Movement-independent representation of reward-predicting cues in the medial part of the primate premotor cortex DOI Creative Commons
Keisuke Sehara, Masashi Kondo,

Yuka Hirayama

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 26, 2024

Abstract Neural activity across the dorsal neocortex of rodents is dominated by orofacial and limb movements, irrespective whether movements are task-relevant or task-irrelevant. To examine extent to which a primitive cognitive signal, i.e., reward expectancy, modulate multiple cortical areas in primates, we conducted unprecedented wide-field one-photon calcium imaging frontoparietal auditory cortices common marmosets while they performed classical conditioning task with two cues associated different probabilities. Licking, eye movement, hand movement strongly modulated neuronal after cue presentation motor somatosensory accordance somatotopy. By contrast, posterior parietal cortex primary did not show much influence from licking. Licking increased caudal part premotor cortex, but decreased central lateral parts rostral (PMdr). Reward expectancy that was separable both spontaneous goal-directed mainly represented medial PMdr. Our results suggest on primate varies types, processes information ways within further subdivided areas.

Language: Английский

Optogenetic inhibition quenches the integration of sensory input in the cortex DOI Open Access

Ambrosone Manuel,

Elena Montagni, Francesco Resta

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

ABSTRACT Significance Many fundamental processes of brain computation, such as sensory perception and motor control, heavily rely on the mesoscopic dynamics activity across cerebral cortex. Manipulating mesoscale observing its effects multiple regions is crucial for understanding causal link between cortical behavior. Objective The goal this study was to develop a novel all-optical system that allows inhibition excitatory neurons while simultaneously monitoring responses at arbitrary sites entire dorsal cortex mice. Methods We combined wide-field imaging optogenetics create approach, enabling simultaneous manipulation using light. Intravenous injection two PHP.eB AAVs enabled whole-brain co-expression red-shifted calcium indicator jRCaMP1b inhibitory actuator stGtACR2, with stable expression over several weeks. This calibrated, were tested. Results Increasing laser power progressively reduced spontaneous site irradiation. A single 5-second pulse barrel field significantly decreased amplitude sensory-evoked responses, not only in stimulated region but hemisphere. Conclusions enables targeted concurrently activity. It provides insights into circuits offers milestone investigating links neuronal Future research can use tool address responsiveness impairments neurological neuropsychiatric disorders.

Language: Английский

Citations

0
Dynamics of motor direction representation in the primate premotor and primary motor cortices during sensorimotor learning DOI Creative Commons
Teppei Ebina,

Akitaka Sasagawa,

D. Hong

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 14, 2023

Summary Sensorimotor learning requires reorganization of neuronal activity in the premotor cortex (PM) and primary motor (M1). However, how PM- M1-specific occurs primates remains unclear. We conducted calcium imaging these areas common marmosets while they learned a two-target reaching (pull/push) task. Throughout learning, dorsorostral PM (PMdr) showed peak earlier than dorsocaudal (PMdc) M1. PMdr decreased representation newly introduced (push) movement, whereas PMdc M1 maintained high representation. Many task-related neurons exhibited strong preference to either movement direction. dynamically switched their preferred direction, stably retained Differences direction between adjacent increased during learning. These results suggest that primate sensorimotor dynamic converts cognitive signals stable specific

Language: Английский

Citations

1
Mouse frontal cortex nonlinearly encodes stimuli, choices, and outcomes DOI Creative Commons
Lauren E Wool, Armin Lak, Matteo Carandini

et al.

Wellcome Open Research, Journal Year: 2023, Volume and Issue: 8, P. 451 - 451

Published: Oct. 12, 2023

Frontal area MOs (secondary motor area) is a key brain structure in rodents for making decisions based on sensory evidence and reward value. Its neurons can encode stimuli, upcoming choices, expected rewards, ongoing actions, recent outcomes. However, the information encoded, nature of resulting code, may depend task being performed. We recorded population activity using two-photon calcium imaging, requiring mice to integrate with Mice turned wheel report location visual stimulus following delay period, receive whose size varied over trial blocks. encoded multiple variables, but not all those seen other tasks. In strongly side did significantly reward-size block. A correlation choice could be explained by common effect stimuli two correlates. After turn feedback, outcome jointly nonlinearly according an exclusive-or (XOR) operation. This nonlinear operation would allow downstream linear decoder infer correct (i.e., that have been rewarded) even zero contrast trials, when there had no visible stimulus. These results indicate flexibly some variables determine behavior, depending task. Moreover, they reveal reflect combination these behavioral allowing simple inference events directly observable.

Language: Английский

Citations

1
Medial prefrontal cortex suppresses reward-seeking behavior with risk of positive punishment by reducing sensitivity to reward DOI Creative Commons
Monami Nishio, Masashi Kondo,

Eriko Yoshida

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 3, 2024

Abstract Reward-seeking behavior is frequently associated with risk of punishment. There are two types punishment: positive, resulting in an unpleasant outcome, and negative, omission a reinforcing outcome. Although the medial prefrontal cortex (mPFC) important avoiding punishment, whether it for both positive negative punishment how contributes to such avoidance not clear. In this study, we trained male mice perform decision-making tasks under risks (air-puff stimulus) (reward omission) We found that pharmacological inactivation mPFC enhanced reward-seeking choice but reinforcement learning models, behavioral change was well-explained by hypersensitivity reward, rather than decrease strength aversion Our results suggest suppresses reducing sensitivity reward

Language: Английский

Citations

0
Movement-independent representation of reward-predicting cues in the medial part of the primate premotor cortex DOI Creative Commons
Keisuke Sehara, Masashi Kondo,

Yuka Hirayama

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 26, 2024

Abstract Neural activity across the dorsal neocortex of rodents is dominated by orofacial and limb movements, irrespective whether movements are task-relevant or task-irrelevant. To examine extent to which a primitive cognitive signal, i.e., reward expectancy, modulate multiple cortical areas in primates, we conducted unprecedented wide-field one-photon calcium imaging frontoparietal auditory cortices common marmosets while they performed classical conditioning task with two cues associated different probabilities. Licking, eye movement, hand movement strongly modulated neuronal after cue presentation motor somatosensory accordance somatotopy. By contrast, posterior parietal cortex primary did not show much influence from licking. Licking increased caudal part premotor cortex, but decreased central lateral parts rostral (PMdr). Reward expectancy that was separable both spontaneous goal-directed mainly represented medial PMdr. Our results suggest on primate varies types, processes information ways within further subdivided areas.

Language: Английский

Citations

0