Dynamic representation of appetitive and aversive stimuli in nucleus accumbens shell D1- and D2-medium spiny neurons

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 2, 2025

The nucleus accumbens (NAc) is a key brain region for motivated behaviors, yet how distinct neuronal populations encode appetitive or aversive stimuli remains undetermined. Using microendoscopic calcium imaging in mice, we tracked NAc shell D1- D2-medium spiny neurons' (MSNs) activity during exposure to of opposing valence and associative learning. Despite drift individual coding, both D2-population was sufficient discriminate unconditioned stimuli, but not predictive cues. Notably, D2-MSNs were similarly co-recruited conditioning, supporting concurrent role Conversely, when contingencies changed, there an asymmetric response the NAc, with more pronounced changes D2-MSNs. Optogenetic manipulation provided causal evidence necessity this population extinction associations. Our results reveal neurons valence, Pavlovian associations their extinction, unveil mechanisms underlying behaviors. rewarding Here, authors show that appeared be relevant

Language: Английский

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Astrocyte ensembles manipulated with AstroLight tune cue-motivated behavior

Nature Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Language: Английский

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D1 and D2 medium spiny neurons in the nucleus accumbens core have distinct and valence-independent roles in learning

Neuron, Journal Year: 2023, Volume and Issue: 112(5), P. 835 - 849.e7

Published: Dec. 21, 2023

Language: Английский

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Dissociable encoding of motivated behavior by parallel thalamo-striatal projections

Current Biology, Journal Year: 2024, Volume and Issue: 34(7), P. 1549 - 1560.e3

Published: March 7, 2024

The successful pursuit of goals requires the coordinated execution and termination actions that lead to positive outcomes. This process relies on motivational states are guided by internal drivers, such as hunger or fear. However, mechanisms which brain tracks shape instrumental not fully understood. paraventricular nucleus thalamus (PVT) is a midline thalamic shapes motivated behaviors via its projections accumbens (NAc)

Language: Английский

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Nucleus accumbens neurons dynamically respond to appetitive and aversive associative learning

Journal of Neurochemistry, Journal Year: 2024, Volume and Issue: 168(3), P. 312 - 327

Published: Feb. 5, 2024

Abstract To survive, individuals must learn to associate cues in the environment with emotionally relevant outcomes. This association is partially mediated by nucleus accumbens (NAc), a key brain region of reward circuit that mainly composed GABAergic medium spiny neurons (MSNs), express either dopamine receptor D1 or D2. Recent studies showed both populations can drive and aversion, however, activity these during appetitive aversive Pavlovian conditioning remains be determined. Here, we investigated relevance D1‐ D2‐neurons associative learning, measuring calcium transients fiber photometry tasks mice. Sucrose was used as positive valence unconditioned stimulus (US) foot shock negative US. We show conditioning, exhibit general increase response conditioned stimuli (CS). Interestingly, present distinct changes after sucrose consumption dynamically evolve throughout learning. During an CS US (shock). Our data support model which are concurrently activated conditioning. image

Language: Английский

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The nucleus accumbens in reward and aversion processing: insights and implications

Frontiers in Behavioral Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Aug. 9, 2024

The nucleus accumbens (NAc), a central component of the brain's reward circuitry, has been implicated in wide range behaviors and emotional states. Emerging evidence, primarily drawing from recent rodent studies, suggests that function NAc aversion processing is multifaceted. Prolonged stress or drug use induces maladaptive neuronal which results pathological conditions. This review aims to provide comprehensive up-to-date insights on role motivated behavior regulation highlights areas demand further in-depth analysis. It synthesizes latest findings how distinct populations pathways contribute opposite valences. examines neuromodulators, especially monoamines, influence NAc's control over various motivational Furthermore, it delves into complex underlying mechanisms psychiatric disorders such as addiction depression evaluates prospective interventions restore functionality.

Language: Английский

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The nucleus accumbens shell: a neural hub at the interface of homeostatic and hedonic feeding

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: July 30, 2024

Feeding behavior is a complex physiological process regulated by the interplay between homeostatic and hedonic feeding circuits. Among neural structures involved, nucleus accumbens (NAc) has emerged as pivotal region at interface of these two The NAc comprises distinct subregions in this review, we focus mainly on shell (NAcSh). Homeostatic circuits, primarily found hypothalamus, ensure organism's balance energy nutrient requirements. These circuits monitor peripheral signals, such insulin, leptin, ghrelin, modulate satiety hunger states. NAcSh receives input from integrating information regarding metabolic needs. Conversely, so-called involve all other non-hunger -satiety processes, i.e., sensory information, associative learning, reward, motivation pleasure associated with food consumption. interconnected hedonics-related like ventral tegmental area prefrontal cortex plays key role encoding related to palatable seeking or In sum, acts crucial hub behavior, signals both facilitate behavioral output via its downstream projections. Moreover, NAcSh's involvement extends beyond simple integration, it directly impacts actions first delineating inputs targeting NAcSh; then present projections structures. Finally discuss how regulates can be seen functionally diverse set projection neuron subpopulations.

Language: Английский

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Distinct circuits and molecular targets of the paraventricular hypothalamus decode visceral and somatic pain

Neuron, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

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NMDA-induced lesions of the nucleus accumbens core increase the innately rewarding saccharin solution intake and methamphetamine-induced conditioned place preference but not conditioned taste aversion in rats

Pharmacology Biochemistry and Behavior, Journal Year: 2025, Volume and Issue: 248, P. 173957 - 173957

Published: Jan. 13, 2025

Language: Английский

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Nucleus accumbens D2-expressing neurons: Balancing reward and licking disruption through rhythmic optogenetic stimulation

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(2), P. e0317605 - e0317605

Published: Feb. 7, 2025

Nucleus accumbens (NAc) dopamine D1 receptor-expressing neurons are known to be critical for processing reward and regulating food intake. However, the role of D2-expressing in this nucleus remains less understood. This study employed optogenetic manipulations investigate NAc sucrose consumption. Optogenetic activation these decreased preference (at 20 Hz), disrupted licking patterns (particularly at 8 increased self-stimulation. Conversely, synchronizing stimulation with animal rhythm mitigated disruption even intake, suggesting a rewarding effect. Furthermore, Hz (but not Hz) induced place real-time (RTPP) test. In contrast, inhibiting D2 produced negative hedonic state, although reaching complete aversion, influencing choices specific contexts. For instance, while RTPP test per se was sensitive enough observe aversion when mice could choose between consuming high-fat diet (HFD) pellet context associated or without inhibition neurons, they preferred consume HFD on non-inhibited side. suggests that palatability can unmask also overshadow) state neuron inhibition. A reinforcement paradigm further confirmed active avoidance behavior by conclusion, induces has dual effect-it is yet disrupts behavior-highlighting its complex consummatory behavior. Importantly, self-paced stimulation, where controls timing through behavior, offers more efficient natural approach stimulating activity.

Language: Английский

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