Transmission, viral kinetics and clinical characteristics of the emergent SARS-CoV-2 Delta VOC in Guangzhou, China

EClinicalMedicine, Journal Year: 2021, Volume and Issue: 40, P. 101129 - 101129

Published: Sept. 12, 2021

BackgroundA novel variant of SARS-CoV-2, the Delta concern (VOC, also known as lineage B.1.617.2), is fast becoming dominant strain globally. We reported epidemiological, viral, and clinical characteristics hospitalized patients infected with VOC during local outbreak in Guangzhou, China.MethodsWe extracted epidemiological information pertaining to 159 cases across seven transmission generations between May 21 June 18, 2021. The whole chain was described. Kinetics viral load were compared a cohort wild-type infection 2020 admitted Guangzhou Eighth People's Hospital.FindingsThere four within first ten days. yielded significantly shorter incubation period (4.0 vs. 6.0 days), higher (20.6 34.0, cycle threshold ORF1a/b gene), longer duration shedding pharyngeal swab samples (14.0 8.0 days) strain. In critical illness, proportion over age 60 group than (100.0% 69.2%, p = 0.03). had risk deterioration status (hazards ratio 2.98 [95%CI 1.29-6.86]; 0.01).InterpretationInfection characterized by markedly increased transmissibility, loads disease progression strain, calling for more intensive prevention control measures contain future outbreaks.FundingNational Grand Program, National Natural Science Foundation China, Guangdong Provincial Department Technology, Laboratory

Language: Английский

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Impact of the Delta variant on vaccine efficacy and response strategies

Expert Review of Vaccines, Journal Year: 2021, Volume and Issue: 20(10), P. 1201 - 1209

Published: Sept. 7, 2021

The Delta variant of SARS-CoV-2 has caused a new wave the COVID-19 epidemic in many countries. It is most infectious to date, and its high infectivity means that higher proportion population needs be vaccinated reduce disease burden, which poses substantial public health challenge.The evolution reviewed, including an overview Plus with K417N mutation RBD, may confer improved immune evasion ability. Decreases serum neutralizing antibody titers after vaccination against were greater than those Alpha but less Beta. protective efficacy existing vaccines have declined related number doses time since vaccination.The currently used are effective hospitalization/severe due variant. Accelerating popularization vaccination, improving coverage rate, implementation intervention measures, such as wearing masks, control spread other variants. However, alone without measures lead continuous emergence

Language: Английский

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Tracking SARS-CoV-2 Omicron diverse spike gene mutations identifies multiple inter-variant recombination events

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: April 26, 2022

Abstract The current pandemic of COVID-19 is fueled by more infectious emergent Omicron variants. Ongoing concerns variants include possible recombinants, as genome recombination an important evolutionary mechanism for the emergence and re-emergence human viral pathogens. In this study, we identified diverse events between two major subvariants (BA.1 BA.2) other concern (VOCs) interest (VOIs), suggesting that co-infection subsequent play roles in ongoing evolution SARS-CoV-2. Through scanning high-quality completed spike gene sequences, 18 core mutations BA.1 (frequency >99%) 27 BA.2 (nine than BA.1) were identified, which 15 are specific to Omicron. share nine common amino acid (three protein with most VOCs, a origin from these VOCs. There three Alpha-related BA.2, phylogenetically closer Alpha Revertant found some dominant >95%) BA.1. Most notably, multiple characteristic Delta have been also “Deltacron”-like Variants isolated since November 11, 2021 South Africa, implies occurring Monitoring evolving SARS-CoV-2 genomes especially critically recognition abrupt changes attributes including its epitopes may call vaccine modifications.

Language: Английский

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Acquisition of the L452R Mutation in the ACE2-Binding Interface of Spike Protein Triggers Recent Massive Expansion of SARS-CoV-2 Variants

Journal of Clinical Microbiology, Journal Year: 2021, Volume and Issue: 59(11)

Published: Aug. 11, 2021

We report that there is a recent global expansion of numerous independent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with mutation L452R in the receptor-binding domain (RBD) spike protein. The massive emergence was first linked to lineage B.1.427/B.1.429 (clade 21C) has been spreading California since November and December 2020, originally named CAL.20C currently variant interest epsilon.

Language: Английский

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Immune Evasion of SARS-CoV-2 Emerging Variants: What Have We Learnt So Far?

Viruses, Journal Year: 2021, Volume and Issue: 13(7), P. 1192 - 1192

Published: June 22, 2021

Despite the slow evolutionary rate of SARS-CoV-2 relative to other RNA viruses, its massive and rapid transmission during COVID-19 pandemic has enabled it acquire significant genetic diversity since first entered human population. This led emergence numerous variants, some them recently being labeled “variants concern” (VOC), due their potential impact on transmission, morbidity/mortality, evasion neutralization by antibodies elicited infection, vaccination, or therapeutic application. The evade is result target epitopes generated accumulation mutations in spike protein. While three globally recognized VOCs (Alpha B.1.1.7, Beta B.1.351, Gamma P.1) remain sensitive albeit at reduced levels sera convalescent individuals recipients several anti-COVID19 vaccines, effect variability much more evident capacity monoclonal antibodies. newly VOC Delta lineage B.1.617.2, as well locally accepted (Epsilon B.1.427/29-US B1.1.7 with E484K-UK) are indicating necessity close monitoring new variants a global level. characteristics, mutational patterns, role play immune summarized this review.

Language: Английский

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