Medicine Plus, Journal Year: 2024, Volume and Issue: unknown, P. 100068 - 100068
Published: Dec. 1, 2024
Language: Английский
Nature Reviews Neurology, Journal Year: 2025, Volume and Issue: 21(2), P. 66 - 66
Published: Jan. 17, 2025
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0
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2108 - 2108
Published: Feb. 27, 2025
Gliomas, particularly glioblastoma (GBM), are among the most challenging brain tumors due to their complex and dynamic tumor microenvironment (TME). The TME plays a pivotal role in progression, immune evasion, resistance therapy through intricate interactions glioma cells, components, neurons, astrocytes, extracellular matrix, blood-brain barrier. Targeting has demonstrated potential, with immunotherapies such as checkpoint inhibitors neoadjuvant therapies enhancing responses. Nonetheless, overcoming immunosuppressive landscape metabolic adaptations continues pose significant challenges. This review explores diverse cellular molecular mechanisms that shape TME. A deeper understanding of these holds promise for providing novel therapeutic opportunities improve treatment outcomes.
Language: Английский
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Cell chemical biology, Journal Year: 2025, Volume and Issue: 32(3), P. 386 - 388
Published: March 1, 2025
Language: Английский
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0
Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217667 - 217667
Published: March 1, 2025
Language: Английский
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0
Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Glioblastoma (GBM) progression and therapeutic resistance are significantly influenced by complex interactions between tumor cells the brain microenvironment, particularly neurons. However, studying these in physiologically relevant conditions has remained challenging due to limitations existing model systems. Here, we present hGliCS (human glioma-cortical spheroid), a novel fully human that overcomes key of current approaches combining patient-derived GBM with mature cortical neurons derived from induced pluripotent stem cells. We demonstrate develop three critical hallmark features observed patients: (i) formation microtubes enabling intercellular communication, (ii) establishment neuron-glioma synapses, (iii) development an interconnected network coordinated calcium signaling. Single-cell RNA sequencing reveals exhibit cellular heterogeneity transcriptional profiles remarkably similar those mouse xenografts, including activation oncogenic pathways neuronal-like features. Notably, while showed substantial adaptation neural environment, maintained their core identity only subtle alterations glutamate signaling structural gene expression. validate as drug screening platform demonstrating patterns standard chemotherapy radiation clinical observations. Furthermore, show model's utility testing compounds targeting cell proliferation tumor-specific neurobiological features, respectively. This system provides new opportunities for biology tumor-neuron controlled environment. By bridging gap simplified vitro systems vivo models, represents promising personalized medicine treatment.
Language: Английский
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International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3057 - 3057
Published: March 27, 2025
Tumor innervation is a complex interaction between nerves and cancer cells that consists of axons invading tumors, its complexity remains largely unknown in humans. Although some retrospective studies have provided important insights into the relationship further knowledge required about this biological process. Animal experiments elucidated several molecular cellular mechanisms tumor innervation; however, no experimental models currently exist to study interactions human nerve cells. Human pluripotent stem can differentiate neurons for research purposes; use these with unexplored. Hence, here we analyze potential derived from unravel poorly understood innervation.
Language: Английский
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0
Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217660 - 217660
Published: March 1, 2025
Language: Английский
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0
Receptors, Journal Year: 2025, Volume and Issue: 4(2), P. 9 - 9
Published: April 2, 2025
Bioelectric membrane potentials regulate cellular growth, differentiation, and movement. Disruptions in bioelectric signaling are strongly linked to cancer development, as abnormal ion channel activity can drive tumor progression. In breast cancer, dysfunction neuroreceptor-related pathways play significant roles the cell cycle, epithelial–mesenchymal transition, angiogenesis, inflammation, microenvironment, Neuroreceptors critical not only initiating advancing but also conferring resistance treatments. a key role, with dopamine receptor D2 activation reducing growth by 40% preclinical models, while serotonin has been shown promote transition (EMT), increasing invasiveness. Advances understanding these biological mechanisms could lead more cost-effective less invasive therapeutic strategies treat tumors. This review explores expanding evidence connecting focusing on neuroreceptor pharmacology transformative approach. Examining modulation of bioelectricity through influence progression integrating insights into development offers promising path for addressing treatment challenges improving precision managing aggressive subtypes.
Language: Английский
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0
Medicine Plus, Journal Year: 2024, Volume and Issue: unknown, P. 100068 - 100068
Published: Dec. 1, 2024
Language: Английский
Citations
0