Evaluation of the Antidiabetic Effect of Aqueous Extract of Imperata Cylindrica (Poaceae) Roots in Wistar Ratsct of Aqueous Extract of Imperata Cylindrica (Poaceae) Roots in Wistar Rats DOI Creative Commons

Olivier Tahadjou,

Sansan Philippe Kambou,

Kouassi Denis Bédou

et al.

Journal of Applied Biotechnology, Journal Year: 2024, Volume and Issue: 11(1), P. 1 - 1

Published: Aug. 29, 2024

Diabetes, which has become a major public health problem, is treated by certain plants in our regions, including Imperata cylindrica. The aqueous extract of the dried roots this plant was obtained infusion. various chemical groups total were evaluated using methods described Houghton and Raman. Rats made diabetic injection single dose (50mg/kg bw) streptozotocin with different doses compared glibenclamide. Treatment began 28 days after lasted days. Blood glucose glycated hemoglobin (HbA1c) measured before injection, treatment extract, one week cessation treatment. Histopathological sections pancreas then taken.The phytochemical screening study carried out on showed that it contains sterols, polyterpenes, polyphenols, flavonoids, alkaloids saponosides. levels normal rats ranged from 0.902±0.009 g/L to 1.013±0.00 3.377±0.130% 3.87±0.186%. Untreated blood increased 3.26±0.26 9.583±0.322% at D63 respectively. One discontinuation treatment, values glibenclamide remained batches extract. Histological reconstituting cells. normalizes lowers hemoglobin, justifying its traditional use diabetes.

Language: Английский

Scarce and unpredictable, yet obesogenic: modeling the impact of food insecurity on adiposity in mice DOI
Alessandro Bartolomucci, John R. Speakman

Obesity, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Language: Английский

Citations

0
Human Vascularized Adipose Tissue Organoids Reveal Endothelial-Adipocyte Interactions at Single-Cell Resolution DOI

Maren Marder,

Sandra Wiedenmann, Fabiana Oliveira

et al.

Published: Jan. 1, 2025

White adipose tissue (WAT) is essential for energy storage and metabolic homeostasis, plays a central role in the pathology of obesity type 2 diabetes. Vascular networks within WAT support oxygen nutrient supply regulate adipogenesis, yet mechanisms underlying endothelial-adipocyte crosstalk under both healthy dysfunctional conditions remain unclear. Here, we present vascularized organoid (vAO) model engineered from human adipose-derived stem cells induced pluripotent cell-derived endothelial (SC-ECs). The 3D cell culture enables adipogenesis angiogenesis controlled conditions. vAOs demonstrated enhanced β-adrenergic-induced lipolysis insulin-stimulated glucose uptake. Single-cell transcriptomics revealed distinct stromal subtypes, including perivascular adipocyte precursors maturing SC-ECs shaped by PDGFB signaling. knockdown disrupted alignment lipolysis, highlighting critical endothelial-pericyte interactions. This study provides versatile platform to dissect explore pathways that control WAT-remodeling determine its function. Our vAO therefore presents unique molecularly functionally patient-specific dysfunctions, advancing our portfolio personalized therapies importance communication.

Language: Английский

Citations

0
Neuroprotective effects of vitamin C on hypoxic-ischemic brain injury in neonatal mice DOI

Kaiyi Liu,

Xiaoqing Chen,

Fangbing Chen

et al.

Pediatric Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Language: Английский

Citations

0
CD63, a new therapeutical candidate for cholesterol homeostasis regulation through extracellular vesicles? DOI Open Access
Julien Saint‐Pol, Laurence Fénart

Extracellular Vesicles and Circulating Nucleic Acids, Journal Year: 2025, Volume and Issue: 6(1), P. 166 - 70

Published: March 19, 2025

CD63 is a tetraspanin initially associated with late endosomes and contributes to numerous functions at the cell level, such as intracellular endosomal lysosomal trafficking, adhesion, motility. also plays key role in biogenesis release of exosomes, i.e., small extracellular vesicles (EVs) origin, facilitating formation multivesicular bodies (MVBs), coordination sorting complexes required for transport (ESCRT) machinery, selection cargoes carried by future fusion MVBs plasma membrane exosome release. In recent publication Nature Cell Biology , Guillaume van Niel’s team provides arguments favor another EV-linked function CD63, namely regulation cholesterol storage EVs endogenous origin. Complemented two other publications from teams Keisuke Ito Xabier Ostreikoetxea, which respectively describe (i) mitochondrial metabolism on (ii) link between reduced CD63+ dyslipidemia, these highlight homeostasis through exosomes more widely physiological pathological conditions. Future research may thus redefine our approach cellular lipid management therapeutic delivery.

Language: Английский

Citations

0
Failure of inflammation hypothesis in the pathogenesis of type 2 diabetes DOI
Jianping Ye

Obesity Medicine, Journal Year: 2024, Volume and Issue: unknown, P. 100565 - 100565

Published: Nov. 1, 2024

Language: Английский

Citations

2
Polypropylene microplastics triggered mouse kidney lipidome reprogramming combined with ROS stress as revealed by lipidomics and Raman biospectra DOI
Mingying Liu, Miao Wang, Xiang Sun

et al.

Chemosphere, Journal Year: 2024, Volume and Issue: 370, P. 143926 - 143926

Published: Dec. 19, 2024

Language: Английский

Citations

2
Evaluation of the Antidiabetic Effect of Aqueous Extract of Imperata Cylindrica (Poaceae) Roots in Wistar Ratsct of Aqueous Extract of Imperata Cylindrica (Poaceae) Roots in Wistar Rats DOI Creative Commons

Olivier Tahadjou,

Sansan Philippe Kambou,

Kouassi Denis Bédou

et al.

Journal of Applied Biotechnology, Journal Year: 2024, Volume and Issue: 11(1), P. 1 - 1

Published: Aug. 29, 2024

Diabetes, which has become a major public health problem, is treated by certain plants in our regions, including Imperata cylindrica. The aqueous extract of the dried roots this plant was obtained infusion. various chemical groups total were evaluated using methods described Houghton and Raman. Rats made diabetic injection single dose (50mg/kg bw) streptozotocin with different doses compared glibenclamide. Treatment began 28 days after lasted days. Blood glucose glycated hemoglobin (HbA1c) measured before injection, treatment extract, one week cessation treatment. Histopathological sections pancreas then taken.The phytochemical screening study carried out on showed that it contains sterols, polyterpenes, polyphenols, flavonoids, alkaloids saponosides. levels normal rats ranged from 0.902±0.009 g/L to 1.013±0.00 3.377±0.130% 3.87±0.186%. Untreated blood increased 3.26±0.26 9.583±0.322% at D63 respectively. One discontinuation treatment, values glibenclamide remained batches extract. Histological reconstituting cells. normalizes lowers hemoglobin, justifying its traditional use diabetes.

Language: Английский

Citations

1