Advances in the study of key cells and signaling pathways in renal fibrosis and the interventional role of Chinese medicines DOI Creative Commons
Lijuan Liang, Youjun Mi,

Shihan Zhou

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 2, 2024

Renal fibrosis (RF) is a pathological process characterized by the excessive accumulation of extracellular matrix (ECM), which triggers repair cascade in response to stimuli and pathogenic factors, leading activation molecular signaling pathways involved fibrosis. This article discusses key cells, molecules, implicated pathogenesis RF, with particular focus on tubular epithelial cells (TECs), cellular senescence, ferroptosis, autophagy, epithelial-mesenchymal transition (EMT), transforming growth factor-β(TGF-β)/Smad signaling. These factors drive core regulatory that significantly influence RF. A comprehensive understanding their roles essential. Through literature review, we explore recent advancements traditional Chinese medicine (TCM) aimed at reducing RF inhibiting chronic kidney disease (CKD). We summarize, analyze, elaborate important role herbs aiming provide new directions for application prevention treatment, as well scientific guidance clinical practices.

Language: Английский

Advances in the study of key cells and signaling pathways in renal fibrosis and the interventional role of Chinese medicines DOI Creative Commons
Lijuan Liang, Youjun Mi,

Shihan Zhou

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 2, 2024

Renal fibrosis (RF) is a pathological process characterized by the excessive accumulation of extracellular matrix (ECM), which triggers repair cascade in response to stimuli and pathogenic factors, leading activation molecular signaling pathways involved fibrosis. This article discusses key cells, molecules, implicated pathogenesis RF, with particular focus on tubular epithelial cells (TECs), cellular senescence, ferroptosis, autophagy, epithelial-mesenchymal transition (EMT), transforming growth factor-β(TGF-β)/Smad signaling. These factors drive core regulatory that significantly influence RF. A comprehensive understanding their roles essential. Through literature review, we explore recent advancements traditional Chinese medicine (TCM) aimed at reducing RF inhibiting chronic kidney disease (CKD). We summarize, analyze, elaborate important role herbs aiming provide new directions for application prevention treatment, as well scientific guidance clinical practices.

Language: Английский

Citations

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