The Associations Between Irregular Breakfast and Late-Night Snacking with Metabolic dysfunction-Associated Steatotic Liver Disease

Clinical Nutrition, Journal Year: 2025, Volume and Issue: 46, P. 52 - 59

Published: Jan. 20, 2025

Language: Английский

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Hangry hairs: intermittent fasting linked to hair loss

Cell Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Language: Английский

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MicroRNA-155 targets p65 to regulate PD-L1 expression in the early pregnancy endometrium

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 22, 2025

Reproductive disorders in dairy cows represent a significant challenge to the advancement of industry. Pregnancy success is closely related mechanism immune tolerance, with PD-1/PD-L1 signaling pathway playing role regulation, which associated tolerance and pregnancy maintenance. MicroRNAs can regulate pivotal molecules within pathway, physiological activities, disease processes. p65 PD-L1 expression was significantly increased early pregnant uterine epithelium. In contrast, homogeneous endometrial epithelium E2 P4 co-stimulated bEECs changed stimulation time concentration. MiR-155 reduced identified as molecular target miR-155 using dual luciferase assay mimics/inhibitor transfection, inhibited by binding 3'-UTR mRNA. The regulation confirmed through knockdown si-p65 overexpression pcDNA3.1-p65. context pregnancy, observed p65, thereby regulating at

Language: Английский

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Caloric Restriction Exacerbates Renal Injury and Fibrosis Following Ischemia-Reperfusion by Modulating mTORC1 Signaling and Autophagy

Redox Biology, Journal Year: 2025, Volume and Issue: 80, P. 103500 - 103500

Published: Jan. 18, 2025

This study investigates the effects of caloric restriction (CR) on renal injury and fibrosis following ischemia-reperfusion (IRI), with a focus roles mechanistic/mammalian target rapamycin complex 1 (mTORC1) signaling autophagy. A mouse model unilateral IRI or without CR was used. Renal function assessed through serum creatinine blood urea nitrogen levels, while histological analysis molecular assays evaluated tubular injury, fibrosis, mTORC1 signaling, autophagy activation. Inducible tubule-specific Atg7 knockout mice inhibitor 3-MA were used to elucidate autophagy's role in outcomes. exacerbated dysfunction, mice, associated suppressed enhanced Rapamycin, an inhibitor, mimicked CR, further supporting involvement mTORC1-autophagy pathway. Tubule-specific mitigated these effects, indicating central for CR-induced damage. Glucose supplementation, but not branched-chain amino acids (BCAAs), alleviated dysfunction by restoring Finally, we identified leucyl-tRNA synthetase (LARS1) as key mediator nutrient sensing activation, demonstrating its glucose dependency under conditions. Our provides novel insights into interplay between metabolism, IRI-induced damages, offering potential therapeutic targets mitigating CR-associated complications after IRI.

Language: Английский

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Fasting can reduce weight — but also hair growth

Nature, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 13, 2024

Language: Английский

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