Microbiome–metabolome dynamics associated with impaired glucose control and responses to lifestyle changes DOI Creative Commons
Hao Wu,

Bo‐Min Lv,

Luqian Zhi

et al.

Nature Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Abstract Type 2 diabetes (T2D) is a complex disease shaped by genetic and environmental factors, including the gut microbiome. Recent research revealed pathophysiological heterogeneity distinct subgroups in both T2D prediabetes, prompting exploration of personalized risk factors. Using metabolomics two Swedish cohorts ( n = 1,167), we identified over 500 blood metabolites associated with impaired glucose control, approximately one-third linked to an altered Our findings metabolic disruptions microbiome–metabolome dynamics as potential mediators compromised homeostasis, illustrated interactions between Hominifimenecus microfluidus Blautia wexlerae via hippurate. Short-term lifestyle changes, for example, diet exercise, modulated microbiome-associated lifestyle-specific manner. This study suggests that axis modifiable target management, optimal health benefits achievable through combination modifications.

Language: Английский

Targeting YTHDF2 impacts the epitranscriptome and overcomes tumor therapy resistance DOI
Zhicong Zhao, Li Han, Qiwei Ge

et al.

Trends in Cell Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
The role of YTHDF2 in anti-tumor immunity DOI Creative Commons
Leying Zhang, Cunte Chen, Jia Feng

et al.

Cell investigation., Journal Year: 2025, Volume and Issue: 1(1), P. 100008 - 100008

Published: Feb. 26, 2025

Language: Английский

Citations

0
Ribosomal protein L9 is a potential therapeutic target for B-ALL through the activation of the p53 signaling pathway DOI Creative Commons
Xinxin Li, Wenting Meng, Xi Wang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 27, 2025

B-cell acute lymphocytic leukemia (B-ALL) is a malignant hematological disorder marked by the aberrant proliferation of abnormal B lymphocytes. Although recent advancements have highlighted pivotal role ribosomes in progression B-ALL, specific function ribosomal protein L9 (RPL9), key component structural protein, still unclear. In this study, we observed significant upregulation RPL9 human B-ALL cells compared to normal cells, suggesting RPL9’s potential progression. Enforced knockdown (KD) led decreased and increased apoptosis control group. Furthermore, KD significantly extended survival time NCG mice bearing vivo controls. Mechanistically, our findings indicate that triggers nucleolar stress, disrupts ribosome biosynthesis, activates p53 signaling pathway. Building upon investigation into positive regulatory influence FTO on m 6 A-modified RPL9, discovered overexpression can mitigate activation induced KD. Our further suggest increases MICA/B mRNA expression which serves as crucial ligands NK cell’s NKG2D, potentially heightening their sensitivity cell-mediated cytotoxicity. summary, study suggests suppresses upregulates immunotherapy targets, highlighting important target for conventional B-ALL.

Language: Английский

Citations

0
5-Methylcytosine RNA modification and its roles in cancer and cancer chemotherapy resistance DOI Creative Commons
Li Fang, Tingting Liu, Yi Dong

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 3, 2025

Recent advancements in cancer therapies have improved clinical outcomes, yet therapeutic resistance remains a significant challenge because of its complex mechanisms. Among epigenetic factors, m5C RNA modification is emerging as key player drug resistance, similar to the well-known m6A modification. affects metabolism processes, including splicing, export, translation, and stability, thereby influencing efficacy. This review highlights critical roles modulating chemotherapy, targeted therapy, radiotherapy, immunotherapy. also discusses functions regulators, methyltransferases, demethylases, m5C-binding proteins, essential modulators landscape that contribute dynamic regulatory network. Targeting these components offers promising strategy overcome resistance. We highlight need for further research elucidate specific mechanisms by which contributes develop precise m5C-targeted therapies, presenting m5C-focused strategies potential novel anticancer treatments.

Language: Английский

Citations

0
Microbiome–metabolome dynamics associated with impaired glucose control and responses to lifestyle changes DOI Creative Commons
Hao Wu,

Bo‐Min Lv,

Luqian Zhi

et al.

Nature Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Abstract Type 2 diabetes (T2D) is a complex disease shaped by genetic and environmental factors, including the gut microbiome. Recent research revealed pathophysiological heterogeneity distinct subgroups in both T2D prediabetes, prompting exploration of personalized risk factors. Using metabolomics two Swedish cohorts ( n = 1,167), we identified over 500 blood metabolites associated with impaired glucose control, approximately one-third linked to an altered Our findings metabolic disruptions microbiome–metabolome dynamics as potential mediators compromised homeostasis, illustrated interactions between Hominifimenecus microfluidus Blautia wexlerae via hippurate. Short-term lifestyle changes, for example, diet exercise, modulated microbiome-associated lifestyle-specific manner. This study suggests that axis modifiable target management, optimal health benefits achievable through combination modifications.

Language: Английский

Citations

0