Tumor initiation and early tumorigenesis: molecular mechanisms and interventional targets DOI Creative Commons
Shaosen Zhang,

Xinyi Xiao,

Yonglin Yi

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: June 18, 2024

Abstract Tumorigenesis is a multistep process, with oncogenic mutations in normal cell conferring clonal advantage as the initial event. However, despite pervasive somatic and expansion tissues, their transformation into cancer remains rare event, indicating presence of additional driver events for progression to an irreversible, highly heterogeneous, invasive lesion. Recently, researchers are emphasizing mechanisms environmental tumor risk factors epigenetic alterations that profoundly influencing early malignant evolution, independently inducing mutations. Additionally, evolution tumorigenesis reflects multifaceted interplay between cell-intrinsic identities various cell-extrinsic exert selective pressures either restrain uncontrolled proliferation or allow specific clones progress tumors. by which induce both intrinsic cellular competency remodel stress facilitate not fully understood. In this review, we summarize genetic, epigenetic, external events, effects on co-evolution transformed cells ecosystem during initiation evolution. A deeper understanding earliest molecular holds promise translational applications, predicting individuals at high-risk developing strategies intercept transformation.

Language: Английский

Single-cell transcriptomic analysis of endometriosis DOI
Marcos A. Fonseca,

Marcela Haro,

Kelly N. Wright

et al.

Nature Genetics, Journal Year: 2023, Volume and Issue: 55(2), P. 255 - 267

Published: Jan. 9, 2023

Language: Английский

Citations

89
Endometriosis and adenomyosis: shared pathophysiology DOI Creative Commons
Serdar E. Bulun, Şule Yıldız, Mazhar Adli

et al.

Fertility and Sterility, Journal Year: 2023, Volume and Issue: 119(5), P. 746 - 750

Published: March 15, 2023

Language: Английский

Citations

84
Comparative assessment of genes driving cancer and somatic evolution in non-cancer tissues: an update of the Network of Cancer Genes (NCG) resource DOI Creative Commons
Lisa Dreßler, Michele Bortolomeazzi,

Mohamed Reda Keddar

et al.

Genome biology, Journal Year: 2022, Volume and Issue: 23(1)

Published: Jan. 26, 2022

Abstract Background Genetic alterations of somatic cells can drive non-malignant clone formation and promote cancer initiation. However, the link between these processes remains unclear hampers our understanding tissue homeostasis development. Results Here, we collect a literature-based repertoire 3355 well-known or predicted drivers non-cancer evolution in 122 types 12 tissues. Mapping genes 7953 pan-cancer samples reveals that, despite large size, known compendium is still incomplete biased towards frequently occurring coding mutations. High overlap exists evolution, although significant differences emerge their recurrence. We confirm expand unique properties identify core evolutionarily conserved essential whose germline variation strongly counter-selected. Somatic alteration even one sufficient to clonal expansion but not malignant transformation. Conclusions Our study offers comprehensive overview current genetic events initiating revealing gaps biases that need be addressed. The drivers, literature support, are accessible Network Cancer Genes Healthy Drivers resource at http://www.network-cancer-genes.org/ .

Language: Английский

Citations

77
Cell competition in development, homeostasis and cancer DOI
Sanne M. van Neerven, Louis Vermeulen

Nature Reviews Molecular Cell Biology, Journal Year: 2022, Volume and Issue: 24(3), P. 221 - 236

Published: Sept. 29, 2022

Language: Английский

Citations

77
Tumor initiation and early tumorigenesis: molecular mechanisms and interventional targets DOI Creative Commons
Shaosen Zhang,

Xinyi Xiao,

Yonglin Yi

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: June 18, 2024

Abstract Tumorigenesis is a multistep process, with oncogenic mutations in normal cell conferring clonal advantage as the initial event. However, despite pervasive somatic and expansion tissues, their transformation into cancer remains rare event, indicating presence of additional driver events for progression to an irreversible, highly heterogeneous, invasive lesion. Recently, researchers are emphasizing mechanisms environmental tumor risk factors epigenetic alterations that profoundly influencing early malignant evolution, independently inducing mutations. Additionally, evolution tumorigenesis reflects multifaceted interplay between cell-intrinsic identities various cell-extrinsic exert selective pressures either restrain uncontrolled proliferation or allow specific clones progress tumors. by which induce both intrinsic cellular competency remodel stress facilitate not fully understood. In this review, we summarize genetic, epigenetic, external events, effects on co-evolution transformed cells ecosystem during initiation evolution. A deeper understanding earliest molecular holds promise translational applications, predicting individuals at high-risk developing strategies intercept transformation.

Language: Английский

Citations

59