Roles of TRIM21/Ro52 in connective tissue disease-associated interstitial lung diseases

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 6, 2024

Multiple factors contribute to the development of connective tissue diseases (CTD), often alongside a range interstitial lung (ILD), including Sjögren's syndrome-associated ILD, systemic sclerosis-associated lupus erythematosus-associated idiopathic inflammatory myositis-associated ILD. TRIM21(or Ro52), an E3 ubiquitin ligase, plays vital role in managing innate and adaptive immunity, maintaining cellular homeostasis, is focal target for autoantibodies various rheumatic autoimmune diseases. However, effectiveness anti-TRIM21 antibodies diagnosing CTD remains matter debate because their non-specific nature. Recent studies indicate that TRIM21 its autoantibody are involved pathogenesis CTD-ILD play important diagnosis prognosis. In this review, we focus on contribution CTD-ILD, as well potential diagnostic value different types disease progression novel therapeutic target.

Language: Английский

[TRIM21 Inhibits the Proliferation and Migration of Lung Adenocarcinoma Cells 
by Interacting with ZSWIM1].

PubMed, Journal Year: 2024, Volume and Issue: 27(5), P. 337 - 344

Published: May 20, 2024

Lung adenocarcinoma (LUAD) is a highly morbid and fatal cancer. Despite advancements in modern medical treatment, the 5-year survival rate of patients remains suboptimal. Our previous study revealed that zinc finger SWIM-type containing 1 (ZSWIM1), novel protein, promotes proliferation, migration, invasion LUAD cells. The aim this to investigate impact E3 ubiquitin ligase tripartite motif protein 21 (TRIM21) on ZSWIM1-mediated cell proliferation migration.

Language: Английский

Inhibition of the neddylation E2 enzyme UBE2M in macrophages protects against E. coli-induced sepsis

Journal of Biological Chemistry, Journal Year: 2024, Volume and Issue: 301(1), P. 108085 - 108085

Published: Dec. 13, 2024

Language: Английский