The NRC0 gene cluster of sensor and helper NLR immune receptors is functionally conserved across asterid plants DOI Creative Commons
Toshiyuki Sakai, Mauricio P. Contreras, Claudia Martínez‐Anaya

et al.

The Plant Cell, Journal Year: 2024, Volume and Issue: 36(9), P. 3344 - 3361

Published: June 4, 2024

Nucleotide-binding domain and leucine-rich repeat-containing receptor (NLR) proteins can form complex networks to confer innate immunity. An NLR-REQUIRED FOR CELL DEATH (NRC) is a phylogenetically related node that functions downstream of massively expanded network disease resistance protect against multiple plant pathogens. In this study, we used phylogenomic methods reconstruct the macroevolution NRC family. One NRCs, termed NRC0, only family member shared across asterid plants, leading us investigate its evolutionary history genetic organization. several species, NRC0 genetically clustered with other NLRs are NRC-dependent genes. This prompted hypothesize ancestral state an NLR helper-sensor gene cluster was present early during evolution. We provide support for hypothesis by demonstrating essential hypersensitive cell death induced linked sensor partners in 4 divergent species: tomato (Solanum lycopersicum), wild sweet potato (Ipomoea trifida), coffee (Coffea canephora), carrot (Daucus carota). addition, activation leads higher-order formation similar NRCs. Our findings map out contrasting dynamics over last 125 million years, from functionally conserved massive dispersed network.

Language: Английский

The highly diverse antiphage defence systems of bacteria DOI
Héloïse Georjon, Aude Bernheim

Nature Reviews Microbiology, Journal Year: 2023, Volume and Issue: 21(10), P. 686 - 700

Published: July 17, 2023

Language: Английский

Citations

230
A host of armor: Prokaryotic immune strategies against mobile genetic elements DOI Creative Commons
David Mayo-Muñoz, Rafael Pinilla‐Redondo, Nils Birkholz

et al.

Cell Reports, Journal Year: 2023, Volume and Issue: 42(7), P. 112672 - 112672

Published: June 21, 2023

Prokaryotic adaptation is strongly influenced by the horizontal acquisition of beneficial traits via mobile genetic elements (MGEs), such as viruses/bacteriophages and plasmids. However, MGEs can also impose a fitness cost due to their often parasitic nature differing evolutionary trajectories. In response, prokaryotes have evolved diverse immune mechanisms against MGEs. Recently, our understanding abundance diversity prokaryotic systems has greatly expanded. These defense degrade invading material, inhibit genome replication, or trigger abortive infection, leading population protection. this review, we highlight these strategies, focusing on most recent discoveries. The study defenses not only sheds light microbial evolution but uncovers novel enzymatic activities with promising biotechnological applications.

Language: Английский

Citations

65
The NLR family of innate immune and cell death sensors DOI Creative Commons
Balamurugan Sundaram, Rebecca E. Tweedell, Sivakumar Prasanth Kumar

et al.

Immunity, Journal Year: 2024, Volume and Issue: 57(4), P. 674 - 699

Published: April 1, 2024

Nucleotide-binding oligomerization domain (NOD)-like receptors, also known as nucleotide-binding leucine-rich repeat receptors (NLRs), are a family of cytosolic pattern recognition that detect wide variety pathogenic and sterile triggers. Activation specific NLRs initiates pro- or anti-inflammatory signaling cascades the formation inflammasomes—multi-protein complexes induce caspase-1 activation to drive inflammatory cytokine maturation lytic cell death, pyroptosis. Certain inflammasomes act integral components larger death complexes—PANoptosomes—driving another form PANoptosis. Here, we review current understanding evolution, structure, function in health disease. We discuss concept NLR networks their roles driving immunity. An improved mechanistic may provide therapeutic strategies applicable across infectious diseases cancer.

Language: Английский

Citations

61
The evolutionary success of regulated cell death in bacterial immunity DOI
François Rousset, Rotem Sorek

Current Opinion in Microbiology, Journal Year: 2023, Volume and Issue: 74, P. 102312 - 102312

Published: April 6, 2023

Language: Английский

Citations

60
NLR receptors in plant immunity: making sense of the alphabet soup DOI Creative Commons
Mauricio P. Contreras, Daniel Lüdke, Hsuan Pai

et al.

EMBO Reports, Journal Year: 2023, Volume and Issue: 24(10)

Published: Aug. 21, 2023

Plants coordinately use cell-surface and intracellular immune receptors to perceive pathogens mount an response. Intracellular events of pathogen recognition are largely mediated by the nucleotide binding leucine rich-repeat (NLR) classes. Upon perception, NLRs trigger a potent broad-spectrum reaction, usually accompanied form programmed cell death termed hypersensitive Some plant act as multifunctional singleton which combine detection signaling. However, can also function in higher order pairs networks functionally specialized interconnected receptors. In this article, we cover basic aspects NLR biology with emphasis on networks. We highlight some recent advances structure, function, activation discuss emerging topics such modulator NLRs, suppression bioengineering. Multi-disciplinary approaches required disentangle how these receptor evolve. Answering questions holds potential deepen our understanding system unlock new era disease resistance breeding.

Language: Английский

Citations

59
A conserved family of immune effectors cleaves cellular ATP upon viral infection DOI Creative Commons
François Rousset, Erez Yirmiya,

Shahar Nesher

et al.

Cell, Journal Year: 2023, Volume and Issue: 186(17), P. 3619 - 3631.e13

Published: Aug. 1, 2023

Language: Английский

Citations

48
Plant and prokaryotic TIR domains generate distinct cyclic ADPR NADase products DOI Creative Commons
Adam M. Bayless, Sisi Chen, Sam C. Ogden

et al.

Science Advances, Journal Year: 2023, Volume and Issue: 9(11)

Published: March 17, 2023

Toll/interleukin-1 receptor (TIR) domain proteins function in cell death and immunity. In plants bacteria, TIR domains are often enzymes that produce isomers of cyclic adenosine 5′-diphosphate–ribose (cADPR) as putative immune signaling molecules. The identity functional conservation cADPR isomer signals is unclear. A previous report found a plant could cross-activate the prokaryotic Thoeris TIR–immune system, suggesting TIR-immune signals. Here, we generate autoactive TIRs test converse hypothesis: Do also immunity? Using planta vitro assays, find overlapping sets further clarify how activate system via producing 3′cADPR. This study demonstrates requirements for systems distinct across kingdoms diversity small-molecule products.

Language: Английский

Citations

46
Conservation and similarity of bacterial and eukaryotic innate immunity DOI
Hannah E. Ledvina, Aaron T. Whiteley

Nature Reviews Microbiology, Journal Year: 2024, Volume and Issue: 22(7), P. 420 - 434

Published: Feb. 28, 2024

Language: Английский

Citations

24
CARD domains mediate anti-phage defence in bacterial gasdermin systems DOI
Tanita Wein, Adi Millman, Kathrin Lange

et al.

Nature, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Language: Английский

Citations

2
Bacteriophage strategies for overcoming host antiviral immunity DOI Creative Commons

Zhengyu Gao,

Yue Feng

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: June 8, 2023

Phages and their bacterial hosts together constitute a vast diverse ecosystem. Facing the infection of phages, prokaryotes have evolved wide range antiviral mechanisms, phages in turn adopted multiple tactics to circumvent or subvert these mechanisms survive. An in-depth investigation into interaction between bacteria not only provides new insight ancient coevolutionary conflict them but also produces precision biotechnological tools based on anti-phage systems. Moreover, more complete understanding is critical for phage-based antibacterial measures. Compared studies counter-defense strategies by been little slow, achieved important advances recent years. In this review, we highlight numerous intracellular immune systems as well countermeasures employed with an emphasis bacteriophage response host immunity.

Language: Английский

Citations

28