Annals of Surgery Open,
Journal Year:
2025,
Volume and Issue:
6(2), P. e566 - e566
Published: April 2, 2025
Objective:
In
a
randomized,
embedded,
multifactorial,
adaptive
platform
(REMAP)
trial,
we
hypothesized
that
perioperative
metformin
would
improve
postoperative
time
alive
and
out
of
the
hospital,
defined
by
90-day
hospital-free
days
(HFD-90),
among
nondiabetic
aged
adults.
Background:
As
our
population
ages,
patients
are
increasingly
frail
requiring
an
emphasis
on
treatments
to
counteract
their
diminished
resilience,
especially
following
stress
surgery.
Growing
literature
supports
as
antiaging
anti-inflammatory
therapy
with
beneficial
effects
extending
into
period.
Methods:
At-risk
adults
(≥60
years)
scheduled
for
elective
surgical
interventions
were
randomized
placebo
(N
=
√3)
or
1:1:1;
500
mg:1000
mg:1500
mg)
short
(7–28
days),
intermediate
(29–90
long
(>90
days)
preoperative
durations.
An
sample
size
1000–2500)
identify
at
least
15%
improvement
in
HFD-90
>1
doses.
Using
intention-to-treat
analysis,
Bayesian
ordinal
logistic
regression
compared
frequentist
reoperation
readmission.
Results:
Before
trial
closure,
302
106
placebo,
N
196
[N
64,
mg;
66,
1000
1500
mg])
without
differences
baseline
demographics
(age
68
±
6
years,
45%
females,
92%
White
race)
(spine
[29%],
general
[38%],
colorectal
[13%],
other
[20%]).
The
odds
did
not
significantly
differ
between
all
doses
duration
placebo.
There
no
reintervention
(OR
1.1
[95%
CI,
0.6–2.0])
readmission
1.5
0.7–2.8]).
Conclusions:
Pretreatment
outcomes
this
REMAP
although
enrollment
was
markedly
limited
COVID-19
pandemic
is
underpowered.
Molecules,
Journal Year:
2025,
Volume and Issue:
30(4), P. 816 - 816
Published: Feb. 10, 2025
Aging
represents
a
complex
biological
phenomenon
marked
by
the
progressive
deterioration
of
physiological
functions
over
time,
reduced
resilience,
and
increased
vulnerability
to
age-related
diseases,
ultimately
culminating
in
mortality.
Recent
research
has
uncovered
diverse
molecular
mechanisms
through
which
metformin
extends
its
benefits
beyond
glycemic
control,
presenting
it
as
promising
intervention
against
aging.
This
review
delves
into
anti-aging
properties
metformin,
highlighting
role
mitochondrial
energy
modulation,
activation
AMPK-mTOR
signaling
pathway,
stimulation
autophagy,
mitigation
inflammation
linked
cellular
Furthermore,
we
discuss
influence
on
epigenetic
modifications
that
underpin
genomic
stability
homeostasis.
Metformin's
potential
addressing
age-associated
disorders
including
metabolic,
cardiovascular,
neurodegenerative
diseases
is
also
explored.
The
Targeting
with
Metformin
(TAME)
trial
aims
provide
key
evidence
efficacy
delaying
aging
humans.
Despite
these
insights,
significant
challenges
persist
gaining
more
comprehensive
understanding
underlying
mechanisms,
determining
optimal
dosing
strategies,
evaluating
long-term
safety
non-diabetic
populations.
Addressing
crucial
fully
realizing
metformin's
an
therapeutic.
The Journal of Cardiovascular Aging,
Journal Year:
2025,
Volume and Issue:
5(1)
Published: Jan. 15, 2025
Aging
leads
to
structural
and
functional
deterioration
of
the
heart,
reducing
its
capacity
withstand
internal
external
stressors
consequently
increasing
risk
heart
failure.
Exercise
is
a
potent
modulator
cardiovascular
metabolic
health,
offering
numerous
physiological
benefits
that
can
persist
throughout
aging
process.
Studies
suggest
exercise
decelerate
age-related
cardiac
mitigate
In
this
review,
we
discuss
recent
advances
in
our
understanding
exercise-mediated
molecular
cellular
adaptations
could
serve
as
therapeutic
targets
for
remodeling
decline.
We
also
explore
how
exercise-induced
changes
may
enhance
resilience
with
age,
examine
sex
differences
response
exercise,
highlight
value
murine
models
research
tools
identifying
novel
strategies
combat
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 1, 2025
Abstract
Aging
is
associated
with
progressive
tissue
dysfunction,
leading
to
frailty
and
mortality.
Characterizing
aging
features,
such
as
changes
in
gene
expression
dynamics,
shared
across
tissues
or
specific
each
tissue,
crucial
for
understanding
systemic
local
factors
contributing
the
process.
We
performed
RNA-sequencing
on
13
at
6
different
ages
African
turquoise
killifish,
shortest-lived
vertebrate
that
can
be
raised
captivity.
This
comprehensive,
sex-balanced
‘atlas’
dataset
reveals
varying
strength
of
sex-age
interactions
killifish
identifies
age-altered
biological
pathways
are
evolutionarily
conserved.
Demonstrating
utility
this
resource,
we
discovered
head
kidney
exhibits
a
myeloid
bias
during
aging,
phenomenon
more
pronounced
females
than
males.
In
addition,
developed
tissue-specific
‘transcriptomic
clocks’
identified
biomarkers
predictive
chronological
age.
show
importance
sex-specific
clocks
selected
use
evaluate
dietary
intervention
killifish.
Our
work
provides
comprehensive
resource
studying
dynamics
powerful
model.
Journal of Translational Internal Medicine,
Journal Year:
2025,
Volume and Issue:
13(1), P. 33 - 47
Published: Feb. 1, 2025
Aging
and
age-related
diseases
are
major
drivers
of
multimorbidity
mortality
worldwide.
Cellular
senescence
is
a
hallmark
aging.
The
accumulation
senescent
cells
causally
associated
with
pathogenesis
various
age-associated
disorders.
Due
to
their
promise
for
alleviating
disorders
extending
healthspan,
therapeutic
strategies
targeting
(senotherapies)
as
means
combat
aging
have
received
much
attention
over
the
past
decade.
Among
conventionally
used
approaches,
one
usage
small-molecule
compounds
specifically
exhibit
cytotoxicity
toward
or
inhibit
deleterious
effects
senescence-associated
secretory
phenotype
(SASP).
Alternatively,
there
immunotherapies
directed
at
surface
antigens
upregulated
in
(seno-antigens),
including
chimeric
antigen
receptor
(CAR)
therapies
senolytic
vaccines.
This
review
gives
an
update
current
status
discovery
development
therapies,
translational
progress
from
preclinical
clinical
trials.
We
highlight
challenges
faced
by
senotherapeutic
context
heterogeneity,
aim
offering
novel
perspectives
future
anti-aging
interventions
aimed
enhancing
healthy
longevity.
Cells,
Journal Year:
2025,
Volume and Issue:
14(7), P. 499 - 499
Published: March 27, 2025
Cellular
senescence
is
an
irreversible
state
of
cell
cycle
arrest.
Senescent
cells
(SCs)
accumulate
in
the
body
with
age
and
secrete
harmful
substances
known
as
senescence-associated
secretory
phenotype
(SASP),
causing
chronic
inflammation;
at
same
time,
inflammation
leads
to
a
decrease
immune
system
function,
immunosenescence,
which
further
accelerates
aging
process.
immunosenescence
are
closely
related
variety
diseases,
including
cardiovascular
metabolic
disorders,
autoimmune
neurodegenerative
diseases.
Studying
mechanisms
cellular
developing
targeted
interventions
crucial
for
improving
function
quality
life
elderly
people.
Here,
we
review
series
recent
studies
focusing
on
molecular
regulation
by
system,
latest
advances
basic
clinical
research
senolytics.
We
summarize
animal
models
research,
well
mechanisms,
strategies,
future
directions
from
immunological
perspective,
hope
laying
foundation
novel
practical
anti-aging
therapies.
