Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)
Published: April 16, 2025
Language: Английский
APOPTOSIS, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 20, 2025
Language: Английский
Citations
0
Journal of Virology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 20, 2025
ABSTRACT Zika virus (ZIKV) is associated with microcephaly in neonates and neurological disorders adults. Chronic ZIKV infection has been identified the testes, indicating that can lead to prolonged illness, yet its pathogenesis remains poorly understood. Here, we found does not induce significant cell death mouse macrophages despite critical role plays antiviral immune response. Furthermore, discovered impairs activation of NLPR3-dependent inflammasome inhibits apoptosis. Consequently, investigated regulatory mechanism NLRP3 apoptosis context infection. Our results revealed reductions protein expression levels A20, attributable post-transcriptional or translational effects during These findings suggest may disrupt pathways, leading pathogenicity. IMPORTANCE (ZIKV), first isolated from a nonhuman primate Africa 1947, was relatively understudied until 2016. By then, had already reported more than 20 countries territories. The poses risk, as it infants adults; however, underlying mechanisms responsible for these severe outcomes remain unclear. In this study, demonstrate significantly reduces A20 proteins through processes, which leads inhibited death. are because vital host's highlight how compromises essential raising serious concerns about pathogenesis. A comprehensive understanding disruption developing targeted interventions mitigate virus' impact on public health.
Language: Английский
Citations
0
APOPTOSIS, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 20, 2025
Language: Английский
Citations
0
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2025, Volume and Issue: unknown, P. 167782 - 167782
Published: March 1, 2025
Language: Английский
Citations
0
Cell Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown
Published: March 8, 2025
Language: Английский
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0
Aging and Disease, Journal Year: 2025, Volume and Issue: unknown, P. 0 - 0
Published: Jan. 1, 2025
The aging immune system presents profound challenges, notably through the decline of T cell function, which is critical for effective responses. As age-related changes lead to diminished diversity and heighten immunosuppressive environments, older individuals face increased susceptibility infections, autoimmune diseases, reduced efficacy immunotherapies. This review investigates intricate mechanisms by drives immunosenescence, including suppression, evasion, antigen reactivity, overexpression checkpoint molecules. By delving into innovative therapeutic strategies aimed at rejuvenating populations modifying immunological landscape, we highlight potential enhancing resilience in elderly. Ultimately, our goal outline actionable pathways restoring thereby improving health outcomes facing decline.
Language: Английский
Citations
0
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16
Published: March 21, 2025
There has been abundant research on the variety of programmed cell death pathways. Apoptosis, pyroptosis, and necroptosis under action caspase family are essential for innate immune response. Caspases classified into inflammatory caspase-1/4/5/11, apoptotic caspase-3/6/7, caspase-2/8/9/10. Although is not caspase-dependent to transmit signals, it can cross-link with pyroptosis apoptosis signals regulation caspase-8. An increasing number studies have reiterated involvement in acute lung injuries caused by bacterial viral infections, blood transfusion, ventilation, which influenced noxious stimuli that activate or inhibit engagement pathways, leading subsequent injury. This article reviews role caspases implicated diverse mechanisms injury status relevant inhibitors against target proteins described mechanisms. The findings this review may help delineating novel therapeutic targets
Language: Английский
Citations
0
Liver International, Journal Year: 2025, Volume and Issue: 45(4)
Published: March 21, 2025
PANoptosis is a multimodal form of cell death that involves inflammatory, apoptotic, and necroptotic pathways, playing key role in the development liver diseases. This article first outlines definition characteristics PANoptosis, then explores its mechanisms action different types diseases, including acute injury, failure, metabolic dysfunction-associated fatty disease, hepatocellular carcinoma. Furthermore, this analyses molecular regulatory network potential therapeutic targets. Finally, summarises current research on diseases future directions, it reviews emerging mechanism
Language: Английский
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Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(03), P. 2490 - 2504
Published: Jan. 1, 2025
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: March 28, 2025
Sepsis is defined as a condition related to infection that manifests with multiorgan dysfunction, representing life-threatening state. Consequently, severe complications frequently occur, liver injury being one of the most prevalent serious sepsis. Liver dysfunction during sepsis serves an independent predictor mortality. This review provides comprehensive overview current research on sepsis-induced (SILI), encompassing clinical manifestations, diagnostic criteria, pathogenesis and therapeutic strategies associated this condition. SILI may manifest hypoxic hepatitis due ischemia shock, cholestasis resulting from abnormal bile metabolism, or duct sclerosis. The pathophysiology involves intricate interactions among inflammatory response, oxidative stress, cell death. All these factors complicate treatment represent potential targets for intervention. Furthermore, addresses limitations inherent in conventional therapies currently employed managing emphasizes novel targeted aimed at addressing fundamental mechanisms underlying
Language: Английский
Citations
0