Ferroptosis in thyroid cancer: mechanisms, current status, and treatment DOI Creative Commons
Wenzhi Tian, Xi Su,

Chenchen Hu

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 23, 2025

Thyroid cancer (TC) represents the most prevalent malignancy within endocrine system. In recent years, there has been a marked global increase in incidence of thyroid cancer, garnering substantial scientific interest. Comprehensive investigations into pathogenesis TC have identified significant association with ferroptosis, newly characterized form cell death mediated by iron ions. Distinct from apoptosis, necrosis, and autophagy, ferroptosis is accumulation lipid peroxides reactive oxygen species, culminating cellular damage death.Recent research elucidated connection between initiation, progression, treatment cancer. These findings underscore significance offer valuable insights development novel therapeutic strategies precise predictive markers. The unique mechanisms present opportunities for targeting treatment-resistant cancers. Consequently, regulation may emerge as target, potentially addressing limitations current treatments. Moreover, elucidating molecular underpinning facilitate identification biomarkers early detection prognostication. This review endeavors to synthesize extant knowledge regarding role examine potential implications, propose future trajectories enhance understanding clinical application ferroptosis.

Language: Английский

Ferroptosis in thyroid cancer: mechanisms, current status, and treatment DOI Creative Commons
Wenzhi Tian, Xi Su,

Chenchen Hu

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 23, 2025

Thyroid cancer (TC) represents the most prevalent malignancy within endocrine system. In recent years, there has been a marked global increase in incidence of thyroid cancer, garnering substantial scientific interest. Comprehensive investigations into pathogenesis TC have identified significant association with ferroptosis, newly characterized form cell death mediated by iron ions. Distinct from apoptosis, necrosis, and autophagy, ferroptosis is accumulation lipid peroxides reactive oxygen species, culminating cellular damage death.Recent research elucidated connection between initiation, progression, treatment cancer. These findings underscore significance offer valuable insights development novel therapeutic strategies precise predictive markers. The unique mechanisms present opportunities for targeting treatment-resistant cancers. Consequently, regulation may emerge as target, potentially addressing limitations current treatments. Moreover, elucidating molecular underpinning facilitate identification biomarkers early detection prognostication. This review endeavors to synthesize extant knowledge regarding role examine potential implications, propose future trajectories enhance understanding clinical application ferroptosis.

Language: Английский

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