Sex differences in central amygdala glutamate responses to calcitonin gene-related peptide DOI
Rebecca M. Lorsung, Nathan Cramer, Jason Bondoc Alipio

et al.

Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 45(2), P. e1898242024 - e1898242024

Published: Dec. 11, 2024

Women are disproportionately affected by chronic pain compared with men. While societal and environmental factors contribute to this disparity, sex-based biological differences in the processing of also believed play significant roles. The central lateral nucleus amygdala (CeLC) is a key region for emotional-affective dimension pain, prime target exploring sex since recent study demonstrated CGRP actions region. Inputs CeLC from parabrachial (PB) causal role aversive release both glutamate calcitonin gene-related peptide (CGRP). thought crucial potentiating glutamatergic signaling CeLC. However, it not known if CGRP-mediated synaptic plasticity occurs similarly males females. Here, we tested hypothesis that female neurons experience greater potentiation than following endogenous exposure. Using trains optical stimuli evoke transient PB terminals CeLC, find subsequent responses preferentially potentiated mice. This was dependent involved postsynaptic mechanism. difference sensitivity may explain affective processing.

Language: Английский

Sex differences in central amygdala glutamate responses to calcitonin gene-related peptide DOI
Rebecca M. Lorsung, Nathan Cramer, Jason Bondoc Alipio

et al.

Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 45(2), P. e1898242024 - e1898242024

Published: Dec. 11, 2024

Women are disproportionately affected by chronic pain compared with men. While societal and environmental factors contribute to this disparity, sex-based biological differences in the processing of also believed play significant roles. The central lateral nucleus amygdala (CeLC) is a key region for emotional-affective dimension pain, prime target exploring sex since recent study demonstrated CGRP actions region. Inputs CeLC from parabrachial (PB) causal role aversive release both glutamate calcitonin gene-related peptide (CGRP). thought crucial potentiating glutamatergic signaling CeLC. However, it not known if CGRP-mediated synaptic plasticity occurs similarly males females. Here, we tested hypothesis that female neurons experience greater potentiation than following endogenous exposure. Using trains optical stimuli evoke transient PB terminals CeLC, find subsequent responses preferentially potentiated mice. This was dependent involved postsynaptic mechanism. difference sensitivity may explain affective processing.

Language: Английский

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