Timing matters: modeling the effects of gestational cannabis exposure on social behavior and microglia in the developing amygdala

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Cannabis is the most frequently used illicit drug during pregnancy, with use steadily increasing in United States as legalization and decriminalization expand to more states. Many pregnant individuals cannabis reduce adverse symptoms of considering it be less harmful than other pharmaceuticals or alcohol. The primary psychoactive component cannabis, delta-9-tetrahydrocannabinol (THC), acts on endocannabinoid (eCB) system, yet whether perturbs neural development fetus poorly understood. Previously we have shown that androgen mediated eCB tone developing amygdala promotes microglial phagocytosis newborn astrocytes which has enduring consequences circuits regulating sex differences social behavior. Microglia are resident immune cells brain express both receptors CB1R CB2R, making them likely targets modulation by THC. It also plausible exposure THC at differing gestational timepoints can result distinct outcomes, case alcohol exposure. To model human either late early exposed rodents directly postnatal period via intraperitoneal (IP) injection utero prenatal dam IP respectively. Here show results specific changes well behavior juvenile period. Interestingly resulted inverse These findings highlight differential effects across gestation.

Language: Английский

Analyzing automation: Two studies test methods that track rodents’ social interactions, children’s speech characteristics

The Transmitter, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Evaluation of unsupervised learning algorithms for the classification of behavior from pose estimation data

Patterns, Journal Year: 2025, Volume and Issue: unknown, P. 101237 - 101237

Published: April 1, 2025

Language: Английский