Metabolic Dialogue Shapes Immune Response in the Tumor Microenvironment DOI Creative Commons

Fengxia Gao,

Rushil Shah, Gang Xin

et al.

European Journal of Immunology, Journal Year: 2025, Volume and Issue: 55(4)

Published: April 1, 2025

ABSTRACT The fate of immune cells is fundamentally linked to their metabolic program, which also influenced by the landscape environment. tumor microenvironment represents a unique system for intercellular interactions, where tumor‐derived metabolites suppress effector CD8 + T and promote tumor‐promoting macrophages, reinforcing an immune‐suppressive niche. This review will discuss recent advancements in metabolism research, exploring interplay between various effects on within microenvironment.

Language: Английский

Digestive cancers: mechanisms, therapeutics and management DOI Creative Commons
Tianzuo Zhan, Johannes Betge, Nadine Schulte

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: Jan. 14, 2025

Abstract Cancers of the digestive system are major contributors to global cancer-associated morbidity and mortality, accounting for 35% annual cases cancer deaths. The etiologies, molecular features, therapeutic management these entities highly heterogeneous complex. Over last decade, genomic functional studies have provided unprecedented insights into biology cancers, identifying genetic drivers tumor progression key interaction points cells with immune system. This knowledge is continuously translated novel treatment concepts targets, which dynamically reshaping landscape tumors. In this review, we provide a concise overview etiology pathology six most common cancers system, including esophageal, gastric, biliary tract, pancreatic, hepatocellular, colorectal cancers. We comprehensively describe current stage-dependent pharmacological malignancies, chemo-, targeted, immunotherapy. For each entity, an recent advancements research progress. Finally, how heterogeneity evasion deepen our understanding therapy resistance outlook on innovative strategies that will shape future CAR-T cell therapy, antibody-drug conjugates targeted therapies.

Language: Английский

Citations

2
Unraveling UPR-Mediated Intercellular Crosstalk: Implications for Immunotherapy Resistance Mechanisms DOI
Lu Si, Qimin Zhou, Rongjie Zhao

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217613 - 217613

Published: March 1, 2025

Language: Английский

Citations

2
Taurine prevents mitochondrial dysfunction and protects mitochondria from reactive oxygen species and deuterium toxicity DOI Creative Commons
Stephanie Seneff, Anthony M. Kyriakopoulos

Amino Acids, Journal Year: 2025, Volume and Issue: 57(1)

Published: Jan. 10, 2025

Abstract Taurine, although not a coding amino acid, is the most common free acid in body. Taurine has multiple and complex functions protecting mitochondria against oxidative-nitrosative stress. In this comprehensive review paper, we introduce novel potential role for taurine from deuterium (heavy hydrogen) toxicity. This can be of crucial impact to either normal or cancer cells that have highly different mitochondrial redox status. Deuterium an isotope hydrogen with neutron as well proton, making it about twice heavy hydrogen. We first explain important gut microbiome sulfomucin barrier play management. describe synergistic effects protect deleterious accumulation mitochondria, which disrupts ATP synthesis by ATPase pumps. Moreover, taurine’s derivatives, N-chlorotaurine (NCT) N-bromotaurine (NBrT), produced through spontaneous reaction hypochlorite hypobromite, fascinating regulatory roles oxidative stress beyond. how could potentially alleviate stress, primarily metabolic collaboration among various microflora produce depleted nutrients water, way leaky barrier, inflammatory bowel disease, colon cancer.

Language: Английский

Citations

1
Advancements in immunotherapy for gastric cancer: Unveiling the potential of immune checkpoint inhibitors and emerging strategies DOI

Jiawei Song,

Jun Zhu,

Yu Jiang

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: 1880(2), P. 189277 - 189277

Published: Feb. 10, 2025

Language: Английский

Citations

1
Comprehensive metabolomic analysis identifies key biomarkers and modulators of immunotherapy response in NSCLC patients DOI
Se‐Hoon Lee, Sujeong Kim, Ju‐Eun Lee

et al.

Drug Resistance Updates, Journal Year: 2024, Volume and Issue: 77, P. 101159 - 101159

Published: Oct. 10, 2024

Language: Английский

Citations

5
Tumor Microenvironment: Nurturing Cancer Cells for Immunoevasion and Druggable Vulnerabilities for Cancer Immunotherapy DOI
Hongyang Yu, Jinyang Li, Shiyin Peng

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 611, P. 217385 - 217385

Published: Dec. 6, 2024

Language: Английский

Citations

5
SLC6A6 alleviates cellular senescence in glioblastoma via the CSK/AKT/FoxO1 signaling DOI Creative Commons
Li Wei, Xianyou Xia, Ting Wang

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Abstract ・Background: Malignant glioblastoma exhibits cellular senescence characterized by changing tumor microenvironment. Solute carrier family 6 member (SLC6A6), a multichannel transmembrane protein, plays crucial role in regulating cell proliferation, apoptosis, differentiation and However, the molecular mechanism of SLC6A6 remains unknown. Our study aimed to elucidate regulatory mechanisms proliferation cells. ・Methods: Expression was examined samples from 50 patients with glioblastoma, associations between expression survival outcome were evaluated using Kaplan–Meier Cox regression analyses. To investigate SLC6A6, we used short hairpin RNA (shRNA) overexpression vector construct SLC6A6-knockdown -overexpression cells, respectively. The confirmed vitro an orthotopic mouse model. ・Results: Patients high had worse prognosis. Downregulation protein inhibited malignant phenotypes cells vitro. In addition, affected directly binding CSK its N-terminal cytoplasmic domain, thereby enhancing AKT phosphorylation. Furthermore, knockdown growth shortened xenograft ・Conclusion: SLC6A6 can promote progression inhibit affecting CSK/AKT/FoxO1 signaling pathway. might be valuable biomarker treatment glioblastoma.

Language: Английский

Citations

0
Integrative analysis of ferroptosis in the hypoxic microenvironment of gastric cancer unveils the immune landscape and personalized therapeutic strategies DOI Creative Commons

Xiao Xu,

Luzhong Fa,

Xiaoxiao Sun

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 14

Published: Jan. 13, 2025

Background Ferroptosis is a cell death mode caused by excessive accumulation of lipid peroxides disturbance intracellular metabolic pathway, which closely related to iron and cholesterol metabolism homeostasis. Its regulation within the hypoxic tumor microenvironment (TME) has potential improve effectiveness immunotherapy. The predictive role ferroptosis in gastric cancer (GC) hypoxia TME, particularly relation TME immune infiltration, not been fully explained. Methods By analyzing mRNA expression data hypoxia-related genes, prediction model was constructed evaluate further value clinical characteristics, immunotherapy efficacy cancer, essential genes were validated. Results Two distinct molecular states ferroptosis-hypoxia identified GC. Notably, patients with high risk scores (FHRS) displayed significant levels epithelial-mesenchymal transition (EMT), associated unfavorable prognosis, increased chemoresistance, heightened immunosuppression. Conclusions This study demonstrates that under conditions significantly affects modulation microenvironment. FHRS can independently predict prognosis cancer. Assessing status individual will help selecting more suitable regimens providing better understanding characteristics predicting immunotherapeutic outcomes.

Language: Английский

Citations

0
Transport and inhibition mechanism for human TauT-mediated taurine uptake DOI
Yulin Chao, Zixuan Zhou, Hao Xia

et al.

Cell Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Language: Английский

Citations

0
Single-cell profiling of SLC family transporters: uncovering the role of SLC7A1 in osteosarcoma DOI Creative Commons

Yan Liao,

Junkai Chen, Hao Yao

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 22, 2025

Osteosarcoma is the most common malignant bone tumor in children and adolescents, characterized by high disability mortality rates. Over past three decades, therapeutic outcomes have plateaued, underscoring critical need for innovative targets. Solute carrier (SLC) family transporters been implicated progression of a variety tumors, however, their specific role osteosarcoma remains poorly understood. The single-cell sequencing data from GSE152048 GSE162454, along with RNA-seq TARGET GSE21257 cohorts, were utilized analysis this study. LASSO regression was conducted to identify prognostic genes construct an SLC-related signature. Survival ROC evaluated validity ESTIMATE CIBERSORT Packages assess immune infiltration status. Pseudotime CellChat analyses performed investigate relationship between SLC7A1, phenotypes, microenvironment. CCK8 assays, EdU staining, colony formation Transwell co-culture systems used effects SLC7A1 on cell proliferation, metastasis, macrophage polarization. Finally, virtual docking identified potential drugs targeting SLC7A1. SLCs displayed distinct expression patterns across various types within microenvironment, myeloid cells exhibiting preference amino acid uptake. A model comprising nine constructed via regression, showing highest hazard ratio. Multiple analytical algorithms indicated that associated checkpoint gene expression. Single-cell predominantly expressed correlated characteristics. also regulate interactions macrophages, as well modulate function through multiple pathways. In vitro assays survival demonstrated inhibition suppressed phenotype cells, correlating poor prognosis. Co-culture models confirmed involvement screening CETSA Cepharanthine inhibitors signatures can be evaluation osteosarcoma. Pharmacological may feasible approach

Language: Английский

Citations

0