Scientific Reports,
Journal Year:
2021,
Volume and Issue:
11(1)
Published: April 19, 2021
Abstract
The
optokinetic
reflex
is
a
closed-loop
gaze-stabilizing
ocular
motor
reaction
that
minimizes
residual
retinal
image
slip
during
vestibulo-ocular
reflexes.
In
experimental
isolation,
the
usually
activated
by
motion
of
an
achromatic
large-field
visual
background
with
strong
influence
radiance
contrast
on
estimation
and
behavioral
performance.
presence
color
in
natural
environments,
however,
suggests
chromatic
cues
scenes
provide
additional
parameters
for
detection.
Here,
we
employed
Xenopus
laevis
tadpoles
to
study
performance
multi-unit
optic
nerve
discharge
scene.
Even
though
amplitude
decreases
smaller
contrast,
considerable
eye
movements
persist
at
‘point
equiluminance’
colored
stimuli.
Given
preferences
individual
fibers,
underlying
computation
potentially
originates
circuits.
Differential
ganglion
cell
projections
associated
signal
transformation
might
further
reinforce
dependency
conceptual
correspondence
head/body
optomotor
signaling.
Optokinetic
under
light
conditions
accordingly
influenced
as
well
composition
moving
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Oct. 27, 2023
Abstract
Many
animals
move
in
groups,
where
collective
behavior
emerges
from
the
interactions
amongst
individuals.
These
social
produce
coordinated
movements
of
bird
flocks
and
fish
schools,
but
little
is
known
about
their
developmental
emergence
neurobiological
foundations.
By
characterizing
visually-based
schooling
micro
glassfish
Danionella
cerebrum
,
here
we
found
that
development
progresses
sequentially,
with
first
acquiring
ability
to
aggregate,
followed
by
postural
alignment
partners.
This
maturation
was
accompanied
neural
populations
midbrain
forebrain
were
preferentially
driven
visual
stimuli
resemble
shape
fish.
The
these
circuits
enables
coordination
required
for
movement.
One-Sentence
Summary
selective
motion.
PLoS Genetics,
Journal Year:
2024,
Volume and Issue:
20(4), P. e1011139 - e1011139
Published: April 26, 2024
As
essential
components
of
gene
expression
networks,
transcription
factors
regulate
neural
circuit
assembly.
The
homeobox
factor
encoding
gene,
gs
1
(gsx1),
is
expressed
in
the
developing
visual
system;
however,
no
studies
have
examined
its
role
system
formation.
In
zebrafish,
retinal
ganglion
cell
(RGC)
axons
that
transmit
information
to
brain
terminate
ten
arborization
fields
(AFs)
optic
tectum
(TeO),
pretectum
(Pr),
and
thalamus.
Pretectal
AFs
(AF1-AF9)
mediate
distinct
behaviors,
yet
we
understand
less
about
their
development
compared
AF10
TeO.
Using
gsx1
zebrafish
mutants,
immunohistochemistry,
transgenic
lines,
observed
required
for
vesicular
glutamate
transporter,
Tg(slc17a6b:DsRed),
Pr,
but
not
overall
neuron
number.
mutants
normal
eye
morphology,
they
exhibit
impaired
ability
during
prey
capture.
RGC
axon
volume
mutant
Pr
TeO
reduced,
AF7
active
feeding
missing
which
consistent
with
reduced
hunting
performance.
Timed
laser
ablation
Tg(slc17a6b:DsRed)-positive
cells
reveals
are
necessary
This
work
first
implicate
establishing
identity
functional
circuits
system.
Investigative Ophthalmology & Visual Science,
Journal Year:
2019,
Volume and Issue:
60(14), P. 4681 - 4681
Published: Nov. 14, 2019
Purpose:
To
compare
the
effects
of
reduced
inhibitory
neuron
function
in
retina
across
behavioral,
physiological,
and
anatomical
levels.
Methods:
Inhibitory
neurons
were
ablated
larval
zebrafish
retina.
The
Ptf1a
gene,
which
determines
fate
developing
vertebrates,
was
used
to
express
nitroreductase.
By
exposing
larvae
prodrug
metronidazole,
cytotoxicity
selectively
induced
neurons.
Visual
phenotypes
characterized
at
levels
using
an
optomotor
response
(OMR)
assay,
electroretinography
(ERG),
routine
histology,
respectively.
Nonvisual
locomotion
also
assessed
reveal
any
general
behavioral
due
ablation
other
nonvisual
that
Ptf1a.
Results:
Injured
showed
severely
OMR
relative
controls.
Locomotor
assessment
unaltered
swimming
ability,
indicating
visual
deficits.
For
ERG,
injured
manifested
either
(type-I)
or
absent
(type-II)
b-wave
signals
originating
from
bipolar
interneurons
Histologic
analysis
altered
retinal
morphology
larvae,
with
reductions
synaptic
inner
plexiform
layer
(IPL)
thickness
density
more
pronounced
type-II
than
type-I
larvae;
had
smaller
retinae
overall.
Conclusions:
consequences
corresponded
closely
loss
likely
increases
ratio
neural
excitation
inhibition,
leading
hyperexcitability.
In
addition
modulating
signals,
may
be
critical
for
maintaining
structure
organization.
This
study
highlights
utility
a
multidisciplinary
approach
provides
template
characterizing
models
neurological
disease.
Scientific Reports,
Journal Year:
2021,
Volume and Issue:
11(1)
Published: April 19, 2021
Abstract
The
optokinetic
reflex
is
a
closed-loop
gaze-stabilizing
ocular
motor
reaction
that
minimizes
residual
retinal
image
slip
during
vestibulo-ocular
reflexes.
In
experimental
isolation,
the
usually
activated
by
motion
of
an
achromatic
large-field
visual
background
with
strong
influence
radiance
contrast
on
estimation
and
behavioral
performance.
presence
color
in
natural
environments,
however,
suggests
chromatic
cues
scenes
provide
additional
parameters
for
detection.
Here,
we
employed
Xenopus
laevis
tadpoles
to
study
performance
multi-unit
optic
nerve
discharge
scene.
Even
though
amplitude
decreases
smaller
contrast,
considerable
eye
movements
persist
at
‘point
equiluminance’
colored
stimuli.
Given
preferences
individual
fibers,
underlying
computation
potentially
originates
circuits.
Differential
ganglion
cell
projections
associated
signal
transformation
might
further
reinforce
dependency
conceptual
correspondence
head/body
optomotor
signaling.
Optokinetic
under
light
conditions
accordingly
influenced
as
well
composition
moving
