Nature Microbiology, Journal Year: 2024, Volume and Issue: 9(11), P. 2799 - 2800
Published: Oct. 28, 2024
Language: Английский
Nature Microbiology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 13, 2025
Despite ongoing antibiotic development, evolution of resistance may render candidate antibiotics ineffective. Here we studied in vitro emergence to 13 introduced after 2017 or currently compared with in-use antibiotics. Laboratory showed that clinically relevant arises within 60 days exposure Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii and Pseudomonas aeruginosa, priority Gram-negative ESKAPE pathogens. Resistance mutations are already present natural populations pathogens, indicating nature can emerge through selection pre-existing bacterial variants. Functional metagenomics mobile genes candidates prevalent clinical isolates, soil human gut microbiomes. Overall, show similar susceptibility development as use, the corresponding mechanisms overlap. However, certain combinations strains were less prone developing resistance, revealing potential narrow-spectrum antibacterial therapies could remain effective. Finally, develop criteria guide efforts effective candidates. An extensive experimental analysis post-2017 bacteria reveals dynamics acquisition, mutational targets presence environmental isolates.
Language: Английский
Citations
4
Microbiological Research, Journal Year: 2025, Volume and Issue: unknown, P. 128083 - 128083
Published: Jan. 1, 2025
Language: Английский
Citations
1
Antibiotics, Journal Year: 2025, Volume and Issue: 14(3), P. 221 - 221
Published: Feb. 21, 2025
Background/Objectives: Antimicrobial resistance poses a major public health challenge. The World Health Organization has identified 15 priority pathogens that require prompt development of new antibiotics. This review systematically evaluates the antibacterial most significant bacterial pathogens, currently available treatment options, as well complementary approaches for management infections caused by challenging multidrug-resistant (MDR) bacteria. For carbapenem-resistant Gram-negative bacteria, options include combinations beta-lactam antibiotics and beta-lactamase inhibitors, novel siderophore cephalosporin, known cefiderocol, older like polymixins tigecycline. Treatment Gram-positive bacteria are vancomycin, daptomycin, linezolid, etc. Although stagnated, various agents with properties in clinical preclinical trials. Non-antibiotic strategies encompass antibiotic potentiators, bacteriophage therapy, antivirulence therapeutics, antimicrobial peptides, nanomaterials, host-directed vaccines, antibodies, plant-based products, repurposed drugs, their combinations, including those used alongside Significant challenges exist developing antimicrobials, particularly related to scientific technical issues, along policy economic factors. Currently, alternative not part routine protocols. Conclusions Future Directions: There is an urgent need expedite treating MDR requires multidisciplinary approach involves collaboration across research, healthcare, regulatory bodies. Suggested crucial addressing this challenge should be backed rational use, enhanced infection control practices, improved surveillance systems emerging pathogens.
Language: Английский
Citations
1
iMetaOmics., Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 14, 2025
Abstract Recent advancements in analytical techniques have unveiled the spatiotemporal diversity of gastrointestinal tract (GIT) microbiota and their associations with host well‐being. Despite these insights, precise regulation GIT remains a significant challenge. Currently, microbial regulatory strategies, including fecal transplantation (FMT), synthetic communities (SynComs), genetically engineered microorganisms (GEMs), phages, nanomaterials, are increasingly utilized for influence on microbiota. This review emphasizes necessity developing targeted strategies provides comprehensive summary comparison approaches to explore potential. We discuss recent focusing mechanisms, efficacy, safety considerations, clinical trials, optimization at application level. Finally, we highlight support methods optimizing modulation timing regulation, selection targets, importance monitoring environment guide effective interventions.
Language: Английский
Citations
0
Clinical Microbiology Newsletter, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0
Microorganisms, Journal Year: 2025, Volume and Issue: 13(1), P. 176 - 176
Published: Jan. 16, 2025
Antibiotic resistance is on the WHO's top 10 list of global public health threats due to its rapid emergence and spread but also because high morbidity mortality associated with it. Amongst main species driving this phenomenon A. baumannii, a member ESKAPE group medical assistance-associated infections causing famous for extensively drug-resistant phenotypes. Our findings note 91.52% frequency carbapenem-resistant baumannii (XDR CRAB) phenotype amongst clinical isolates from multiple hospitals in two major cities northwestern central Romania, harboring antibiotic genes such as blaOXA-23-like 108 (91.5%) isolates, blaOXA-24/40-like 88 (74.6%) blaNDM 29 (25%) ArmA 75 (63.6%) ant(3″)-I 69 (58.5%) sul1 113 (95.76%) isolates. The although nearly identical phenotype, displayed different genotypical profiles, varying degrees similarity across cities, raising possibility both local outbreaks single clone widespread dissemination resistant
Language: Английский
Citations
0
Microbiology Resource Announcements, Journal Year: 2025, Volume and Issue: unknown
Published: March 25, 2025
ABSTRACT We report the genome of a phage phi1_092033, isolated from sewage, which effectively lyses carbapenem-resistant Acinetobacter baumannii strains various capsule types. phi1_092033 represents species genus Saclayvirus . Its consists 104,070 bp, with GC content 38%, containing 188 protein-coding sequences and 13 tRNAs.
Language: Английский
Citations
0
Microbiology Resource Announcements, Journal Year: 2025, Volume and Issue: unknown
Published: April 15, 2025
ABSTRACT We describe the genome of a lytic phage isolated from sewage, which is capable lysing ST2 KL104-type carbapenem-resistant Acinetobacter baumannii strains. The 167,208 bp in length, has guanine-cytosine (GC) content 37%, and includes 266 protein-coding sequences five tRNAs.
Language: Английский
Citations
0
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz, Journal Year: 2025, Volume and Issue: unknown
Published: April 28, 2025
Citations
0
Nature Microbiology, Journal Year: 2024, Volume and Issue: 9(11), P. 2799 - 2800
Published: Oct. 28, 2024
Language: Английский
Citations
0