Divergent Visuomotor Strategies in Teleosts: Neural Circuit Mechanisms in Zebrafish and Danionella cerebrum DOI Open Access
Kaitlyn E. Fouke, Zichen He, Matthew D. Loring

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 23, 2024

Abstract Many animals respond to sensory cues with species-specific coordinated movements successfully navigate their environment. However, the neural mechanisms that support diverse sensorimotor transformations across species distinct navigational strategies remain largely unexplored. By comparing related teleost species, zebrafish ( Danio rerio, ZF ) and Danionella cerebrum DC ), we investigated behavioral patterns architectures during visually guided optomotor response (OMR). Closed-loop tracking visual stimulation revealed larval employ burst-and-glide locomotion, while display continuous, smooth swimming punctuated sharp directional turns. Although achieve higher average speeds, they lack direction-dependent velocity modulation observed in . Whole-brain two-photon calcium imaging tail head-fixed fish reveals both exhibit direction-selective motion encoding homologous regions, including retinorecipient pretectum, exhibiting fewer binocular, neurons overall. Kinematic analysis of behavior sustain significantly longer directed swim events all stimuli than , highlighting divergent visuomotor strategies, reducing movement duration oblique, turn-inducing stimuli. Lateralized motor-associated activity medial anterior hindbrain suggests a shared circuit motif, circuits independently control vigor direction. These findings highlight diversity among underscored by motifs, establish robust framework for unraveling driving continuous discrete paving way deeper insights into vertebrate functions. Research Highlights Larval faster matching direction motion. execute OMR smooth, curved patterns, interspersed share similar architecture, recruiting pretectal regions. demonstrate lateralized turns, particularly neurons. In Brief global low-angle consistently zebrafish. Fouke et al. use freely moving head fixed reveal an evolutionarily conserved architecture transforming locomotor behaviors. Graphical

Language: Английский

Development of neural circuits for social motion perception in schooling fish DOI Creative Commons
David Zada, Lisanne Schulze, Jo‐Hsien Yu

et al.

Current Biology, Journal Year: 2024, Volume and Issue: 34(15), P. 3380 - 3391.e5

Published: July 17, 2024

The collective behavior of animal groups emerges from the interactions among individuals. These social produce coordinated movements bird flocks and fish schools, but little is known about their developmental emergence neurobiological foundations. By characterizing visually based schooling micro glassfish Danionella cerebrum, we found that development progresses sequentially, with animals first acquiring ability to aggregate, followed by postural alignment partners. This maturation was accompanied neural populations in midbrain were preferentially driven visual stimuli resemble shape fish. Furthermore, isolation over course impaired both encoding motion adults. work demonstrates selective for form conspecifics emerge experience-dependent movement.

Language: Английский

Citations

12
Ultrafast sound production mechanism in one of the smallest vertebrates DOI Creative Commons
V. A. Cook, Antonia H. Groneberg, Maximilian Hoffmann

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(10)

Published: Feb. 26, 2024

Motion is the basis of nearly all animal behavior. Evolution has led to some extraordinary specializations propulsion mechanisms among invertebrates, including mandibles dracula ant and claw pistol shrimp. In contrast, vertebrate skeletal movement considered be limited by speed muscle, saturating around 250 Hz. Here, we describe unique mechanism which

Language: Английский

Citations

9
Embryonic exposure of estrogen and BPA in zebrafish leads to ADHD-like and ASD-like phenotypes, respectively DOI

Qiaosen Shen,

Feng Zhao, Na Zhang

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 111293 - 111293

Published: Feb. 1, 2025

Language: Английский

Citations

1
The mesencephalic locomotor region recruits V2a reticulospinal neurons to drive forward locomotion in larval zebrafish DOI Creative Commons
Martin Carbó-Tano, Mathilde Lapoix, Xinyu Jia

et al.

Nature Neuroscience, Journal Year: 2023, Volume and Issue: 26(10), P. 1775 - 1790

Published: Sept. 4, 2023

Abstract The mesencephalic locomotor region (MLR) is a brain stem area whose stimulation triggers graded forward locomotion. How MLR neurons recruit downstream vsx2 + (V2a) reticulospinal (RSNs) poorly understood. Here, to overcome this challenge, we uncovered the locus of in transparent larval zebrafish and show that distinct from nucleus medial longitudinal fasciculus. stimulations reliably elicit locomotion controlled duration frequency. V2a RSNs via projections onto somata pontine retropontine areas, dendrites medulla. High-speed volumetric imaging neuronal activity reveals strongly MLR-coupled are active for steering or swimming, whereas weakly medullary encode frequency component. Our study demonstrates how specific control kinematics suggests conservation motor functions across vertebrates.

Language: Английский

Citations

20
The mechanism for directional hearing in fish DOI Creative Commons
Johannes Veith, Thomas Chaigne,

Ana Svanidze

et al.

Nature, Journal Year: 2024, Volume and Issue: 631(8019), P. 118 - 124

Published: June 19, 2024

Abstract Locating sound sources such as prey or predators is critical for survival in many vertebrates. Terrestrial vertebrates locate by measuring the time delay and intensity difference of pressure at each ear 1–5 . Underwater, however, physics makes interaural cues very small, suggesting that directional hearing fish should be nearly impossible 6 Yet, has been confirmed behaviourally, although mechanisms have remained unknown decades. Several hypotheses proposed to explain this remarkable ability, including possibility evolved an extreme sensitivity minute differences might compare with particle motion signals 7,8 However, experimental challenges long hindered a definitive explanation. Here we empirically test these models transparent teleost Danionella cerebrum , one smallest 9,10 By selectively controlling motion, dissect sensory algorithm underlying acoustic startles. We find both are indispensable behaviour their relative phase controls its direction. Using micro-computed tomography optical vibrometry, further show D. structures implement mechanism. shares more than 15% living vertebrate species, widespread mechanism inferring

Language: Английский

Citations

6
Diverse prey capture strategies in teleost larvae DOI Open Access
Duncan S Mearns,

Sydney A Hunt,

Martin Schneider

et al.

Published: Feb. 10, 2025

Animal behavior is adapted to the sensory environment in which it evolved, while also being constrained by physical limits, evolutionary history, and developmental trajectories. The hunting of larval zebrafish ( Danio rerio ), a cyprinid native streams Eastern India, has been well characterized. However, unknown if complement sequence movements employed during prey capture universal across freshwater teleosts. Here, we explore syntax fish belonging clade Percomorpha , whose last common ancestor with cyprinids lived ∼240 million years ago. We compared four cichlid species from Lake Tanganyika endemic deep benthic parts lake Lepidiolamprologus attenuatus Lamprologus ocellatus Neolamprologus multifasciatus ) or inhabiting rivers Astatotilapia burtoni that medaka Oryzias latipes found rice paddies East Asia. Using high speed videography neural networks, tracked eye extracted swim kinematics larvae these five species. Notably, repertoire cichlids broader than zebrafish, but shares basic features, such as convergence, positioning centrally binocular visual field, discrete bouts, including two kinds strikes. In contrast, continuously, track monocularly without position laterally before capturing them side swing. This configuration kinematic motifs suggests may judge distance predominantly motion parallax, mainly use cues. Together, our study documents diversification locomotor oculomotor adaptations among teleost larvae.

Language: Английский

Citations

0
Label‐Free Multiphoton Imaging Reveals Volumetric Shifts Across Development in Sensory‐Related Brain Regions of a Miniature Transparent Vertebrate DOI
Rose L. Tatarsky, Najva Akbari, Ke Wang

et al.

The Journal of Comparative Neurology, Journal Year: 2025, Volume and Issue: 533(4)

Published: April 1, 2025

ABSTRACT Animals integrate information from different sensory modalities as they mature and perform increasingly complex behaviors. This may parallel differential investment in specific brain regions depending on the changing demands of inputs. To investigate developmental changes volume canonical regions, we used third harmonic generation imaging for morphometric analysis forebrain midbrain larval through juvenile adult stages Danionella dracula , a transparent, miniature teleost fish whose is optically accessible throughout its lifespan. Relative to whole‐brain volume, increased or telencephalon, higher order integration center, shows most dramatic increases between 30–60 days postfertilization (dpf) again at 90 dpf animals reach adulthood. The torus longitudinalis (TL), visuomotor also significantly 60 dpf. In contrast, optic tectum (TeO), retinal‐recipient target, progressively decreases 30 dpf, whereas relatively consistent across all semicircularis (TS), secondary auditory mechanosensory lateral line olfactory bulb (OB), direct target epithelium. sum, higher‐order centers (telencephalon, TL) occurs juveniles adulthood (60–90 dpf) exhibit more cognitive tasks, modality‐dominant earlier (TeO) development (TS, OB). Complete optical access ’s lifespan provides unique opportunity how structure over correlates with connectivity, microcircuitry, behavior.

Language: Английский

Citations

0
Neural Circuit Transitions Supporting Developmentally Specific Social Behavior DOI Creative Commons
Nicole C. Ferrara, Alicia Che, Brandy A. Briones

et al.

Journal of Neuroscience, Journal Year: 2023, Volume and Issue: 43(45), P. 7456 - 7462

Published: Nov. 8, 2023

Environmentally appropriate social behavior is critical for survival across the lifespan. To support this flexible behavior, brain must rapidly perform numerous computations taking into account sensation, memory, motor-control, and many other systems. Further complicating process, individuals distinct behaviors adapted to unique demands of each developmental stage; indeed, newborn would not be in adulthood vice versa. However, our understanding neural circuit transitions supporting these behavioral has been limited. Recent advances dissection tools, as well adaptation tools use at early time points, helped uncover several novel mechanisms developmentally behavior. This review, associated Minisymposium, bring together neuroscience research model organisms ages. Together, work highlights regulated functional roles sensory cortex, prefrontal amygdala, habenula, thalamus interaction from infancy adulthood. These studies underscore need synthesis varied ages advance

Language: Английский

Citations

8
Particle size-dependent effects of silver nanoparticles on swim bladder damage in zebrafish larvae DOI Creative Commons

Yongfei Gao,

Pengyuan Yang,

Jingxue Zhu

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2022, Volume and Issue: 249, P. 114363 - 114363

Published: Dec. 9, 2022

Particle size-dependent biological effects of silver nanoparticles (AgNPs) are great interest; however, the mechanism action ions (Ag+) released from AgNPs concerning AgNP particle size remains unclear. Thus, we evaluated influence (20, 40, 60, and 80 nm) on acute 96-h bioaccumulation toxicity (swim bladder damage) in zebrafish (Danio rerio) larvae, with a focus Ag+ differently sized AgNPs. The 40- 60-nm were more toxic than 20- 80-nm versions terms inflammation oxidative damage to swim bladder, as indicated by inhibition type 2 iodothyroxine deiodinase enzyme activity, mitochondrial injury, reduced 30-50% adenosine triphosphate content. Furthermore, up-regulation down-regulation development-related gene expression was not observed for pbx1a anxa5, but shha ihha no statistical significance. That 20-nm less attributed their rapid elimination larvae comparison 40-, 60-, AgNPs; thus, AgNP-exposed larvae. Failed inflation bladders affected rather themselves. Overall, reveal contribution underlying provide scientific basis comprehensively assessing ecological risk biosafety

Language: Английский

Citations

11
A brainstem circuit for gravity-guided vertical navigation DOI Creative Commons
Yunlu Zhu, Hannah Gelnaw, Franziska Auer

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: March 13, 2024

ABSTRACT The sensation of gravity anchors our perception the environment and is crucial for navigation. However, neural circuits that transform into commands navigation are undefined. We first determined larval zebrafish ( Danio rerio ) navigate vertically by maintaining a consistent heading across series upward climb or downward dive bouts. Gravity-blind mutant fish swim with more variable excessive veering, leading to inefficient vertical After targeted photoablation ascending vestibular neurons spinal projecting midbrain neurons, but not vestibulospinal was impaired. These data define sensorimotor circuit uses evolutionarily-conserved brainstem architecture gravitational signals persistent work lays foundation understand how inputs allow animals move efficiently through their environment.

Language: Английский

Citations

2