Transplant Immunology, Journal Year: 2024, Volume and Issue: 86, P. 102102 - 102102
Published: Aug. 1, 2024
Language: Английский
Citations
0Implementing CRISPR/Cas9 into the Study of Anticancer Drug Resistance
Interdisciplinary cancer research, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Citations
0Testing Oncolytic Myxoma Virus in Immunocompetent Mouse Model for Cancer Therapy
Methods in molecular biology, Journal Year: 2024, Volume and Issue: unknown, P. 353 - 360
Published: Dec. 2, 2024
Language: Английский
Citations
0Self-Activated Cascade-Tailored Small Molecule for Cancer Therapy, Companion Diagnostics, and “Theranostic Correlation” Evaluation
Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(51), P. 20147 - 20151
Published: Dec. 9, 2024
Companion diagnostics (CDx) have emerged as valuable tools for monitoring biomarkers essential drug activation and therapeutic response, enabling personalized treatment strategies. However, the current FDA-approved CDx is limited to in vitro testing, making it challenging assess real-time efficacy. Moreover, evaluation of responses solely based on release or may disregard tumor heterogeneity. To address these challenges, we developed a cascade-responsive small molecule Cbl-DEVD-Hcy simultaneous cancer therapy timely effectiveness vivo. Upon cleavage by tumor-cell-overexpressed carboxylesterase, chlorambucil (Cbl) can be released induce cell apoptosis activate caspase-3. This triggers production near-infrared dye Hcy-NH2, generating both fluorescence photoacoustic signals process. The excellent "theranostic correlation" between imaging signal demonstrated orthotopic breast tumors, highlights potential effective precise body.
Language: Английский
Citations
0The Emerging Landscape of Mouse Bladder Cancer Models
Published: Jan. 1, 2024
Language: Английский
Citations
0