Recent Advances in Synthesis and Applications of Calixarene Derivatives Endowed with Anticancer Activity

Molecules, Journal Year: 2024, Volume and Issue: 29(17), P. 4240 - 4240

Published: Sept. 6, 2024

Calix[n]arenes, macrocycles constituted of 4-8 phenol moieties linked through methylene bridges, are stable molecules that can be selectively functionalised at the upper or lower rim. It has already been demonstrated calixarene derivatives biologically pharmacologically active compounds. More recently, suitably calixarenes and analogues (dihomooxacalixarenes, thiacalixarenes, calix[4]resorcinols, azacalixarenes, calixpyrroles, pillarenes) were found to act as anticancer agents, least in vitro assays. We reporting on latest progress this research field.

Language: Английский

Phosphorus Heterocycles and Their Biological Applications

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(45)

Published: Dec. 1, 2024

Abstract Life of the living organism is based on phosphorous, and it involved in almost all important biological biochemical processes such as energy transfer, bone development storing genetic information. Many therapeutic agents having C─P bond, isolated naturally well widely used daily clinical practices are phosphorus‐containing drugs (e.g: phosphotriesters, phosphonates, phosphinates, phosphine oxides, phosphoric amides, bisphosphonates, anhydrides, etc.) growing further. The phosphorus heterocycles (PHs) integrate merits both atom heterocyclic scaffolds representing an class organophosphorus compounds, which constantly drawing attention among industrial scientific society these compounds have shown varieties related applications. Owing to its seminal importance PHs inspired a whole generation medicinal chemists come up with novel containing phosphorous atom. This review focused mainly compilation different classes bioactive skeletons (which includes within ring system or substituted attached another system) other material chemistry applications since year 2000 onwards barring their synthetic routes.

Language: Английский

Water-Soluble Polyglycidol-Grafted Ladder Calix Resorcinarene Oligomers with Open Chain and Cyclic Topologies: Synthesis, Characteristics, and Biological Evaluation

Polymers, Journal Year: 2024, Volume and Issue: 16(22), P. 3219 - 3219

Published: Nov. 20, 2024

Ladder oligomers containing calixarene skeletons in the main chain-calix[4]resorcinarene (CRA) ladder macromolecules with open chain and cyclic double ring-like (Noria-type) topologies-bring particular research attention as functional materials various applications. However, there is still a remarkable lack of studies into synthesis fully water-soluble derivatives these interesting macromolecules. Research on this topic would allow their bio-based application niche to be at least revealed. In present study, strategy for polyglycidol-derivatized calix resorcinarene structures introduced. A

Language: Английский