The tectum/superior colliculus as the vertebrate solution for spatial sensory integration and action

Current Biology, Journal Year: 2021, Volume and Issue: 31(11), P. R741 - R762

Published: June 1, 2021

The superior colliculus, or tectum in the case of non-mammalian vertebrates, is a part brain that registers events surrounding space, often through vision and hearing, but also electrosensation, infrared detection, other sensory modalities diverse vertebrate lineages. This information used to form maps space positions different salient stimuli relation individual. are arranged layers with visual input uppermost layer, senses deeper positions, spatially aligned motor map deepest layer. Here, we will review organization intrinsic function tectum/superior colliculus processed within tectal circuits. We discuss tectal/superior outputs conveyed directly downstream circuits via thalamus cortical areas control various aspects behavior. evolutionarily conserved among all tailored specialties each lineage, its roles have shifted emergence cerebral cortex mammals. illustrate both divergent properties evolution by comparing processing lampreys belonging oldest group extant larval zebrafish, rodents, vertebrates including primates.

Language: Английский

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Development of neural circuits for social motion perception in schooling fish

Current Biology, Journal Year: 2024, Volume and Issue: 34(15), P. 3380 - 3391.e5

Published: July 17, 2024

The collective behavior of animal groups emerges from the interactions among individuals. These social produce coordinated movements bird flocks and fish schools, but little is known about their developmental emergence neurobiological foundations. By characterizing visually based schooling micro glassfish Danionella cerebrum, we found that development progresses sequentially, with animals first acquiring ability to aggregate, followed by postural alignment partners. This maturation was accompanied neural populations in midbrain were preferentially driven visual stimuli resemble shape fish. Furthermore, isolation over course impaired both encoding motion adults. work demonstrates selective for form conspecifics emerge experience-dependent movement.

Language: Английский

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Retinotectal circuitry of larval zebrafish is adapted to detection and pursuit of prey

eLife, Journal Year: 2020, Volume and Issue: 9

Published: Oct. 12, 2020

Retinal axon projections form a map of the visual environment in tectum. A zebrafish larva typically detects prey object its peripheral field. As it turns and swims towards prey, stimulus enters central, binocular area, seemingly expands size. By volumetric calcium imaging, we show that posterior tectal neurons, which serve to detect at distance, tend respond small objects intrinsically compute their direction movement. Neurons anterior tectum, where image is represented shortly before capture strike, are tuned larger sizes frequently not direction-selective, indicating mainly interocular comparisons an object’s movement close range. The feature originates from linear combination diverse, functionally specialized, lamina-specific, topographically ordered retinal ganglion cell synaptic inputs. We conclude local cell-type composition connectivity across tectum adapted processing location-dependent, behaviorally relevant features.

Language: Английский

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Conserved subcortical processing in visuo-vestibular gaze control

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Aug. 10, 2022

Abstract Gaze stabilization compensates for movements of the head or external environment to minimize image blurring. Multisensory information stabilizes scene on retina via vestibulo-ocular (VOR) and optokinetic (OKR) reflexes. While organization neuronal circuits underlying VOR is well-described across vertebrates, less known about contribution evolution OKR basic structures allowing visuo-vestibular integration. To analyze these pathways integration, we developed a setup using lamprey eye-brain-labyrinth preparation, which allowed coordinating electrophysiological recordings, vestibular stimulation with moving platform, visual screens. Lampreys exhibit robust processed in pretectum that can be downregulated from tectum. Visual inputs are integrated at several subcortical levels. Additionally, saccades present form nystagmus. Thus, all components control gaze were already dawn vertebrate evolution.

Language: Английский

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Nickel oxide nanoparticles induce developmental neurotoxicity in zebrafish by triggering both apoptosis and ferroptosis

Environmental Science Nano, Journal Year: 2023, Volume and Issue: 10(2), P. 640 - 655

Published: Jan. 1, 2023

NiO-NPs exert toxic effects on zebrafish neurobehavior and neurodevelopment through activation of apoptosis ferroptosis.

Language: Английский

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Whole-brain interactions underlying zebrafish behavior

Current Opinion in Neurobiology, Journal Year: 2020, Volume and Issue: 65, P. 88 - 99

Published: Nov. 20, 2020

Language: Английский

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Gravity-Dependent Animacy Perception in Zebrafish

Research, Journal Year: 2022, Volume and Issue: 2022

Published: Jan. 1, 2022

Biological motion (BM), depicted by a handful of point lights attached to the major joints, conveys rich animacy information, which is significantly disrupted if BM shown upside down. This well-known inversion effect in perception conserved terrestrial vertebrates and presumably manifestation an evolutionarily endowed perceptual filter (i.e., life detector) tuned gravity-compatible BM. However, it remains unknown whether aquatic animals, living completely different environment from perceive gravity-dependent manner. Here, taking advantage their typical shoaling behaviors, we used zebrafish as model animal examine ability teleosts discriminate between upright (gravity-compatible) inverted (gravity-incompatible) signals. We recorded swimming trajectories quantified preference based on dwelling time head orientation. The results obtained three experiments consistently showed that spent more proximity orienting towards relative or other gravity-incompatible point-light stimuli non-BM). More intriguingly, when video clips fish were directly compared with those human walkers pigeons, could identify unique consistent pattern movements vertical (gravity) direction. These findings, our knowledge, demonstrate for first simple suggest evolutionary origin processing may be traced back ancient animals.

Language: Английский

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A robust receptive field code for optic flow detection and decomposition during self-motion

Current Biology, Journal Year: 2022, Volume and Issue: 32(11), P. 2505 - 2516.e8

Published: May 11, 2022

Language: Английский

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Separate brainstem circuits for fast steering and slow exploratory turns

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 3, 2025

Abstract Locomotion requires precise tuning of descending commands to scale turning movements, such as rapid steering during prey pursuit or shallow turns exploration. We show that these two turn types are governed by distinct brainstem circuits. The circuit involves excitatory V2a and inhibitory commissural V0d neurons, distributed across different nuclei. These neurons coupled via gap junctions activated simultaneously, ensuring through asymmetrical activation spinal motor neurons. recruitment this correlates more with the degree direction change than locomotor frequency. Steering are, in turn, controlled a subset pretectum, salient visual input. In contrast, slow exploratory separate set confined fewer findings reveal modular organization circuits selectively control locomotion.

Language: Английский

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Effects of sodium arsenite exposure on behavior, ultrastructure and gene expression of brain in adult zebrafish (Danio rerio)

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 273, P. 116107 - 116107

Published: Feb. 20, 2024

Arsenic, a common metal-like substance, has been demonstrated to pose potential health hazards and induce behavioral changes in humans rodents. However, the chronic neurotoxic effects of arsenic on aquatic animals are still not fully understood. This study aimed investigate exposure adult zebrafish by subjecting 3-month-old three different sodium arsenite water concentrations: 0 μg/L (control group), 50 μg/L, 500 over period 30 days. To assess risk associated with environment, behavior analysis, transmission electron microscopy techniques, quantitative real-time PCR were employed. The was evaluated using six distinct tests: mirror biting test, shoaling novel tank social preference recognition T maze. Following tests, brains dissected collected for ultrastructural examination gene expression analysis. results revealed that led significant reduction aggression, cohesion, ability, cognition learning, memory capacity zebrafish. Furthermore, ultrastructure genes regulating brain adversely affected exposure.

Language: Английский

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