Exploring Immune-Related Ferroptosis Genes in Thyroid Cancer: A Comprehensive Analysis

Biomedicines, Journal Year: 2025, Volume and Issue: 13(4), P. 903 - 903

Published: April 8, 2025

Background: The increasing incidence and poor outcomes of recurrent thyroid cancer highlight the need for innovative therapies. Ferroptosis, a regulated cell death process linked to tumour microenvironment (TME), offers promising antitumour strategy. This study explored immune-related ferroptosis genes (IRFGs) in uncover novel therapeutic targets. Methods: CIBERSORTx WGCNA were applied data from TCGA-THCA identify hub genes. A prognostic model composed IRFGs was constructed using LASSO Cox regression. Pearson correlation employed analyse relationships between immune features. Single-cell RNA sequencing (scRNA-seq) revealed gene expression subsets, qRT–PCR used validation. Results: Twelve identified through WGCNA, leading classification samples into three distinct subtypes. There significant differences patient among these risk score developed based on six key (ACSL5, HSD17B11, CCL5, NCF2, PSME1, ACTB), which found be closely associated with infiltration responses within TME. as factor (HR = 14.737, 95% CI 1.95–111.65; p 0.009). ScRNA-seq predominant myeloid cells, differential validated normal tissues. Conclusions: integrates bulk single-cell construct robust model, offering new targets improving evaluation patients.

Language: Английский

Global research status and frontiers on ferroptosis in hepatocellular carcinoma: a comprehensive bibliometric and visualized analysis

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 2, 2025

Objective The purpose of this study was to analyze the research hotspots and future trends in field ferroptosis hepatocellular carcinoma past 10 years by using bibliometrics visualization software, provide reference for directions field. Methods Web Science database searched from January 1, 2012, October 30, 2024, annual publication volume, countries, institutions, journals, authors, references, keywords, other information were analyzed bibliometrics, VOSviewer, CiteSpace. Results A total 645 English articles 729 institutions 32 countries included study, with 4545 authors published 261 journals. In three years, 518 published, accounting 80.3%. China has most publications, followed United States. Frontiers Oncology had highest number papers (n=26), while Cell citations (n=1206). current mainly focuses on two aspects: one is mechanism explore new therapeutic targets, exploration methods, such as photodynamic therapy nanomaterials, order inhibit proliferation tumor cells, reduce drug resistance, enhance efficacy regulating ferroptosis, which may become a development trend. Conclusion recent there have been increasing studies association between carcinoma. This first comprehensive bibliometric provides reliable promotes its further development.

Language: Английский