The role of subicular VIP-expressing interneurons on seizure dynamics in the intrahippocampal kainic acid model of temporal lobe epilepsy

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: May 30, 2023

Abstract The subiculum, a key output region of the hippocampus, is increasingly recognized as playing crucial role in seizure initiation and spread. subiculum consists glutamatergic pyramidal cells, which show alterations intrinsic excitability course epilepsy, multiple types GABAergic interneurons, exhibit varying characteristics epilepsy. In this study, we aimed to assess vasoactive intestinal peptide interneurons (VIP-INs) ventral pathophysiology temporal lobe We observed that an anatomically restricted inhibition VIP-INs was sufficient reduce seizures intrahippocampal kainic acid model changing circadian rhythm seizures, emphasizing critical small cell population modulating TLE. As expected, permanent unilateral or bilateral silencing non-epileptic animals did not induce epileptiform activity. Interestingly, transient activation enough increase frequency acute model. Our results offer new perspectives on involvement Given predominant disinhibitory input subicular microcircuits, modifications could be considered development therapeutic strategies improve control.

Language: Английский

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CaMKIIα neurons in the anterior insular cortex regulate attention behavior in mice

Frontiers in Neural Circuits, Journal Year: 2023, Volume and Issue: 17

Published: July 4, 2023

Introduction The insular cortex is involved in multiple physiological processes including working memory, pain, emotion, and interoceptive functions. Previous studies have indicated that the anterior (aIC) also mediates attention humans. However, exact cellular function of aIC regulation this process still elusive. Methods In study, using 5-choice serial reaction time task (5-CSRTT) testing paradigm, we assessed role visuospatial impulsiveness mice. Results results showed a dramatic activation c-Fos CaMKIIα neurons after 5-CSRTT procedure. vivo fiber photometry revealed enhanced calcium signaling when mice responded correctly. addition, chemogenetic suppression led to increased incorrect responses within appropriate time. Importantly, pharmacological their performance test. Discussion These provide compelling evidence are essential for modulation attentional processing

Language: Английский

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Abnormalities of structural covariance of insular subregions in drug-naïve OCD patients

Cerebral Cortex, Journal Year: 2023, Volume and Issue: 34(1)

Published: Dec. 15, 2023

Abstract The insula plays a significant role in the neural mechanisms of obsessive-compulsive disorder. Previous studies have identified functional and structural abnormalities disorder patients. predictive coding model context interoception can explain psychological neuropathological manifestations observed is based on degree laminar differentiation cerebral cortex. interindividual differences local measure brain structure often covary with other regions. We investigated anatomical network involving drug-naïve sample. recruited 58 patients 84 matched health controls. cortical thickness covariance maps between groups were compared at each vertex. also evaluated modulation Yale–Brown Obsessive-Compulsive Scale scores duration covariance. Our findings indicated that seeded from granular dysgranular are different severity modulate posterior cingulate cortex rostral anterior results revealed aberrant insular characteristics patients, contributing to better understanding involvement pathological underlying

Language: Английский

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