Cited by A Short History of the Atrial Nlrp3 Inflammasome and its Distinct Role in Atrial Fibrillation

Non-coding RNAs affecting NLRP3 inflammasome pathway in diabetic cardiomyopathy: a comprehensive review of potential therapeutic options DOI

Elahe Radmehr,

Niloufar Yazdanpanah,

Nima Rezaei

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 28, 2025

Cardiomyopathies are a heterogeneous group of disorders that can lead to fulminant heart failure and sudden cardiac death. In recent years, the prevalence all types cardiomyopathies has shown an upward trend globally. Up 40% patients with cardiomyopathy-related have diabetes mellitus (DM). With fast global spread DM, DCM is increasing accordingly it remains leading cause morbidity mortality in chronic diabetic patients. NLRP3 inflammasome significantly contributes development pathological progression DCM. Targeting or any mediators along its activation pathway provides new potential therapeutic targets for developing specialized drugs treat this comprehensive review, we sought introduce summarize non-coding RNAs effects targeting signaling We hope general overview aid future research therapies

Language: Английский

Citations

A short history of the atrial NLRP3 inflammasome and its distinct role in atrial fibrillation DOI

Theresa Poppenborg,

Arnela Saljic, Florian Bruns

et al.

Journal of Molecular and Cellular Cardiology, Journal Year: 2025, Volume and Issue: 202, P. 13 - 23

Published: March 6, 2025

Inflammasomes are multiprotein complexes of the innate immune system that mediate inflammatory responses to infection and local systemic stress tissue injury. The principal function is facilitate caspase-1 auto-activation subsequently maturation release effectors interleukin (IL)-1β IL-18. atrial-specific NLRP3 inflammasome a unifying causal feature atrial fibrillation (AF) development, progression recurrence after ablation. Many AF-associated risk factors co-morbidities converge mechanistically on activation this central signaling platform. This review presents historical conceptual development distinct its potential involvement in AF. We follow early observations linking inflammation with AF, emergence an atrial-intrinsic operating within not just cells but also resident fibroblasts cardiomyocytes. outline key developments understanding how effector IL-1β contribute causally cellular tissue-level arrhythmogenesis different pathological settings, candidate therapeutic concepts verified preclinical models cardiomyopathy

Language: Английский

Citations

The Regulatory Role of NcRNAs in Pyroptosis and Disease Pathogenesis DOI

Shaocong Wang,