Plac1+ Tumor Cell‐Treg Interplay Supports Tumorigenesis and Progression of Head and Neck Cancer DOI Creative Commons
Xiaoyan Meng,

Zhonglong Liu,

Lu Zhao

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 8, 2025

Cancer/testis antigen (CTA) family is restricted to germline and tumor cells plays an important role during cancer initiation progression. Five single-cell two bulk RNA-seq datasets are integrated screen genes in the CTAs family, revealing that Placenta specific protein 1 (Plac1) specifically expressed head neck squamous cell carcinoma (HNSCC) cells. Sp1 Transcription (SP1) identified as a regulator of Plac1, which confirmed by cleavage under targets tagmentation (CUT&Tag)-seq. With vitro experiments, vivo subcutaneous tumor, transgenic autochthonous model, it revealed Plac1 expression promotes HNSCC progression inducing epidermal growth factor receptor endocytosis recycling increase PI3K/AKT signaling pathway activity. Then, Plac1+ recruit CD4+ T via CXCL11/CXCR3 induce Treg differentiation PVR/TIGIT, turn activates tumorigenic LTA/LTBR forms reciprocal protumor loop. These findings provide insights into molecular features facilitate development personalized treatment strategies.

Language: Английский

Plac1+ Tumor Cell‐Treg Interplay Supports Tumorigenesis and Progression of Head and Neck Cancer DOI Creative Commons
Xiaoyan Meng,

Zhonglong Liu,

Lu Zhao

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 8, 2025

Cancer/testis antigen (CTA) family is restricted to germline and tumor cells plays an important role during cancer initiation progression. Five single-cell two bulk RNA-seq datasets are integrated screen genes in the CTAs family, revealing that Placenta specific protein 1 (Plac1) specifically expressed head neck squamous cell carcinoma (HNSCC) cells. Sp1 Transcription (SP1) identified as a regulator of Plac1, which confirmed by cleavage under targets tagmentation (CUT&Tag)-seq. With vitro experiments, vivo subcutaneous tumor, transgenic autochthonous model, it revealed Plac1 expression promotes HNSCC progression inducing epidermal growth factor receptor endocytosis recycling increase PI3K/AKT signaling pathway activity. Then, Plac1+ recruit CD4+ T via CXCL11/CXCR3 induce Treg differentiation PVR/TIGIT, turn activates tumorigenic LTA/LTBR forms reciprocal protumor loop. These findings provide insights into molecular features facilitate development personalized treatment strategies.

Language: Английский

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