Unmasking the hidden impact of viruses on tuberculosis risk DOI Creative Commons
Fatoumatta Darboe, Josephine F. Reijneveld, David P. Maison

et al.

Trends in Immunology, Journal Year: 2024, Volume and Issue: 45(9), P. 649 - 661

Published: Aug. 23, 2024

SignificanceFactors associated with tuberculosis (TB) risk remain poorly defined. Studies indicate that viral infections can heighten the of transitioning from latent Mycobacterium (Mtb) infection to TB. Innate antiviral responses, particularly increased type I interferon signaling, correlate elevated TB and bacterial load following Mtb infection. HIV-1 illustrates how a chronic amplify mortality, but relationship between may extend beyond HIV-1. Identifying specific families pathogenic mechanisms heightened/persistent remains key research area.HighlightsViral co-infections in (Mtb)-exposed individuals are potentially factor for pathogenesis.Some infections, such as human immunodeficiency virus 1 (HIV-1) cytomegalovirus (CMV), increase risk. However, it is unclear whether different viruses impart unique or shared mechanisms.Viruses modulate both systemic local tissue environments ways risk.There an urgent need experimental models approaches help define impact emerging re-emerging epidemics on incidence mortality TB-endemic settings.AbstractTuberculosis leading cause infectious disease. In this opinion article, we focus accumulating scientific evidence indicating contribute progression, possibly allowing novel preventive interventions. Viruses remodel mammalian immune system, modulating reactivating microbes (Mtb). Evidence mixed regarding emergent SARS-CoV-2 Therefore, posit important knowledge gaps include elucidating which these provide mechanisms. We also propose potential future contribution pathogenesis.

Language: Английский

Neutrophil extracellular traps in homeostasis and disease DOI Creative Commons

Han Wang,

Susan J. Kim,

Lei Yu

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Sept. 20, 2024

Language: Английский

Citations

29
How macrophage heterogeneity affects tuberculosis disease and therapy DOI
David G. Russell, Nelson V. Simwela,

Joshua T. Mattila

et al.

Nature reviews. Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Language: Английский

Citations

4
Metabolically active neutrophils represent a permissive niche for Mycobacterium tuberculosis DOI
J. Tucker Andrews, Zijing Zhang, Gauri Prasad

et al.

Mucosal Immunology, Journal Year: 2024, Volume and Issue: 17(5), P. 825 - 842

Published: June 5, 2024

Language: Английский

Citations

15
The role of plasmacytoid dendritic cells (pDCs) in immunity during viral infections and beyond DOI Creative Commons

Clémence Ngo,

Clémence Garrec,

Elena Tomasello

et al.

Cellular and Molecular Immunology, Journal Year: 2024, Volume and Issue: 21(9), P. 1008 - 1035

Published: May 22, 2024

Abstract Type I and III interferons (IFNs) are essential for antiviral immunity act through two different but complimentary pathways. First, IFNs activate intracellular antimicrobial programs by triggering the upregulation of a broad repertoire viral restriction factors. Second, innate adaptive immunity. Dysregulation IFN production can lead to severe immune system dysfunction. It is thus crucial identify characterize cellular sources IFNs, their effects, regulation promote beneficial effects limit detrimental which depend on nature infected or diseased tissues, as we will discuss. Plasmacytoid dendritic cells (pDCs) produce large amounts all subtypes during infection. pDCs resistant infection many viruses, inhibiting evasion mechanisms viruses that target downstream responses. Therefore, considered control infections establishment protective A thorough bibliographical survey showed that, in most infections, despite being major producers, actually dispensable host resistance, achieved multiple depending tissue. Moreover, primary responses only transiently affected absence pDCs. More surprisingly, be some autoimmune diseases. This makes conservation vertebrate evolution an enigma raises outstanding questions about role not also other diseases under physiological conditions.

Language: Английский

Citations

13
Metabolic diseases and interferon immune responses DOI Creative Commons
Haiyan Zhou, Chunyan Liu, Yuerong Zhang

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Abstract Metabolic diseases, including obesity, diabetes, and metabolic‐associated fatty liver disease (MAFLD), are increasingly common worldwide, posing a significant public health challenge. Recent research has revealed complex interplay between these metabolic disorders interferon (IFN) immune responses. As key regulators, interferons coordinate the host's defense against viral infections essential for maintaining homeostasis. However, dysregulation can significantly disrupt IFN signaling pathways, affecting intensity efficiency of Conversely, alterations in influence onset progression diseases. This review explores mechanisms by which diseases modulate responses, focusing on how MAFLD alter signaling. Additionally, we examine implications changes responses By synthesizing current research, this aims to elucidate offering insights future clinical applications field IFN‐related

Language: Английский

Citations

1
Sterile production of interferons in the thymus affects T cell repertoire selection DOI
K. Maude Ashby, Matouš Vobořil, Oscar Camilo Salgado

et al.

Science Immunology, Journal Year: 2024, Volume and Issue: 9(97)

Published: July 26, 2024

Type I and III interferons (IFNs) are robustly induced during infections protect cells against viral infection. Both type IFNs also produced at low levels in the thymus steady state; however, their role T cell development immune tolerance is unclear. Here, we found that both were constitutively by a very small number of AIRE + murine thymic epithelial cells, independent microbial stimulation. Antigen-presenting highly responsive to IFNs, required for activation maturation 1 conventional dendritic macrophages, B cells. Loss IFN sensing led reduced regulatory selection, receptor (TCR) repertoire diversity, enhanced autoreactive responses self-antigens expressed peripheral signaling. Thus, constitutive exposure generating tolerant diverse TCR repertoire.

Language: Английский

Citations

7
Ontogeny and Function of Plasmacytoid Dendritic Cells DOI
Nicholas M. Adams, Annesa Das, Tae Jin Yun

et al.

Annual Review of Immunology, Journal Year: 2024, Volume and Issue: 42(1), P. 347 - 373

Published: June 28, 2024

Plasmacytoid dendritic cells (pDCs) represent a unique cell type within the innate immune system. Their defining property is recognition of pathogen-derived nucleic acids through endosomal Toll-like receptors and ensuing production I interferon other soluble mediators, which orchestrate adaptive responses. We review several aspects pDC biology that have recently come to fore. discuss emerging questions regarding lineage affiliation origin pDCs argue these constitute an integral part lineage. emphasize specific function as sentinels virus infection, particularly their distinct response virus-infected cells. This essential evolutionary role has been important for control coronaviruses, demonstrated by recent COVID-19 pandemic. Finally, we highlight key contribution systemic lupus erythematosus, in therapeutic targeting currently underway.

Language: Английский

Citations

6
CD4-mediated immunity shapes neutrophil-driven tuberculous pathology DOI Creative Commons
Benjamin H. Gern,

Josepha M Klas,

Kimberly A. Foster

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 16, 2024

Summary Pulmonary Mycobacterium tuberculosis (Mtb) infection results in highly heterogeneous lesions ranging from granulomas with central necrosis to those primarily comprised of alveolitis. While alveolitis has been associated prior immunity human post-mortem studies, the drivers these distinct pathologic outcomes are poorly understood. Here, we show that divergent lesion structures can be modeled C3HeB/FeJ mice and regulated by immunity. Using quantitative imaging, scRNAseq, flow cytometry, demonstrate Mtb absence elicits dysregulated neutrophil recruitment necrotic granulomas. In contrast, induces rapid activation T cells, local macrophage activation, diminished late responses. Depletion studies at stages demonstrated neutrophils required for early initiation propagation chronic stages, whereas CD4 cell responses prevent feedforward circuits necrosis. Together, reveal fundamental determinants structure pathogenesis, which have important implications new strategies or treat tuberculosis.

Language: Английский

Citations

5
Burden of Tuberculosis in Western Sudan During the Sudan Armed Conflict DOI Open Access

Amal Khalil Yousif Mohammed,

Eldisugi Hassan Mohammed Humida,

Abdullahi Abubakar Ali

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 5, 2025

Tuberculosis remains the leading cause of death from infectious diseases worldwide. This study assesses impact tuberculosis in western Sudan during armed conflict 2023-2024. was conducted by respiratory department El-Obeid Teaching Hospital North Kordofan State, Sudan. The encompassed 751 patients with tuberculosis. Data were collected August 2024. A data collection sheet developed to compile all pertinent information. Of patients, 659 (87.7%) classified as new cases, 85 (11.3%) recurrent and seven (9.3%) multidrug-resistant (MDR). 470 (86.2%) male 206 (91.7%) female. majority aged 26-35 years 166 (22.1%), followed those 19-25 at 160 (21.3%) 36-45 127 (16.9%), totaling individuals. incidence rate rose markedly 54 per 100,000 63 people. During wartime, there an increase disease, non-compliance treatment methods, multidrug resistance. demographics most affected include men, laborers, individuals employed gold mining. Extrapulmonary is increasingly detected lymph nodes, pleura, abdominal areas. Immediate enhancements healthcare system are necessary prevent widespread transmission

Language: Английский

Citations

0
Evaluation of the cross-immunity between Mycobacterium tuberculosis and Mycobacterium abscessus in vitro DOI Creative Commons
Da Xu,

Yujie Gu,

Guilian Li

et al.

BMC Microbiology, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 9, 2025

Language: Английский

Citations

0