Role of microbiota in pain: From bench to bedside DOI Creative Commons

Huiguang Ren,

Bo Cao,

Qixuan Xu

et al.

iMetaOmics., Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Abstract Interactions between the microbiota and host have been proven to be critical regulators of homeostasis, pain perception is no exception. Emerging evidence has identified mechanisms by which dysbiosis contributes hyperalgesia revealed potential value microbiota‐associated therapies in management. Herein, authors introduce basic knowledge for readers who are not simultaneously majoring these two fields. The clarified underlying regulation outlined terms three ways. This review summarizes current advancements management microbiology research clinicians wish focus on this area. Probiotics, fecal transplantation, other methods modulation entered clinical translation. further propose present limitations prospects high‐quality development preclinical investigations. Importantly, despite large amount attention given gut bacteria, also puts forward great expectations role nongut nonbacterial sensation. Efforts decipher functions will help promote achievements from bench bedside.

Language: Английский

Fertilization-recruited Actinomycetota enhances nutrient and energy metabolisms to favor plant growth and arsenic accumulation in Pteris vittata DOI
Yong-He Han, Yixi Li,

Xi-Wen Cui

et al.

Journal of environmental chemical engineering, Journal Year: 2025, Volume and Issue: unknown, P. 116043 - 116043

Published: March 1, 2025

Language: Английский

Citations

1
Droplet microfluidics: unveiling the hidden complexity of the human microbiome DOI

Yibin Xu,

Zhiyi Wang, Caiming Li

et al.

Lab on a Chip, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

The human microbiome is vital for health. Droplet microfluidics offers a versatile toolbox research, enabling single-cell sequencing, cultivation, and functional analyses to deepen our understanding drive innovations.

Language: Английский

Citations

0
Ribosomal protein phylogeography offers quantitative insights into the efficacy of genome-resolved surveys of microbial communities DOI Creative Commons
Matthew S. Schechter, Florian Trigodet, Iva Veseli

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

The increasing availability of microbial genomes is essential to gain insights into ecology and evolution that can propel biotechnological biomedical advances. Recent advances in genome recovery have significantly expanded the catalogue from diverse habitats. However, ability explain how well a set account for diversity given environment remains challenging individual studies or biome-specific databases. Here we present EcoPhylo, computational workflow characterize phylogeography any gene family through integrated analyses metagenomes, our application this approach ribosomal proteins quantify phylogeny-aware rates across three biomes. Our findings show vary widely taxa biomes, single amplified genomes, metagenome-assembled isolate non-uniform yet quantifiable representation environmental microbes. EcoPhylo reveals highly resolved, reference-free, multi-domain phylogenies conjunction with distribution patterns clades environments, providing means assess benchmark biome-level collections.

Language: Английский

Citations

0
Chemistry-based vectors map the chemical space of natural biomes from untargeted mass spectrometry data DOI Creative Commons
Pilleriin Peets,

Aristeidis Litos,

Kai Dührkop

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Abstract Untargeted metabolomics can comprehensively map the chemical space of a biome, but is limited by low annotation rates (<10%). We used chemistry-based vectors, consisting molecular fingerprints or compound classes, predicted from mass spectrometry data, to characterize compounds and samples. These characteristics vectors (CCVs) estimate fraction with specific properties in sample. Unlike aligned MS1 data intensity information, CCVs incorporate actual compounds, offering deeper insights into sample comparisons. Thus, we identified key classes differentiating biomes, such as ethers which are enriched environmental while steroids animal host-related biomes. In biomes greater variability, revealed clustering organonitrogen distal gut lipids secretions. thus enhance interpretation untargeted metabolomic providing quantifiable generalizable understanding natural

Language: Английский

Citations

0
Recruitment of copiotrophic and autotrophic bacteria by hyperaccumulators enhances nutrient cycling to reclaim degraded soils at abandoned rare earth element mining sites DOI
Yong-He Han,

Xi-Wen Cui,

Haiyan Wang

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 488, P. 137351 - 137351

Published: Jan. 26, 2025

Language: Английский

Citations

0
Role of microbiota in pain: From bench to bedside DOI Creative Commons

Huiguang Ren,

Bo Cao,

Qixuan Xu

et al.

iMetaOmics., Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Abstract Interactions between the microbiota and host have been proven to be critical regulators of homeostasis, pain perception is no exception. Emerging evidence has identified mechanisms by which dysbiosis contributes hyperalgesia revealed potential value microbiota‐associated therapies in management. Herein, authors introduce basic knowledge for readers who are not simultaneously majoring these two fields. The clarified underlying regulation outlined terms three ways. This review summarizes current advancements management microbiology research clinicians wish focus on this area. Probiotics, fecal transplantation, other methods modulation entered clinical translation. further propose present limitations prospects high‐quality development preclinical investigations. Importantly, despite large amount attention given gut bacteria, also puts forward great expectations role nongut nonbacterial sensation. Efforts decipher functions will help promote achievements from bench bedside.

Language: Английский

Citations

0