Nonresolving inflammation redux

Immunity, Journal Year: 2022, Volume and Issue: 55(4), P. 592 - 605

Published: April 1, 2022

Language: Английский

---

Allostasis, Action, and Affect in Depression: Insights from the Theory of Constructed Emotion

Annual Review of Clinical Psychology, Journal Year: 2022, Volume and Issue: 18(1), P. 553 - 580

Published: May 9, 2022

The theory of constructed emotion is a systems neuroscience approach to understanding the nature emotion. It also general theoretical framework guide hypothesis generation for how actions and experiences are as brain continually anticipates metabolic needs attempts meet those before they arise (termed allostasis). In this review, we introduce hypothesize that allostatic dysregulation trans-disorder vulnerability mental physical illness. We then review published findings consistent with several symptoms in major depressive disorder (MDD), such fatigue, distress, context insensitivity, reward motor retardation, associated persistent problems energy regulation. Our transforms current MDD resulting from enhanced emotional reactivity combined reduced cognitive control and, doing so, offers novel hypotheses regarding development, progression, treatment, prevention MDD.

Language: Английский

---

Somatic symptom disorder in patients with post-COVID-19 neurological symptoms: a preliminary report from the somatic study (Somatic Symptom Disorder Triggered by COVID-19)

Journal of Neurology Neurosurgery & Psychiatry, Journal Year: 2022, Volume and Issue: 93(11), P. 1174 - 1180

Published: Aug. 25, 2022

Objectives To assess the diagnosis of somatic symptom disorder (SSD) in patients with unexplained neurological symptoms occurring after SARS-CoV-2 infection, also referred to as long COVID. Design Single-centre observational study. Participants Adult experiencing long-lasting mild Of 58 consecutive our centre, 50 were included. Intervention Patients contacted for a standardised psychometric evaluation by phone, followed self-survey. Main outcome Positive SSD according criteria Diagnostic and Statistical Manual Mental Disorders-5 (DSM-5). Results Although did not meet DSM-5 functional specifically, based on was positive 32 (64%) patients. In remaining 18 patients, considered possible given high score diagnostic scales. Physical examination normal all. Brain MRI showed unspecific minor white matter hyperintensities 8/46 Neuropsychological assessment exclusively impairment attention 14 out 15 tested discrepancy their major subjective complaint. Forty-five (90%) met Chronic Fatigue Syndrome. Seventeen (32%) screened mood-anxiety disorders, 19 (38%) had history prior 27 (54%) reported past trauma. Additional self-survey highlighted post-traumatic stress 12/43 (28%), levels alexithymia traits perfectionism. Long-lasting impact rate insomnia (29/43, 67%), psychiatric follow-up (28/50, 56%) work or pay loss (25/50, 50%). Conclusion A majority COVID may require specific management. Trial registration number NCT04889313 .

Language: Английский

---

Sickness behaviour and depression: An updated model of peripheral-central immunity interactions

Brain Behavior and Immunity, Journal Year: 2023, Volume and Issue: 111, P. 202 - 210

Published: April 17, 2023

Current research into mood disorders indicates that circulating immune mediators participating in the pathophysiology of chronic somatic have potent influences on brain function. This paradigm has brought to fore use anti-inflammatory therapies as adjunctive standard antidepressant therapy improve treatment efficacy, particularly subjects do not respond medication. Such new practice requires biomarkers tailor these those most likely benefit but also validated mechanisms action describing interaction between peripheral immunity and function optimize target intervention. These are generally studied preclinical models try recapitulate human disease, MDD, through peripherally induced sickness behaviour. In this proposal paper, after an appraisal data rodent their adherence clinical cohorts, we put forward a modified model periphery-brain interactions goes beyond currently established view microglia cells drivers depression. Instead, suggest that, for patients with mild levels inflammation, barriers primary actors disease resistance. We then highlight gaps novel lines research.

Language: Английский

---

Immune mechanisms of depression in rheumatoid arthritis

Nature Reviews Rheumatology, Journal Year: 2023, Volume and Issue: 19(12), P. 790 - 804

Published: Nov. 3, 2023

Language: Английский

---