Springer eBooks, Journal Year: 2022, Volume and Issue: unknown, P. 575 - 598
Published: Jan. 1, 2022
Language: Английский
Biological Psychiatry, Journal Year: 2022, Volume and Issue: 93(2), P. 197 - 208
Published: June 22, 2022
Language: Английский
Citations
16
Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 155, P. 105475 - 105475
Published: Nov. 22, 2023
The brain is a remarkably complex organ responsible for wide range of functions, including the modulation emotional states and movement. Neuronal circuits are believed to play crucial role in integrating sensory, cognitive, information ultimately guide motor behavior. Over years, numerous studies employing diverse techniques such as electrophysiology, imaging, optogenetics have revealed network neural involved regulation or processes. Emotions can exert substantial influence on performance, encompassing both everyday activities pathological conditions. aim this review explore how shape movements by connecting processing circuits. We first provide comprehensive overview impact different control humans rodents. In line with behavioral studies, we set out identify emotion-related structures capable modulating output, behaviorally anatomically. extensively connected system. These drive behavior, essential survival, but also continuously ongoing summary, investigation intricate relationship between emotion movement offers valuable insights into human opportunities enhance holds promise improving mental physical health. This integrates findings from multiple scientific approaches, anatomical tracing, circuit-based dissection, conducted animal subjects. By incorporating these methodologies, present current understanding physiological
Language: Английский
Citations
8
Journal of Neurochemistry, Journal Year: 2024, Volume and Issue: 168(3), P. 251 - 268
Published: Feb. 3, 2024
Abstract The striatum can be divided into four anatomically and functionally distinct domains: the dorsolateral, dorsomedial, ventral more recently identified caudolateral (tail) striatum. Dopamine transmission in these striatal domains underlies many important behaviours, yet little is known about this phenomenon tail Furthermore, divisions (dorsal, medial, intermediate lateral) based on profile of D 1 2 dopamine receptor‐expressing medium spiny neurons, something that not seen elsewhere Considering organisation, how occurs great interest. We recorded evoked release divisions, with comparison to dorsolateral striatum, using fast‐scan cyclic voltammetry rat brain slices. Contributions clearance mechanisms were investigated transporter knockout (DAT‐KO) rats, pharmacological inhibitors dextran. Evoked all was smaller amplitude than and, importantly, regional variation observed: ≈ lateral > medial dorsal intermediate. Release amplitudes division 300% division, which also exhibited uniquely slow peak velocity. most dependent DAT, no alternative transporters (organic cation transporter‐3, norepinephrine serotonin transporter) contributed significantly any division. Our findings confirm only a domain but each has unique characteristics. This supports are distinct. How segregation relates overall function particularly processing multisensory information, determined. image
Language: Английский
Citations
3
Journal of Neuroscience, Journal Year: 2022, Volume and Issue: 42(35), P. 6668 - 6679
Published: July 29, 2022
Dopamine (DA) is a critical regulator of striatal network activity and essential for motor activation reward-associated behaviors. Previous work has shown that DA influenced by the reward value food, as well hormonal factors reguate food intake energy expenditure. Changes in signaling also have been linked to aberrant eating patterns. Here we test effect leptin, an adipocyte-derived hormone involved feeding homeostasis regulation, on release uptake. Immunohistochemical evaluation identified leptin receptor (LepR) expression throughout mouse striatum, including cholinergic interneurons (ChIs) their extensive processes. Using fast-scan cyclic voltammetry (FSCV), found causes concentration-dependent increase evoked extra-cellular concentration ([DA]o) dorsal striatum (dStr) nucleus accumbens (NAc) core shell male slices, rate Further, increases ChI excitability, enhancing [DA]o lost when nicotinic acetylcholine (ACh) receptors are antagonized or examined slices from mice lacking ACh synthesis. Evaluation pathways underlying leptin9s action revealed requirement intracellular Ca2+, involvement different downstream dStr NAc versus shell. These results provide first evidence dynamic regulation uptake within brain pathways, highlight ChIs this process. SIGNIFICANCE STATEMENT Given importance dopamine reward, motivation, behavior intake, identifying actions metabolic hormones subregions should new insight into influence DA-dependent motivated We find one these hormones, boosts through process involving receptors. Moreover, cascades lead enhanced differ among subregions. Thus, not only show regulates release, but identify characteristics could be harnessed alter pathologic
Language: Английский
Citations
12
Cell Reports, Journal Year: 2022, Volume and Issue: 42(1), P. 111915 - 111915
Published: Dec. 30, 2022
Modes of somatodendritic transmission range from rapid synaptic signaling to protracted regulation over distance. Somatodendritic dopamine secretion in the midbrain leads D2 receptor-induced modulation neurons on timescale seconds. Temporally imprecise release mechanisms are often presumed be at play, and previous work indeed suggested roles for slow Ca2+ sensors. We here use mouse genetics whole-cell electrophysiology establish that fast sensor synaptotagmin-1 (Syt-1) is important release. Syt-1 ablation strongly reduces stimulus-evoked receptor-mediated inhibitory postsynaptic currents (D2-IPSCs) midbrain. D2-IPSCs evoked by paired stimuli exhibit less depression, high-frequency trains restore Spontaneous independent Syt-1, supporting its exocytotic differ conclude relies leading synchronous response initial stimulus.
Language: Английский
Citations
12
Journal of Neuroscience, Journal Year: 2022, Volume and Issue: 42(32), P. 6186 - 6194
Published: July 6, 2022
Midbrain dopamine neurons play central physiological roles in voluntary movement, reward learning, and motivated behavior. Inhibitory signaling at somatodendritic D2 receptor (D2R) synapses modulates excitability of neurons. The neuropeptide neurotensin is expressed by many inputs to the midbrain induces LTD D2R synaptic currents (LTDDA); however, source that responsible for LTDDA not known. Here we show, brain slices from male female mice, driven released themselves. Optogenetic stimulation was sufficient induce substantia nigra, but VTA, dependent on signaling, postsynaptic calcium, vacuolar-type H+-ATPase activity cell. These findings reveal a novel form between involving release peptide neurotensin, which may act as feedforward mechanism increase neuron excitability. SIGNIFICANCE STATEMENT Dopamine critical role learning initiation movement. Aberrant function implicated range diseases disorders, including Parkinson9s disease, schizophrenia, obesity, substance use disorders. receptor-mediated PSCs are produced rare dendrodendritic transmission undergo following application neurotensin. show themselves nigra. Neurotensin therefore mediates second interdopamine communication provide maintain when nigral elevated.
Language: Английский
Citations
10
Journal of the Neurological Sciences, Journal Year: 2023, Volume and Issue: 453, P. 120809 - 120809
Published: Sept. 23, 2023
Language: Английский
Citations
6
Cell Reports, Journal Year: 2022, Volume and Issue: 40(7), P. 111199 - 111199
Published: Aug. 1, 2022
The norepinephrine neurons in locus coeruleus (LC-NE neurons) are essential for sleep arousal, pain sensation, and cocaine addiction. According to previous studies, increases NE overflow (the profile of extracellular level response stimulation) by blocking the reuptake. is determined release via exocytosis reuptake through transporter (NET). However, whether directly affects vesicular has not been tested. By recording quantal from LC-NE neurons, we report that frequency regulation NET downstream protein kinase C (PKC) signaling, this facilitation modulates activity cocaine-induced stimulant behavior. Thus, these findings expand repertoire mechanisms underlying effects on (pro-release anti-reuptake), demonstrate as a enhancer provide potential sites treatment
Language: Английский
Citations
9
Heliyon, Journal Year: 2024, Volume and Issue: 10(12), P. e33158 - e33158
Published: June 1, 2024
Nicotine, the main compound in cigarettes, leads to smoking addiction. Nicotine acts on limbic dopamine reward loop midbrain by binding nicotinic acetylcholine receptors, promoting release of dopamine, and resulting a rewarding effect or satisfaction. This satisfaction is essential for continued compulsive tobacco use, therefore plays crucial role nicotine dependence. Numerous studies have identified genetic polymorphisms dopaminergic pathways which may influence susceptibility Dopamine levels are greatly influenced synthesis, storage, release, degradation, reuptake-related genes, including genes encoding tyrosine hydroxylase, decarboxylase, transporter, receptor, 3-hydroxylase, catechol-O-methyltransferase, monoamine oxidase. In this paper, we review research progress effects above downstream behavior dependence, offer theoretical basis elucidation mechanism underlying dependence future personalized treatment cessation.
Language: Английский
Citations
1
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2021, Volume and Issue: unknown
Published: Sept. 16, 2021
Abstract In Parkinson’s disease (PD), motor dysfunctions only become apparent after extensive loss of DA innervation. This resilience has been hypothesized to be due the ability many behaviors sustained through a diffuse basal tone DA; but experimental evidence for this is limited. Here we show that conditional deletion calcium sensor synaptotagmin-1 (Syt1) in neurons (Syt1 cKO mice) abrogates most activity-dependent axonal release striatum and mesencephalon, leaving somatodendritic (STD) intact. Strikingly, Syt1 mice showed intact performance multiple unconditioned DA-dependent tasks even task evaluating conditioned motivation food. Considering extracellular levels were unchanged, our findings suggest dispensable such they can by DA. Taken together, reveal striking functions context near-abolition phasic release, shedding new light on why innervation required PD.
Language: Английский
Citations
10