The Role of the Dorsolateral Prefrontal Cortex in Ego Dissolution and Emotional Arousal During the Psychedelic State DOI Creative Commons

Clayton R. Coleman,

Kenneth Shinozuka, Robert Tromm

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 15, 2024

Abstract Lysergic acid diethylamide (LSD) is a classic serotonergic psychedelic that induces profoundly altered conscious state. In conjunction with psychological support, it currently being explored as treatment for generalized anxiety disorder and depression. The dorsolateral prefrontal cortex (DLPFC) brain region known to be involved in mood regulation disorders; hypofunction the left DLPFC associated This study investigated role of psycho-emotional effects LSD functional magnetic resonance imaging (fMRI) magnetoencephalography (MEG) data healthy human participants during acute experience. fMRI data, we measured correlation between changes resting-state connectivity (RSFC) post-scan subjective ratings positive mood, emotional arousal, ego dissolution. We found significant, correlations dissolution & right DLPFC, thalamus, higher-order visual area, fusiform face area (FFA). Additionally, arousal was significantly increased intraparietal sulcus (IPS), salience network (SN). A confirmational “reverse” analysis, which outputs original RSFC analysis were used input seeds, substantiated aforementioned regions both arousal. Subsequently, on directed MEG source-localized output reverse analyses. Granger causality (GC) revealed information flow two nodes ‘ego network’, thalamus theta band, substantiating hypothesis disruptions thalamic gating underlie experience Overall, this multimodal elucidates LSD-induced states consciousness sheds more light basis

Language: Английский

Exploring Cortical Interneurons in Substance Use Disorder: From Mechanisms to Therapeutic Perspectives DOI Creative Commons
Sai Shi, Tianzhen Chen, Hang Su

et al.

The Neuroscientist, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Interneurons (INs) play a crucial role in the regulation of neural activity within medial prefrontal cortex (mPFC), brain region critically involved executive functions and behavioral control. In recent preclinical studies, dysregulation INs mPFC has been implicated pathophysiology substance use disorder, characterized by vulnerability to chronic drug use. Here, we explore diversity their connectivity roles addiction. We also discuss how these change over time with exposure. Finally, focus on noninvasive stimulation as therapeutic approach for targeting highlighting its potential restore circuits.

Language: Английский

Citations

0
The Role of the Dorsolateral Prefrontal Cortex in Ego Dissolution and Emotional Arousal During the Psychedelic State DOI Creative Commons

Clayton R. Coleman,

Kenneth Shinozuka, Robert Tromm

et al.

Human Brain Mapping, Journal Year: 2025, Volume and Issue: 46(5)

Published: April 1, 2025

ABSTRACT Lysergic acid diethylamide (LSD) is a classic serotonergic psychedelic that induces profoundly altered conscious state. In conjunction with psychological support, it currently being explored as treatment for generalized anxiety disorder and depression. The dorsolateral prefrontal cortex (DLPFC) brain region known to be involved in mood regulation disorders; hypofunction the left DLPFC associated This study investigated role of psycho‐emotional effects LSD functional magnetic resonance imaging (fMRI) magnetoencephalography (MEG) data healthy human participants during acute experience. fMRI data, we measured correlation between changes resting‐state connectivity (RSFC) post‐scan subjective ratings positive mood, emotional arousal, ego dissolution. We found significant, correlations dissolution & right DLPFC, thalamus, higher‐order visual area, fusiform face area (FFA). Additionally, arousal was significantly increased intraparietal sulcus (IPS), salience network (SN). A confirmational “reverse” analysis, which outputs original RSFC analysis were used input seeds, substantiated aforementioned regions both arousal. Subsequently, on directed MEG source‐localized output reverse analyses. Granger causality (GC) revealed information flow two nodes ‘ego network’, thalamus theta band, substantiating hypothesis disruptions thalamic gating underlie experience Overall, this multimodal elucidates LSD‐induced states consciousness sheds more light basis

Language: Английский

Citations

0
Alternating bilateral sensory stimulation alleviates alcohol-induced conditioned place preference via a superior colliculus-VTA circuit DOI Creative Commons
Jie Lei, Pei Zhang, Tongxia Li

et al.

Cell Reports, Journal Year: 2024, Volume and Issue: 43(7), P. 114383 - 114383

Published: June 25, 2024

Alcohol is the most widely used addictive substance, potentially leading to brain damage and genetic abnormalities. Despite its prevalence associated risks, current treatments have yet identify effective methods for reducing cravings preventing relapse. In this study, we find that 4-Hz alternating bilateral sensory stimulation (ABS) effectively reduces ethanol-induced conditioned place preference (CPP) in male mice, while flash light does not exhibit therapeutic effects. Whole-brain c-Fos mapping demonstrates ABS triggers notable activation superior colliculus GABAergic neurons (SC

Language: Английский

Citations

2
Deciphering brain cellular and behavioral mechanisms: Insights from single‐cell and spatial RNA sequencing DOI
Renrui Chen, Pengxing Nie, Jing Wang

et al.

Wiley Interdisciplinary Reviews - RNA, Journal Year: 2024, Volume and Issue: 15(4)

Published: July 1, 2024

The brain is a complex computing system composed of multitude interacting neurons. computational outputs this determine the behavior and perception every individual. Each cell expresses thousands genes that dictate cell's function physiological properties. Therefore, deciphering molecular expression each great significance for understanding its characteristics role in function. Additionally, positional information can provide crucial insights into their involvement local circuits. In review, we briefly overview principles single-cell RNA sequencing spatial transcriptomics, potential issues challenges data processing, applications research. We further outline several promising directions neuroscience could be integrated with sequencing, including neurodevelopment, identification novel microstructures, cognition behavior, neuronal positioning, molecules cells related to advanced functions, sleep-wake cycles/circadian rhythms, modeling believe deep integration these contribute significantly roles individual or types specific thereby making important contributions addressing critical questions those fields. This article categorized under: Evolution Genomics > Computational Analyses Disease Development Disease.

Language: Английский

Citations

1
Multi-regional control of amygdalar dynamics reliably reflects fear memory age DOI Creative Commons
Yuichi Makino, Yi Wang, Thomas J. McHugh

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 9, 2024

The basolateral amygdala (BLA) is crucial for the encoding and expression of fear memory, yet it remains unexplored how neural activity in this region dynamically influenced by distributed circuits across brain to facilitate memory different ages. Using longitudinal multisite electrophysiological recordings male mice, we find that recall older contextual accompanied weaker, more rhythmic, BLA gamma which distally entrained theta oscillations both hippocampal CA1 anterior cingulate cortex. Computational modeling with Light Gradient Boosting Machine using extracted oscillatory features from these three regions, as well Transformer raw local field potentials, accurately classified remote recent primarily based on theta. These results demonstrate a non-biased manner multi-regional control serves reliable signatures age-dependent mechanisms.

Language: Английский

Citations

0
The Role of the Dorsolateral Prefrontal Cortex in Ego Dissolution and Emotional Arousal During the Psychedelic State DOI Creative Commons

Clayton R. Coleman,

Kenneth Shinozuka, Robert Tromm

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 15, 2024

Abstract Lysergic acid diethylamide (LSD) is a classic serotonergic psychedelic that induces profoundly altered conscious state. In conjunction with psychological support, it currently being explored as treatment for generalized anxiety disorder and depression. The dorsolateral prefrontal cortex (DLPFC) brain region known to be involved in mood regulation disorders; hypofunction the left DLPFC associated This study investigated role of psycho-emotional effects LSD functional magnetic resonance imaging (fMRI) magnetoencephalography (MEG) data healthy human participants during acute experience. fMRI data, we measured correlation between changes resting-state connectivity (RSFC) post-scan subjective ratings positive mood, emotional arousal, ego dissolution. We found significant, correlations dissolution & right DLPFC, thalamus, higher-order visual area, fusiform face area (FFA). Additionally, arousal was significantly increased intraparietal sulcus (IPS), salience network (SN). A confirmational “reverse” analysis, which outputs original RSFC analysis were used input seeds, substantiated aforementioned regions both arousal. Subsequently, on directed MEG source-localized output reverse analyses. Granger causality (GC) revealed information flow two nodes ‘ego network’, thalamus theta band, substantiating hypothesis disruptions thalamic gating underlie experience Overall, this multimodal elucidates LSD-induced states consciousness sheds more light basis

Language: Английский

Citations

0