Oncogenic functions and therapeutic potentials of targeted inhibition of SMARCAL1 in small cell lung cancer DOI
Beibei Sun, Guizhen Wang,

Si-Chong Han

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 592, P. 216929 - 216929

Published: April 30, 2024

Language: Английский

ER-tethering directs TREX1 penetration of a BAF-dependent barrier at micronuclei DOI
Yanyang Chen, Eléonore Toufektchan, Xiaohan Luan

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

SUMMARY Micronuclei are membrane-encapsulated nuclear aberrations that form following chromosome segregation errors. Micronuclear membrane collapse permits access of the pattern recognition receptor cGAS and its antagonist, TREX1 exonuclease. carboxy-terminal domain mediated endoplasmic reticulum tethering association is essential for invasion into ruptured micronuclei, however mechanisms underlying this dependency unknown. Here, we identify barrier-to-autointegration assembly factor 1 (BAF) as a key regulator activity at micronuclei. BAF accumulates on micronuclei augments recruitment in manner depends interactions with membrane-associated LEM-domain proteins. Despite delayed entry, exhibits enhanced micronuclear DNA degradation independence from ER-tethering BAF-deficient cells. In accordance, recombinant protein inhibits TREX1-mediated vitro DNA-binding. similarly outcompetes interaction reduces activation These findings reveal, BAF-dependent protective barrier to diffusive entry binding proteins explaining requirement localization suppression productive substrate activate innate immune responses chromosomally unstable

Language: Английский

Citations

0
Immune checkpoint inhibitors: From friend to foe DOI Creative Commons
Prem Rajak

Toxicology Reports, Journal Year: 2025, Volume and Issue: 14, P. 102033 - 102033

Published: April 24, 2025

Language: Английский

Citations

0
HLTF resolves G4s and promotes G4-induced replication fork slowing to maintain genome stability DOI
Gongshi Bai, Theresa Endres, Ulrike Kühbacher

et al.

Molecular Cell, Journal Year: 2024, Volume and Issue: 84(16), P. 3044 - 3060.e11

Published: Aug. 1, 2024

Language: Английский

Citations

3
cGAS/STING in skin melanoma: from molecular mechanisms to therapeutics DOI Creative Commons

Jafaridarabjerdi Mahin,

Xuezhu Xu, Ling Li

et al.

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: Nov. 18, 2024

Language: Английский

Citations

3
Oncogenic functions and therapeutic potentials of targeted inhibition of SMARCAL1 in small cell lung cancer DOI
Beibei Sun, Guizhen Wang,

Si-Chong Han

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 592, P. 216929 - 216929

Published: April 30, 2024

Language: Английский

Citations

2