Genetic dissection of active forgetting in labile and consolidated memories in Drosophila DOI Creative Commons
Yang Gao, Yichun Shuai, Xuchen Zhang

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2019, Volume and Issue: 116(42), P. 21191 - 21197

Published: Sept. 5, 2019

Significance As a critical component of healthy memory management system, forgetting has received increasing attention. Studies across multiple species support important roles actin remodeling in forgetting. However, the underlying molecular mechanisms remain unclear. In Drosophila , Rac1 and Cdc42, 2 Rho GTPases that act as signaling hubs to coordinate remodeling, were reported mediate labile consolidated memories, respectively. Here, we showed Cdc42 exert their effects on by acting through different polymerization pathways, Rac1/SCAR/Dia Cdc42/WASp/Arp2/3 complexes. These findings fill landscape link at cellular level shed light drug development aims tune treat memory-related diseases.

Language: Английский

Non-coding RNA and memory DOI
Sarbani Samaddar, Sourav Banerjee

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Interplay between α2-chimaerin and Rac1 activity determines dynamic maintenance of long-term memory DOI Creative Commons
Li Lv, Yunlong Liu, Jianxin Xie

et al.

Nature Communications, Journal Year: 2019, Volume and Issue: 10(1)

Published: Nov. 22, 2019

Memory consolidation theory suggests that once memory formation has been completed, is maintained at a stable strength and incapable of further enhancement. However, the current study reveals even long after formation, contextual fear could be enhanced. Such unexpected enhancement possible because dynamically an intermediate level allows for bidirectional regulation. Here we find both Rac1 activation expression α2-chimaerin are stimulated by single-trial conditioning. sustained activity mediates reversible forgetting, acts as molecule reverses forgetting to sustain through inhibition during maintenance stage. Therefore, balance between activated expressed defines dynamic long-term maintenance. Our findings demonstrate consolidated maintains capacity

Language: Английский

Citations

31
Loss of Function of Phosphodiesterase 11A4 Shows that Recent and Remote Long-Term Memories Can Be Uncoupled DOI Creative Commons

Katy Pilarzyk,

Jennifer Klett,

Edsel A. Peña

et al.

Current Biology, Journal Year: 2019, Volume and Issue: 29(14), P. 2307 - 2321.e5

Published: July 1, 2019

Language: Английский

Citations

30
Not the same as it ever was: A review of memory modification, updating, and distortion in humans and rodents DOI
Chad A. Brunswick,

Chelsea Carpenter,

Nancy A. Dennis

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 106195 - 106195

Published: May 1, 2025

Language: Английский

Citations

0
Genetic dissection of active forgetting in labile and consolidated memories in Drosophila DOI Creative Commons
Yang Gao, Yichun Shuai, Xuchen Zhang

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2019, Volume and Issue: 116(42), P. 21191 - 21197

Published: Sept. 5, 2019

Significance As a critical component of healthy memory management system, forgetting has received increasing attention. Studies across multiple species support important roles actin remodeling in forgetting. However, the underlying molecular mechanisms remain unclear. In Drosophila , Rac1 and Cdc42, 2 Rho GTPases that act as signaling hubs to coordinate remodeling, were reported mediate labile consolidated memories, respectively. Here, we showed Cdc42 exert their effects on by acting through different polymerization pathways, Rac1/SCAR/Dia Cdc42/WASp/Arp2/3 complexes. These findings fill landscape link at cellular level shed light drug development aims tune treat memory-related diseases.

Language: Английский

Citations

29