Reduced emergent character of neural dynamics in patients with a disrupted connectome DOI Creative Commons
Andrea I. Luppi, Pedro A. M. Mediano, Fernando Rosas

et al.

NeuroImage, Journal Year: 2023, Volume and Issue: 269, P. 119926 - 119926

Published: Feb. 3, 2023

High-level brain functions are widely believed to emerge from the orchestrated activity of multiple neural systems. However, lacking a formal definition and practical quantification emergence for experimental data, neuroscientists have been unable empirically test this long-standing conjecture. Here we investigate fundamental question by leveraging recently proposed framework known as "Integrated Information Decomposition," which establishes principled information-theoretic approach operationalise quantify in dynamical systems - including human brain. By analysing functional MRI our results show that emergent hierarchical character dynamics is significantly diminished chronically unresponsive patients suffering severe injury. At level, demonstrate capacity positively correlated with extent organisation activity. Furthermore, combining computational approaches network control theory whole-brain biophysical modelling, reduced severely brain-injured can be mechanistically explained disruptions patients' structural connectome. Overall, suggest chronic unresponsiveness resulting injury may related impairment infrastructures required support emergence.

Language: Английский

Music in the brain DOI
Peter Vuust, Ole Adrian Heggli, Karl Friston

et al.

Nature reviews. Neuroscience, Journal Year: 2022, Volume and Issue: 23(5), P. 287 - 305

Published: March 29, 2022

Language: Английский

Citations

229
Consciousness and complexity: a consilience of evidence DOI Creative Commons
Simone Sarasso, Adenauer G. Casali, Silvia Casarotto

et al.

Neuroscience of Consciousness, Journal Year: 2021, Volume and Issue: 2021(2)

Published: Jan. 1, 2021

Over the last years, a surge of empirical studies converged on complexity-related measures as reliable markers consciousness across many different conditions, such sleep, anesthesia, hallucinatory states, coma, and related disorders. Most these were independently proposed by researchers endorsing disparate frameworks employing methods techniques. Since this body evidence has not been systematically reviewed coherently organized so far, positive trend remained somewhat below radar. The aim paper is to make consilience in science explicit. We start with systematic assessment growing literature identify their common denominator, tracing it back core theoretical principles predictions put forward more than 20 years ago. In doing this, we highlight consistent trajectory spanning two decades research provide provisional taxonomy present literature. Finally, consider all above ground approach new questions devise future experiments that may help consolidate further develop promising field where appears have, naturally converged.

Language: Английский

Citations

128
Revisiting the global workspace orchestrating the hierarchical organization of the human brain DOI Creative Commons
Gustavo Deco, Diego Vidaurre, Morten L. Kringelbach

et al.

Nature Human Behaviour, Journal Year: 2021, Volume and Issue: 5(4), P. 497 - 511

Published: Jan. 4, 2021

Abstract A central challenge in neuroscience is how the brain organizes information necessary to orchestrate behaviour. Arguably, this whole-brain orchestration carried out by a core subset of integrative regions, ‘global workspace’, but its constitutive regions remain unclear. We quantified global workspace as common across seven tasks well rest, ‘functional rich club’. To identify functional club, we determined flow between means normalized directed transfer entropy framework applied multimodal neuroimaging data from 1,003 healthy participants and validated with retest data. This revealed set orchestrating perceptual, long-term memory, evaluative attentional systems. confirmed causal significance robustness our results systematically lesioning generative model. Overall, describes complex choreography hierarchical organization human brain.

Language: Английский

Citations

122
Receptor-informed network control theory links LSD and psilocybin to a flattening of the brain’s control energy landscape DOI Creative Commons
S. Parker Singleton, Andrea I. Luppi,

Robin Carhart‐Harris

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Oct. 3, 2022

Psychedelics including lysergic acid diethylamide (LSD) and psilocybin temporarily alter subjective experience through their neurochemical effects. Serotonin 2a (5-HT2a) receptor agonism by these compounds is associated with more diverse (entropic) brain activity. We postulate that this increase in entropy may arise part from a flattening of the brain's control energy landscape, which can be observed using network theory to quantify required transition between recurrent states. Using states derived existing functional magnetic resonance imaging (fMRI) datasets, we show LSD reduce for state transitions compared placebo. Furthermore, across individuals, reduction correlates frequent increased dynamics. Through analysis incorporates spatial distribution 5-HT2a receptors (obtained publicly available positron emission tomography (PET) data under non-drug conditions), demonstrate an association reduced energy. Our findings provide evidence agonist allow facile temporally More broadly, receptor-informed model impact neuropharmacological manipulation on activity

Language: Английский

Citations

95
The human orbitofrontal cortex, vmPFC, and anterior cingulate cortex effective connectome: emotion, memory, and action DOI
Edmund T. Rolls, Gustavo Deco, Chu‐Chung Huang

et al.

Cerebral Cortex, Journal Year: 2022, Volume and Issue: 33(2), P. 330 - 356

Published: Feb. 4, 2022

The human orbitofrontal cortex, ventromedial prefrontal cortex (vmPFC), and anterior cingulate are involved in reward processing thereby emotion but also implicated episodic memory. To understand these regions better, the effective connectivity between 360 cortical 24 subcortical was measured 172 humans from Human Connectome Project complemented with functional diffusion tractography. has gustatory, olfactory, temporal visual, auditory, pole areas. to pregenual posterior hippocampal system provides for rewards be used memory navigation goals. have supracallosal which projects midcingulate other premotor areas action-outcome learning including limb withdrawal or flight fight aversive nonreward stimuli. lateral outputs language systems inferior frontal gyrus. medial connects nucleus basalis of Meynert septum, damage may contribute impairments by disrupting cholinergic influences on neocortex hippocampus.

Language: Английский

Citations

89
Distributed harmonic patterns of structure-function dependence orchestrate human consciousness DOI Creative Commons
Andrea I. Luppi, Jakub Vohryzek, Morten L. Kringelbach

et al.

Communications Biology, Journal Year: 2023, Volume and Issue: 6(1)

Published: Jan. 28, 2023

Abstract A central question in neuroscience is how consciousness arises from the dynamic interplay of brain structure and function. Here we decompose functional MRI signals pathological pharmacologically-induced perturbations into distributed patterns structure-function dependence across scales: harmonic modes human structural connectome. We show that coupling a generalisable indicator under bi-directional neuromodulatory control. find increased scales during loss consciousness, whether due to anaesthesia or injury, capable discriminating between behaviourally indistinguishable sub-categories brain-injured patients, tracking presence covert consciousness. The opposite signature characterises altered state induced by LSD ketamine, reflecting psychedelic-induced decoupling function correlating with physiological subjective scores. Overall, connectome decomposition reveals neuromodulation network architecture jointly shape activation scales.

Language: Английский

Citations

69
Information decomposition and the informational architecture of the brain DOI Creative Commons
Andrea I. Luppi, Fernando Rosas, Pedro A. M. Mediano

et al.

Trends in Cognitive Sciences, Journal Year: 2024, Volume and Issue: 28(4), P. 352 - 368

Published: Jan. 9, 2024

To explain how the brain orchestrates information-processing for cognition, we must understand information itself. Importantly, is not a monolithic entity. Information decomposition techniques provide way to split into its constituent elements: unique, redundant, and synergistic information. We review disentangling redundant interactions redefining our understanding of integrative function neural organisation. navigates trade-offs between redundancy synergy, converging evidence integrating structural, molecular, functional underpinnings synergy redundancy; their roles in cognition computation; they might arise over evolution development. Overall, provides guiding principle informational architecture cognition.

Language: Английский

Citations

62
Toward naturalistic neuroscience: Mechanisms underlying the flattening of brain hierarchy in movie-watching compared to rest and task DOI Creative Commons
Morten L. Kringelbach, Yonatan Sanz Perl, Enzo Tagliazucchi

et al.

Science Advances, Journal Year: 2023, Volume and Issue: 9(2)

Published: Jan. 13, 2023

Identifying the functional specialization of brain has moved from using cognitive tasks and resting state to ecological relevant, naturalistic movies. We leveraged a large-scale neuroimaging dataset directly investigate hierarchical reorganization activity when watching films compared performing seven resting. A thermodynamics-inspired whole-brain model paradigm revealed generative underlying mechanisms for changing balance in causal interactions between regions different conditions. Paradoxically, hierarchy is flatter movie-watching, level nonreversibility significantly smaller comparison both rest tasks, where latter turn have highest levels nonreversibility. The were by model-based effective connectivity (GEC). Naturalistic could therefore provide fast convenient way measure important changes GEC (integrating anatomical connectivity) found in, example, neuropsychiatric disorders. Overall, this study demonstrates benefits moving toward more neuroscience.

Language: Английский

Citations

60
Virtual brain twins: from basic neuroscience to clinical use DOI Creative Commons
Huifang Wang, Paul Triebkorn, Martin Breyton

et al.

National Science Review, Journal Year: 2024, Volume and Issue: 11(5)

Published: Feb. 27, 2024

ABSTRACT Virtual brain twins are personalized, generative and adaptive models based on data from an individual’s for scientific clinical use. After a description of the key elements virtual twins, we present standard model personalized whole-brain network models. The personalization is accomplished using subject’s imaging by three means: (1) assemble cortical subcortical areas in subject-specific space; (2) directly map connectivity into models, which can be generalized to other parameters; (3) estimate relevant parameters through inversion, typically probabilistic machine learning. We use healthy ageing five diseases: epilepsy, Alzheimer’s disease, multiple sclerosis, Parkinson’s disease psychiatric disorders. Specifically, introduce spatial masks demonstrate their physiological pathophysiological hypotheses. Finally, pinpoint challenges future directions.

Language: Английский

Citations

26
Innovation at the Intersection: Emerging Translational Research in Neurology and Psychiatry DOI Creative Commons
Masaru Tanaka, Simone Battaglia, Lydia Giménez‐Llort

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(10), P. 790 - 790

Published: May 7, 2024

Translational research in neurological and psychiatric diseases is a rapidly advancing field that promises to redefine our approach these complex conditions [...]

Language: Английский

Citations

19