Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(5), P. 574 - 574
Published: May 7, 2024
Proteins
are
essential
molecules
that
play
crucial
roles
in
maintaining
cellular
homeostasis
and
carrying
out
biological
functions
such
as
catalyzing
biochemical
reactions,
structural
proteins,
immune
response,
etc.
However,
proteins
also
highly
susceptible
to
damage
by
reactive
oxygen
species
(ROS)
nitrogen
(RNS).
In
this
review,
we
summarize
the
role
of
protein
oxidation
normal
aging
Alzheimer's
disease
(AD).
The
major
emphasis
review
article
is
on
carbonylation
nitration
AD
mild
cognitive
impairment
(MCI).
oxidatively
modified
showed
a
strong
correlation
with
reported
changes
brain
structure,
carbohydrate
metabolism,
synaptic
transmission,
energetics,
etc.,
both
MCI
brains
compared
controls.
Some
were
found
be
common
targets
observed
during
early
stages
AD,
suggesting
those
might
critical
onset
symptoms
and/or
formation
pathological
hallmarks
AD.
Further
studies
required
fully
elucidate
progression
pathogenesis
IBRO Neuroscience Reports,
Journal Year:
2022,
Volume and Issue:
14, P. 64 - 76
Published: Nov. 18, 2022
Alzheimer's
disease
(AD)
is
the
most
common
cause
of
dementia
worldwide.
Because
has
no
known
treatment,
sufferers
and
their
caregivers
must
concentrate
on
symptom
management.
Astrocytes
microglia
are
now
to
play
distinct
physiological
roles
in
synaptic
function,
blood-brain
barrier,
neurovascular
coupling.
Consequently,
search
for
drugs
that
can
slow
degenerative
process
continues
because
existing
designed
alleviate
symptoms
disease.
Drugs
address
pathological
changes
without
interfering
with
normal
function
glia,
such
as
eliminating
amyloid-beta
deposits,
prospective
treatments
neuroinflammatory
illnesses.
neuron-astrocytes-microglia
interactions
so
complex,
developing
effective,
preventive,
therapeutic
medications
AD
will
necessitate
novel
methodologies
strategic
targets.
This
review
focused
used
treating
amongst
which
include
Donepezil,
Choline
Alphoscerate,
Galantamine,
Dextromethorphan,
palmitoylethanolamide,
citalopram,
resveratrol,
solanezumab.
summarizes
effects
these
neurons,
astrocytes,
based
pharmacokinetic
properties,
mechanism
action,
dosing,
clinical
presentations.
Aging and Disease,
Journal Year:
2023,
Volume and Issue:
15(2), P. 459 - 459
Published: Aug. 2, 2023
Alzheimer's
disease
(AD)
is
a
devastating
neurodegenerative
disorder
that
impacts
substantial
number
of
individuals
globally.
Despite
its
widespread
prevalence,
there
currently
no
cure
for
AD.
It
widely
acknowledged
normal
synaptic
function
holds
key
role
in
memory,
cognitive
abilities,
and
the
interneuronal
transfer
information.
As
AD
advances,
symptoms
including
impairment,
decreased
density,
decline
become
increasingly
noticeable.
The
importance
glial
cells
formation
synapses,
growth
neurons,
brain
maturation,
safeguarding
microenvironment
central
nervous
system
well
recognized.
However,
during
progression,
overactive
can
cause
dysfunction,
neuronal
death,
abnormal
neuroinflammation.
Both
neuroinflammation
dysfunction
are
present
early
stages
Therefore,
focusing
on
changes
glia-synapse
communication
could
provide
insights
into
mechanisms
behind
In
this
review,
we
aim
to
summary
various
cells,
microglia,
astrocytes,
oligodendrocytes,
oligodendrocyte
precursor
regulating
dysfunction.
This
may
offer
new
perspective
investigating
underlying
Molecular Psychiatry,
Journal Year:
2023,
Volume and Issue:
28(10), P. 4407 - 4420
Published: March 23, 2023
The
study
of
Alzheimer's
Disease
(AD)
has
traditionally
focused
on
neuropathological
mechanisms
that
guided
therapies
attenuate
features.
A
new
direction
is
emerging
in
AD
research
focuses
the
progressive
loss
cognitive
function
due
to
disrupted
neural
circuit
mechanisms.
Evidence
from
humans
and
animal
models
show
dysregulated
circuits
initiate
a
cascade
pathological
events
culminate
functional
learning,
memory,
other
aspects
cognition.
Recent
progress
single-cell,
spatial,
omics
informs
this
circuit-focused
approach
by
determining
identities,
locations,
circuitry
specific
cells
affected
AD.
Recently
developed
neuroscience
tools
allow
for
precise
access
cell
type-specific
so
their
roles
AD-related
deficits
disease
progression
can
be
tested.
An
integrated
systems-level
understanding
AD-associated
requires
multimodal
multi-scale
interrogations
longitudinally
measure
and/or
manipulate
ensemble
properties
molecularly-defined
neuron
populations
first
susceptible
These
newly
technological
conceptual
advances
present
opportunities
studying
treating
vulnerable
represent
beginning
era
circuit-based
research.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(5), P. 574 - 574
Published: May 7, 2024
Proteins
are
essential
molecules
that
play
crucial
roles
in
maintaining
cellular
homeostasis
and
carrying
out
biological
functions
such
as
catalyzing
biochemical
reactions,
structural
proteins,
immune
response,
etc.
However,
proteins
also
highly
susceptible
to
damage
by
reactive
oxygen
species
(ROS)
nitrogen
(RNS).
In
this
review,
we
summarize
the
role
of
protein
oxidation
normal
aging
Alzheimer's
disease
(AD).
The
major
emphasis
review
article
is
on
carbonylation
nitration
AD
mild
cognitive
impairment
(MCI).
oxidatively
modified
showed
a
strong
correlation
with
reported
changes
brain
structure,
carbohydrate
metabolism,
synaptic
transmission,
energetics,
etc.,
both
MCI
brains
compared
controls.
Some
were
found
be
common
targets
observed
during
early
stages
AD,
suggesting
those
might
critical
onset
symptoms
and/or
formation
pathological
hallmarks
AD.
Further
studies
required
fully
elucidate
progression
pathogenesis
