11

Published: July 26, 2022

A crucial evolutionary change in vertebrate history was the Palaeozoic (Devonian 419–359 million years ago) water-to-land transition, allowed by key morphological and physiological modifications including acquisition of lungs. Nonetheless, origin early evolution lungs remain highly controversial, particularly whether ancestral state paired or unpaired. Due to rarity fossil soft tissue preservation, lung can only be traced based on extant phylogenetic bracket. Here we investigate, for first time, morphology extensive developmental series living lunged osteichthyans using synchrotron x-ray microtomography histology. Our results shed light primitive as unpaired, evolving truly lineage towards tetrapods. The transition confronted profound challenges were decisive increasing surface area pulmonary compliance volume, especially during air-breathing land.

Language: Английский

Citations

22
Hox, homology, and parsimony: An organismal perspective DOI Creative Commons
Andreas Wanninger

Seminars in Cell and Developmental Biology, Journal Year: 2023, Volume and Issue: 152-153, P. 16 - 23

Published: Jan. 18, 2023

Hox genes are important regulators in animal development. They often show a mosaic of conserved (e.g., longitudinal axis patterning) and lineage-specific novel functions development skeletal, sensory, or locomotory systems). Despite extensive research over the past decades, it remains controversial at which node tree life cluster evolved. Its presence already last common metazoan ancestor has been proposed, although genomes both putative earliest extant offshoots, ctenophores poriferans, devoid sequences. The lack supposedly "simple"-built poriferans their low number cnidarians basally branching bilaterians, xenacoelomorphs, seems to support classical notion that is correlated with degree complexity. However, 4-fold increase xiphosurans, chelicerate clade, as well situation some teleost fishes multitude compared to, e.g., human, demonstrates, there no per se direct correlation between organismal complexity number. Traditional approaches have tried base homology on morphological level shared expression profiles individual genes, but recent data shown that, particular respect other regulatory complex gene-gene interactions rather than signatures alone responsible for shaping traits during ontogeny. Accordingly, sound assessments reconstructions character evolution organ system level, additional independent datasets morphological, developmental) need be included any such analyses. If supported by solid data, proposed structural should regarded valid not rejected solely grounds non-parsimonious distribution given phylogenetic topology.

Language: Английский

Citations

13
The distribution and function of teleost IgT DOI

Haoyue Xu,

Zixuan Wang, Yuqing Li

et al.

Fish & Shellfish Immunology, Journal Year: 2023, Volume and Issue: 144, P. 109281 - 109281

Published: Dec. 11, 2023

Language: Английский

Citations

13
Whole-genome Sequencing Reveals Autooctoploidy in Chinese Sturgeon and Its Evolutionary Trajectories DOI Creative Commons
Binzhong Wang, Bin Wu, Xueqing Liu

et al.

Genomics Proteomics & Bioinformatics, Journal Year: 2023, Volume and Issue: 22(1)

Published: Dec. 13, 2023

The order Acipenseriformes, which includes sturgeons and paddlefishes, represents "living fossils" with complex genomes that are good models for understanding whole-genome duplication (WGD) ploidy evolution in fishes. Here, we sequenced assembled the first high-quality chromosome-level genome octoploid Acipenser sinensis (Chinese sturgeon), a critically endangered species also poorly understood group Acipenseriformes. Our results show A. is autooctoploid containing four kinds of octovalents (8n), hexavalent (6n), two tetravalents (4n), divalent (2n). An analysis taking into account delayed rediploidization reveals composition Chinese sturgeon from rounds homologous WGDs, further provides insights timing its evolution. This study resource Acipenseriformes compositions evolutionary trajectories polyploid

Language: Английский

Citations

11
Family evolution and functional divergence of bony fish-specific Gig1 homologs DOI Creative Commons

Lili An,

Xiu-Ying Gong,

Dan Cheng

et al.

Water Biology and Security, Journal Year: 2025, Volume and Issue: unknown, P. 100382 - 100382

Published: March 1, 2025

Language: Английский

Citations

0
Long-read sequencing reveals novel transcript diversity in Polypterus senegalus DOI Creative Commons
Jeongwoen Shin, Bo‐Mi Kim, Seung Hwan Lee

et al.

Animal Cells and Systems, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 10

Published: March 31, 2025

Citations

0