Single-cell parallel analysis of DNA damage and transcriptome reveals selective genome vulnerability DOI
Dong-sheng Bai,

Zhenkun Cao,

Nivedita Attada

et al.

Nature Methods, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Language: Английский

Single-cell investigation of lead toxicity from neurodevelopment to neurodegeneration: Current review and future opportunities DOI Creative Commons
Maureen M. Sampson, Rachel K. Morgan, Steven A. Sloan

et al.

Current Opinion in Toxicology, Journal Year: 2024, Volume and Issue: 38, P. 100464 - 100464

Published: Feb. 2, 2024

Language: Английский

Citations

4
Introducing the Role of Genotoxicity in Neurodegenerative Diseases and Neuropsychiatric Disorders DOI Open Access
Glen E. Kisby,

David M. Wilson,

Peter S. Spencer

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7221 - 7221

Published: June 29, 2024

Decades of research have identified genetic and environmental factors involved in age-related neurodegenerative diseases and, to a lesser extent, neuropsychiatric disorders. Genomic instability, i.e., the loss genome integrity, is common feature among both (mayo-trophic lateral sclerosis, Parkinson's disease, Alzheimer's disease) psychiatric (schizophrenia, autism, bipolar depression) instability associated with accumulation persistent DNA damage activation response (DDR) pathways, as well pathologic neuronal cell or senescence. Typically, DDR signaling ensures that genomic proteomic homeostasis are maintained dividing cells, including neural progenitors, post-mitotic neurons. However, dysregulation these protective responses, part due aging insults, contributes progressive development and/or In this Special Issue, we introduce highlight overlap between disorders, emerging clinical, genomic, molecular evidence for contributions aberrant repair. Our goal illuminate importance subject uncover possible treatment prevention strategies relevant devastating brain diseases.

Language: Английский

Citations

4
Beyond the usual suspects: multi-factorial computational models in the search for neurodegenerative disease mechanisms DOI Creative Commons
Ahmed Faraz Khan, Yasser Iturria‐Medina

Translational Psychiatry, Journal Year: 2024, Volume and Issue: 14(1)

Published: Sept. 23, 2024

Language: Английский

Citations

4
Tau mediates the reshaping of the transcriptional landscape toward intermediate Alzheimer’s disease stages DOI Creative Commons
Giacomo Siano, Martina Varisco, Marco Terrigno

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 3, 2025

Recent research revealed that Tau plays critical roles in various neuronal functions. We previously demonstrated destabilization and nuclear delocalization of alter the expression glutamatergic genes, mediating early damage. In this study, we discovered changes availability are linked to global alterations gene affect multiple pathways. Comparison with human temporal region showed Tau-dependent modulation closely resembles intermediate stages Alzheimer's disease (AD) precede definitive pathological condition. Furthermore, identified chromatin remodeling pathway as being significantly affected by both our cellular model AD brains, reductions heterochromatin markers. Our findings indicate is able globally transcriptome its subcellular unbalance development. addition, found architecture during progression AD. These results provide new insights into molecular mechanisms underlying development highlight central role contribution process.

Language: Английский

Citations

0
Single-cell parallel analysis of DNA damage and transcriptome reveals selective genome vulnerability DOI
Dong-sheng Bai,

Zhenkun Cao,

Nivedita Attada

et al.

Nature Methods, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Language: Английский

Citations

0