Autism Spectrum Disorders: Advances in Proteomics DOI

Hui Zhou,

Xiao-Li Feng

Protein and Peptide Letters, Journal Year: 2023, Volume and Issue: 30(5), P. 384 - 395

Published: April 14, 2023

Autism is a class of developmental disorders with extremely high rates disability, affecting patients throughout their lives. There no cure to date clinically, and early rehabilitation interventions can improve some the behavioral problems autistic patients, but these are limited by age often have minimal effects in older adults autism. Early diagnosis also necessary while developing effective autism therapies. At present, dependent on search for markers an attempt screen differentially expressed proteins using high-throughput assays, such as synaptic scaffolding proteins, microtubule-associated apolipoproteins, immunoglobulin G complement factor-related etc. It would be big step forward mechanistic studies if valid biomarker could found.

Language: Английский

Brain circuits that regulate social behavior DOI Creative Commons
Hao Li, Zhe Zhao,

Shaofei Jiang

et al.

Molecular Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: April 26, 2025

Social interactions are essential for the survival of individuals and reproduction populations. stressors, such as social defeat isolation, can lead to emotional disorders cognitive impairments. Furthermore, dysfunctional behaviors hallmark symptoms various neuropsychiatric disorders, including autism spectrum disorder (ASD) post-traumatic stress (PTSD). Consequently, understanding neural circuit mechanisms underlying has become a major focus in neuroscience. behaviors, which encompass wide range expressions phases, regulated by complex networks. In this review, we summarize recent progress identifying circuits involved different types general investigation, preference, mating, aggression, parenting, prosocial dominance behaviors. We also outline associated with deficits ASD, schizophrenia, PTSD. Given pivotal role rodents behavior research, our review primarily focuses on these animals. Finally, propose future research directions, development specific behavioral paradigms, identification motor output, integration activity, transcriptome, connectome data, multifunctional roles neurons multiple targets, among brain regions.

Language: Английский

Citations

0
BLA-involved circuits in neuropsychiatric disorders DOI

Lin‐Hui Ma,

Shuai Li,

Xin‐Hao Jiao

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 99, P. 102363 - 102363

Published: June 4, 2024

Language: Английский

Citations

3
The PFC-LH-VTA pathway contributes to social deficits in IRSp53-mutant mice DOI Creative Commons
Young Woo Noh, Yangsik Kim, Soowon Lee

et al.

Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 28(11), P. 4642 - 4654

Published: Sept. 20, 2023

Abstract Dopamine (DA) neurons in the ventral tegmental area (VTA) promote social brain functions by releasing DA onto nucleus accumbens neurons, but it remains unclear how VTA communicate with cortical neurons. Here, we report that medial prefrontal cortex (mPFC)-lateral hypothalamus (LH)-VTA pathway contributes to deficits mice IRSp53 deletion restricted excitatory ( Emx1-Cre;Irsp53 fl/fl mice). LH-projecting mutant mPFC display abnormally increased excitability involving decreased potassium channel gene expression, leading excessive synaptic input LH-GABA A circuit-specific also increases neuronal and induces deficits. show a compensatory decrease excitability, weakening inhibitory LH GABA -VTA subsequently over-activating VTA-GABA over-inhibiting VTA-DA Accordingly, optogenetic activation of improves mice. Therefore, mPFC-LH

Language: Английский

Citations

7
YBX1‐Mediated DNA Methylation‐Dependent SHANK3 Expression in PBMCs and Developing Cortical Interneurons in Schizophrenia DOI Creative Commons
Peiyan Ni, Chuqing Zhou, Sugai Liang

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(20)

Published: May 21, 2023

Abstract Schizophrenia (SCZ) is a severe psychiatric and neurodevelopmental disorder. The pathological process of SCZ starts early during development, way before the first onset psychotic symptoms. DNA methylation plays an important role in regulating gene expression dysregulated involved pathogenesis various diseases. methylated immunoprecipitation‐chip (MeDIP‐chip) performed to investigate genome‐wide dysregulation peripheral blood mononuclear cells (PBMCs) patients with first‐episode (FES). Results show that SHANK3 promoter hypermethylated, this hypermethylation (HyperM) negatively correlated cortical surface area left inferior temporal cortex positively negative symptom subscores FES. transcription factor YBX1 further found bind HyperM region induced pluripotent stem (iPSCs)‐derived interneurons (cINs) but not glutamatergic neurons. Furthermore, direct positive regulatory effect on confirmed cINs using shRNAs. In summary, suggests potential neuropathological mechanism underlying SCZ. results also suggest PBMCs can serve as biomarker

Language: Английский

Citations

6
Restoration of nNOS Expression Rescues Autistic-Like Phenotypes Through Normalization of AMPA Receptor-Mediated Neurotransmission DOI

Xiaona Wang,

Yaodong Zhang, Shuying Luo

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 61(9), P. 6599 - 6612

Published: Feb. 8, 2024

Language: Английский

Citations

2
Targeting epigenetic dysregulation in autism spectrum disorders DOI

Macarena L Herrera,

Juan Paraíso‐Luna,

Isabel Bustos-Martínez

et al.

Trends in Molecular Medicine, Journal Year: 2024, Volume and Issue: 30(11), P. 1028 - 1046

Published: July 5, 2024

Language: Английский

Citations

2
Identification of Young High-Functioning Autism Individuals Based on Functional Connectome Using Graph Isomorphism Network: A Pilot Study DOI Creative Commons

Si-Hong Yang,

De-Zhi Jin,

Jun Liu

et al.

Brain Sciences, Journal Year: 2022, Volume and Issue: 12(7), P. 883 - 883

Published: July 5, 2022

Accumulated studies have determined the changes in functional connectivity autism spectrum disorder (ASD) and spurred application of machine learning for classifying ASD. Graph Neural Network provides a new method network analysis brain disorders to identify underlying features associated with deficits. Here, we proposed an improved model Isomorphism (GIN) that implements Weisfeiler-Lehman (WL) graph isomorphism test learn while taking into account importance each node classification improve interpretability algorithm. We applied on multisite datasets resting-state connectome from Autism Brain Imaging Data Exchange (ABIDE) after stringent quality control. The outperformed other commonly used methods five different evaluation metrics. also identified salient ROIs visual frontoparietal control networks, which could provide potential neuroimaging biomarkers ASD identification.

Language: Английский

Citations

9
Persistent hypersomnia following repetitive mild experimental traumatic brain injury: Roles of chronic stress and sex differences DOI Creative Commons

Edwin Portillo,

Xiaomei Zi,

Yeonho Kim

et al.

Journal of Neuroscience Research, Journal Year: 2023, Volume and Issue: 101(6), P. 843 - 865

Published: Jan. 9, 2023

Abstract Traumatic brain injury (TBI) is often more complicated than a single head injury. An extreme example of this point may be military service members who experience spectrum exposures over prolonged period under stressful conditions. Understanding the effects complex can inform evaluation and care to prevent persistent symptoms. We designed longitudinal series non‐invasive procedures in adult mice evaluate mild stress exposures. assessed anxiety, depression, sleep–wake dysfunction as symptoms that impact long‐term outcomes after TBI. Unpredictable chronic (UCMS) was generated from varied sequence environmental stressors distributed within each 21 days. Subsequently, received blast combined with closed‐head TBI on 5 days at 24‐h intervals. In males females, UCMS induced anxiety without depressive behavior. A major finding reproducible through 6‐ 12‐month time points male repetitive plus events, or surprisingly just alone. Specifically, exhibited hypersomnia increased sleep during active/dark phase fragmentation longer wake bouts. Sleep–wake not found events alone, females any These results identify sex differences important considerations for dysfunction. Furthermore, impaired wakefulness similar excessive daytime sleepiness reported patients, including patients TBI, which warrants further clinical screening, care, treatment development.

Language: Английский

Citations

5
Maturation of a cortical-amygdala circuit limits sociability in male rats DOI
Nicole C. Ferrara, Sydney Trask,

Mallika Padival

et al.

Cerebral Cortex, Journal Year: 2023, Volume and Issue: 33(13), P. 8391 - 8404

Published: April 6, 2023

Abstract Prefrontal cortical maturation coincides with adolescent transitions in social engagement, suggesting that it influences development. The anterior cingulate cortex (ACC) is important for interaction, including ACC outputs to the basolateral amygdala (BLA). However, little known about ACC-BLA sensitivity environment and if this changes during maturation. Here, we used brief (2-hour) isolation test immediate impact of changing on circuit subsequent shifts behavior adult rats. We found optogenetic inhibition reduced isolation-driven facilitation interaction across ages. Isolation increased activity neurons ages, but altered influence BLA an age-dependent manner. inhibitory stimulation a frequency-dependent manner adults, uniformly suppressed ACC-driven adolescents. This work identifies alterations circuit, itself as essential region sensitive regulates its both adults

Language: Английский

Citations

5
High definition transcranial direct current stimulation of the Cz improves social dysfunction in children with autism spectrum disorder: A randomized, sham, controlled study DOI
Y. Wang, Fei Wang, Yue Kong

et al.

Autism Research, Journal Year: 2023, Volume and Issue: 16(10), P. 2035 - 2048

Published: Sept. 11, 2023

Abstract The purpose of this study was to determine the effect Cz high‐definition 5‐channel tDCS (HD‐tDCS) on social function in 4–12 years‐old children with autism spectrum disorder (ASD). This a randomized, double‐blind, pseudo‐controlled trial which 45 ASD were recruited and divided into three groups sex, age, rehabilitation treatment as control variables. Each group 15 randomly administered active HD‐tDCS central anode, left dorsolateral prefrontal cortex (F3) sham anode 14 daily sessions 3 weeks. Social Responsiveness Scale Chinese Version (SRS‐Chinese Version) compared 1 week after stimulation values recorded prior stimulation. At end treatment, both anodal DLFPC decreased measures SRS‐Chinese Version. total score by 13.08%, cognition 18.33%, communication 10.79%, significantly improved over group, especially young middle low function. There no significant change subscale group. In F3 13%, autistic behavior 19.39%, 14.39%, all improved. However, there difference between DLPFC conditions. may be an effective for dysfunction ASD.

Language: Английский

Citations

5