Nature Reviews Molecular Cell Biology, Journal Year: 2024, Volume and Issue: 25(12), P. 979 - 1000
Published: Oct. 3, 2024
Language: Английский
Nature Medicine, Journal Year: 2024, Volume and Issue: 30(2), P. 360 - 372
Published: Feb. 1, 2024
Language: Английский
Citations
106
Nature Aging, Journal Year: 2024, Volume and Issue: 4(2), P. 231 - 246
Published: Jan. 19, 2024
Language: Английский
Citations
66
Frontiers in Aging, Journal Year: 2024, Volume and Issue: 5
Published: Jan. 15, 2024
The inexorability of the aging process has sparked curiosity human beings since ancient times. However, despite this interest and extraordinary scientific advances in field, complexity hampered its comprehension. In context, Hallmarks Aging were defined 2013 with aim establishing an organized, systematic integrative view topic, which would serve as a conceptual framework for research. Ten years later promoted by progress area, updated version included three new hallmarks while maintaining original scope. review is to determine what extent achieved purpose that gave rise them. For aim, we have reviewed literature citing any two versions conclude they served not only research but also related areas knowledge. Finally, discusses candidates become part list, analyzing evidence supports whether should or be incorporated.
Language: Английский
Citations
21
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: July 16, 2024
DNA methylation (DNAm) is one of the most reliable biomarkers aging across mammalian tissues. While age-dependent global loss DNAm has been well characterized, gain less characterized. Studies have demonstrated that CpGs which with age are enriched in Polycomb Repressive Complex 2 (PRC2) targets. However, whole-genome examination all PRC2 targets as determination pan-tissue or tissue-specific nature these associations lacking. Here, we show low-methylated regions (LMRs) highly bound by embryonic stem cells (PRC2 LMRs) examined somatic mitotic cells. We estimated this epigenetic change represents around 90% genome-wide. Therefore, propose "PRC2-AgeIndex," defined average LMRs, a universal biomarker cellular can distinguish effect different anti-aging interventions.
Language: Английский
Citations
19
Aging Cell, Journal Year: 2024, Volume and Issue: 23(8)
Published: May 15, 2024
Abstract Beyond mere prognostication, optimal biomarkers of aging provide insights into qualitative and quantitative features biological might, therefore, offer useful information for the testing and, ultimately, clinical use gerotherapeutics. We aimed to develop a proteomic clock (PAC) all‐cause mortality risk as proxy age. Data were from UK Biobank Pharma Proteomics Project, including 53,021 participants aged between 39 70 years 2923 plasma proteins assessed using Olink Explore 3072 assay®. 10.9% died during mean follow‐up 13.3 years, with age at death 70.1 years. The Spearman correlation PAC chronological was 0.77. showed robust age‐adjusted associations predictions onset various diseases in general disease‐free participants. associated deviation enriched several processes related hallmarks aging. Our results expand previous findings by showing that acceleration, based on PAC, strongly predicts incident disease outcomes. Particularly, it facilitates evaluation multiple conditions population, thereby, contributing prevention initial diseases, which vary among individuals may subsequently lead additional comorbidities.
Language: Английский
Citations
15
Nature Immunology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 29, 2025
A comprehensive understanding of the evolution immune landscape in humans across entire lifespan at single-cell transcriptional and protein levels, during development, maturation senescence is currently lacking. We recruited a total 220 healthy volunteers from Shanghai Pudong Cohort (NCT05206643), spanning 13 age groups 0 to over 90 years, profiled their peripheral cells through RNA-sequencing coupled with single T cell B receptor sequencing, high-throughput mass cytometry, bulk flow cytometry validation experiments. revealed that were most strongly affected by experienced intensive rewiring cell-cell interactions specific age. Different subsets displayed different aging patterns both transcriptomes repertoires; examples included GNLY+CD8+ effector memory cells, which exhibited highest clonal expansion among all distinct functional signatures children elderly; CD8+ MAIT reached peaks relative abundance, diversity antibacterial capability adolescents then gradually tapered off. Interestingly, we identified experimentally verified previously unrecognized 'cytotoxic' subset was enriched children. Finally, an prediction model developed based on lifecycle-wide data can evaluate status individuals identify those disturbed functions. Our work provides valuable insights resources for further system whole human lifespan.
Language: Английский
Citations
4
Nature Aging, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 3, 2025
Abstract While observational studies and small pilot trials suggest that vitamin D, omega-3 exercise may slow biological aging, larger clinical testing these treatments individually or in combination are lacking. Here, we report the results of a post hoc analysis among 777 participants DO-HEALTH trial on effect D (2,000 IU per day) and/or (1 g home program four next-generation DNA methylation (DNAm) measures aging (PhenoAge, GrimAge, GrimAge2 DunedinPACE) over 3 years. Omega-3 alone slowed DNAm clocks PhenoAge, DunedinPACE, all three had additive benefits PhenoAge. Overall, from baseline to year 3, standardized effects ranged 0.16 0.32 units (2.9–3.8 months). In summary, our indicates protective treatment slowing years across several clocks, with an omega-3, based
Language: Английский
Citations
4
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown
Published: July 17, 2023
Individuals, organs, tissues, and cells age in diverse ways throughout the lifespan. Epigenetic clocks attempt to quantify differential aging between individuals, but they typically summarize as a single measure, ignoring within-person heterogeneity. Our aim was develop novel systems-based methylation that, when assessed blood, capture distinct physiological systems. We combined supervised unsupervised machine learning methods link DNA methylation, system-specific clinical chemistry functional measures, mortality risk. This yielded panel of 11 scores- Heart, Lung, Kidney, Liver, Brain, Immune, Inflammatory, Blood, Musculoskeletal, Hormone, Metabolic. Each system score predicted wide variety outcomes, phenotypes, conditions specific respective system. also scores into composite Systems Age clock that is predictive across systems an unbiased manner. Finally, we showed clustered individuals unique subtypes had different patterns age-related disease decline. Overall, our biological based epigenetic framework captures multiple using blood draw assay may inform development more personalized approaches for improving quality life.
Language: Английский
Citations
29
Clinical Nutrition, Journal Year: 2023, Volume and Issue: 43(1), P. 1 - 10
Published: Nov. 15, 2023
Language: Английский
Citations
25
Communications Biology, Journal Year: 2023, Volume and Issue: 6(1)
Published: Oct. 26, 2023
Biological age captures physiological deterioration better than chronological and is amenable to interventions. Blood-based biomarkers have been identified as suitable candidates for biological estimation. This study aims improve estimation using machine learning models a feature-set of 60 circulating available from the UK Biobank (n = 306,116). We implement an Elastic-Net derived Cox model with 25 selected predict mortality risk (C-Index 0.778; 95% CI [0.767-0.788]), which outperforms well-known blood-biomarker based PhenoAge 0.750; [0.739-0.761]), providing C-Index lift 0.028 representing 11% relative increase in predictive value. Importantly, we then show that common clinical assay panels, few biomarkers, alongside imputation on full set does not substantially degrade accuracy theoretical maximum achievable biomarkers. estimated equivalent within same-sex population corresponds individual's risk. Values ranged between 20-years younger older individuals' age, exposing magnitude ageing signals contained blood markers. Thus, demonstrate practical cost-efficient method estimating improved measure Age, general population.
Language: Английский
Citations
23