Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 159080 - 159080
Published: Dec. 1, 2024
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1094 - 1094
Published: Jan. 27, 2025
Type 2 diabetes mellitus (T2DM), a prevalent chronic disease affecting over 400 million people globally, is driven by genetic and environmental factors. The pathogenesis involves insulin resistance β-cell dysfunction, mediated mechanisms such as the dedifferentiation of β-cells, mitochondrial oxidative stress. Treatment should be based on non-pharmacological therapy. Strategies increased physical activity, dietary modifications, cognitive-behavioral therapy are important in maintaining normal glycemia. Advanced therapies, including SGLT2 inhibitors GLP-1 receptor agonists, complement these treatments offer solid glycemic control, weight reduced cardiovascular risk. Complications T2DM, diabetic kidney disease, retinopathy, neuropathy, underscore need for early diagnosis comprehensive management to improve patient outcomes quality life.
Language: Английский
Citations
4
Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)
Published: Nov. 15, 2024
Abstract Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have a reliable hypoglycaemic and weight-loss effect that can intervene in obesity, which is the basis of type 2 diabetes pathology. GLP-1RA therapy has shown potential benefits reducing risk major adverse cardiovascular events improving kidney outcomes patients with at high for disease. More recent evidence expanding their to heart failure preserved ejection fraction clinically important renal without diabetes. Some sub-analyses large clinical trials suggest sodium-glucose cotransporter inhibitor combination may provide more significant reductions hospitalization composite than each alone. Moreover, addition finerenone this could potentially stronger cardiorenal protective benefits. Further studies are needed assess determine suitable patient population therapy. Graphical abstract Suspected impacts GLP-1RAs, SGLT2is, oncardiovascular outcomes. CV, cardiovascular; GLP-1RA, glucagon-like agonist; HFpEF, fraction; HFrEF, reduced MI, myocardial infarction; SGLT2i, inhibitor.
Language: Английский
Citations
7
Tissue and Cell, Journal Year: 2024, Volume and Issue: 91, P. 102590 - 102590
Published: Oct. 21, 2024
Language: Английский
Citations
5
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Jan. 4, 2025
Abstract While recent studies have indicated a potential link between incense burning and respiratory diseases, there is lack of data specifically focused on diabetic patients. To explore the relationship indoor impaired lung function among Chinese individuals with diabetes, comprehensive cross-sectional study was undertaken, enrolling 431 adults diagnosed diabetes. Information characteristics collected using structured questionnaire. The outcome study, function, assessed spirometry. Multivariable logistic regression models were employed. In fully adjusted model, participants exposed to exhibited 130% higher odds compared those not exposed, as by an ratio (OR) 2.3 (95% confidence interval [CI]: 0.97, 5.16; P = 0.05). Notably, this association statistically significant only in men (OR 3.39; 95%CI: 1.07, 9.82; 0.03). Our has elucidated exposure independently demographic factors. These findings underscore importance considering environmental factors, such burning, management care individuals.
Language: Английский
Citations
0
Oncology Letters, Journal Year: 2025, Volume and Issue: 29(3)
Published: Jan. 8, 2025
The relationship between diabetes and pancreatic cancer is well documented; however, the effect of preoperative blood glucose levels on prognosis postoperative complications currently unclear. present study aimed to investigate overall survival (OS) in patients with cancer. This retrospective included 225 treated at Fourth Hospital Hebei Medical University from January 2015 December 2020. Patients were grouped based (normal, ≤6.11 mmol/l; high, >6.11 mmol/l). Data demographics, clinical history, tumor characteristics, treatment laboratory results collected. High associated reduced OS time [hazard ratio (HR), 1.68; 95% confidence interval (CI), 1.15-2.45; P=0.007] increased (29.2 vs. 9.8%; χ2=13.658; P<0.001). Median was significantly shorter high group (14.2 20.5 months; HR, 1.96; CI, 1.38-2.77; Elevated CA19-9 also a predictor poor (HR, 1.70; 1.06-2.74; P=0.029). elevated independent predictors finding suggests that have greater impact compared history diabetes. poorer higher incidence those lower levels, underscoring importance management. Effective control may improve outcomes
Language: Английский
Citations
0
Medicina, Journal Year: 2025, Volume and Issue: 61(2), P. 225 - 225
Published: Jan. 27, 2025
Background and Objectives: Urinary tract infection (UTI) is a common comorbidity in diabetic patients, making up one of the causes sepsis. This study aims to develop nomogram predict risk probability sepsis patients with UTI (DPUTIs). Materials Methods: retrospective observational study. Clinical data for DPUTIs were extracted from Medical Information Mart Intensive Care IV database. Eligible randomly divided into training validation cohorts 7:3 ratio. Independent prognostic factors determined using least absolute shrinkage selection operator (LASSO) regression multivariate logistic regression. A corresponding based on these was constructed occurrence DPUTIs. The discrimination assessed by multiple indicators, including area under receiver operating characteristic curve (AUC), net reclassification improvement index (NRI), integrated (IDI). In addition, calibration decision analysis (DCA) used evaluate performance nomogram. Results: total 1990 included. Nine independent identified as predictive included urine red blood cell classification (urine RBC cat), white WBC glucose, age, temperature, cells (WBCs), sequential organ failure assessment (SOFA) score, lymphocytes, hematocrit. AUC, NRI, IDI indicated robust discrimination. Hosmer–Lemeshow test showed good DCA demonstrated better clinical utility Conclusions: established this helps clinicians DPUTIs, providing evidence optimizing management related factors.
Language: Английский
Citations
0
Published: Jan. 1, 2025
Language: Английский
Citations
0
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16
Published: Jan. 30, 2025
Lipid metabolism plays a crucial role in maintaining homeostasis and overall health, as lipids are essential molecules involved bioenergetic processes. An increasing body of research indicates that disorders lipid can contribute to the development progression various diseases, including hyperlipidemia, obesity, non-alcoholic fatty liver disease (NAFLD), diabetes mellitus, atherosclerosis, cancer, potentially leading poor prognoses. The activation oxidative stress pathway disrupts induces cellular stress, significantly contributing metabolic disorders. A well-documented crosstalk interconnection between these exists. Consequently, researchers have sought identify antioxidant-rich substances readily accessible everyday foods for potential use complementary therapies. Curcumin, known its anti-inflammatory antioxidant properties, has been shown enhance activity, mitigate alleviate by reducing reactive oxygen species (ROS) accumulation. These effects include decreasing fat deposition, acid uptake, improving insulin sensitivity. review existing literature reveals numerous studies emphasizing curcumin prevention management diseases. Curcumin influences through multiple mechanisms action, with playing central Thus, we aimed elucidate unified mechanism offering new insights into treatment Firstly, this article provides brief overview basic pathophysiological processes metabolism, well pathogenesis Notably, reviews mitigating preventing treating diseases associated disorders, diabetes, thereby highlighting therapeutic metabolism-related
Language: Английский
Citations
0
Nano Trends, Journal Year: 2025, Volume and Issue: 9, P. 100085 - 100085
Published: Jan. 31, 2025
Language: Английский
Citations
0
ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 14, 2025
Implantable pancreatic β cell-encapsulated devices are required for the treatment of type 1 diabetes. Such should enable a semipermeable membrane to release insulin in response glucose levels while avoiding immune reactions. Micrometer-thick track-etched porous polycarbonate (PC) membranes have been used this purpose. However, immediate remains challenge development such membranes. Herein, we attempted develop freestanding polymeric ultrathin film (nanosheet) with structure that can be device. Specifically, fabricated nonbiodegradable, PC nanosheet enhance molecular permeability. The was multistacked ensure controlled permeability proteins various weights, as and IgG. prepared by gravure coating using blend solution comprising polystyrene (PS) induce macro-phase separation PS. When PC:PS weight ratio mixture reduced 3:1, succeeded fabricating (thickness: 100 nm, diameter: < 2.5 μm). A triple layer nanosheets pore sizes demonstrated 10 times less protein clogging, higher permeability, comparable IgG-blocking capability compared commercially available Finally, device equipped multilayered permeable preserved level insulin-producing cells before, during, after cell-encapsulation process. We believe will changes levels.
Language: Английский
Citations
0